Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Investigation of DNA double-strand break repair mechanisms in microsatellite regions using the CRISPR/Cas system

2018/29/B/NZ1/00293

Keywords:

genome editing DNA repair Huntington's disease

Descriptors:

  • NZ2_1: Molecular genetics
  • NZ1_5: Genetic engineering
  • NZ1_1: Molecular biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marta Olejniczak 

Number of co-investigators in the project: 5

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 533 600 PLN

Project start date (Y-m-d): 2019-01-14

Project end date (Y-m-d): 2023-01-13

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. zestaw komputerowy z drukarką.
  2. Zestaw komputerowy wraz z oprogramowaniem (2 szt.) (15 000 PLN)
  3. dewar do przechowywania komórek w ciekłym azocie (10 000 PLN)
  4. inkubator (40 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Advances in Modeling Polyglutamine Diseases Using Genome Editing Tools
    Authors:
    Karwacka M, Olejniczak M.
    Academic press:
    Cells (rok: 2022, tom: 11 ,517, strony: 45317), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11030517 - link to the publication
  2. Universal RNAi Triggers for the Specific Inhibition of Mutant Huntingtin, Atrophin-1, Ataxin-3, and Ataxin-7 Expression
    Authors:
    Kotowska-Zimmer A, Ostrovska Y, Olejniczak M
    Academic press:
    Mol Ther Nucleic Acids (rok: 2020, tom: 19, strony: 562-571), Wydawca: CellPress
    Status:
    Published
    DOI:
    10.1016/j.omtn.2019.12.012 - link to the publication
  3. Generation of New Isogenic Models of Huntington's Disease Using CRISPR-Cas9 Technology
    Authors:
    Dabrowska M, Ciolak A, Kozlowska E, Fiszer A, Olejniczak M.
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 1854), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21051854 - link to the publication
  4. Computational Tools and Resources Supporting CRISPR-Cas Experiments
    Authors:
    Sledzinski P, Nowaczyk M, Olejniczak M.
    Academic press:
    Cells (rok: 2020, tom: 9, strony: 1288), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9051288 - link to the publication
  5. Paving the way towards precise and safe CRISPR genome editing
    Authors:
    P. Sledzinski, M. Dabrowska, M. Nowaczyk, M. Olejniczak
    Academic press:
    BIOTECHNOLOGY ADVANCES (rok: 2021, tom: 49, strony: Nie dotyczy), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.biotechadv.2021.107737 - link to the publication

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