Thermodynamic parameters and rules towards the determination of RNA folding in in vivo-like conditions. RNA folding predictions for a better understanding of their structure and function in mammalian cells.
2019/33/B/ST4/01422
Keywords
Descriptors
- ST4_001: Chemia fizyczna, fizyka chemiczna
- ST4_009: Chemia biologiczna
- ST4_003: Struktura i architektura molekularna
Panel
ST4 – Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development
Host institution
Instytut Chemii Bioorganicznej PAN
Voivodeship: wielkopolskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 4
Call
OPUS 17 – announced on 2019-03-15
- Amount awarded
- 1 812 200 PLN
- Project start date
- 2020-02-25
- Project end date
- 2025-02-24
- Project duration
- 60 months (the same as in the proposal)
- Project status
- Project completed
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (13)
-
Universal and strain specific structure features of segment 8 genomic RNA of influenza A virus - application of 4-thiouridine photocrosslinking
- Authors:
- M. Soszynska-Jozwiak, M. Pszczola, J. Piasecka, J.M. Peterson, W.N. Moss, K. Taras-Goslinska, R. Kierzek, E. Kierzek
- Academic press:
- Journal of Biological Chemistry (year: 2021, volume: 297, pages: 101245), Publisher: ASBMB
- Status:
- Published
- DOI:
- 10.1016/j.jbc.2021.101245 – link to the publication
-
Secondary Structure of Subgenomic RNA M of SARS-CoV-2
- Authors:
- M. Soszynska-Jozwiak, A. Ruszkowska, R. Kierzek, C.A. O'Leary, W.N. Moss and E. Kierzek
- Academic press:
- VIRUSES-BASEL (year: 2022, volume: 14, pages: 322), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/v14020322 – link to the publication
-
Secondary Structure of Influenza A Virus Genomic Segment 8 RNA Folded in A Cellular Environment
- Authors:
- B. Szutkowska, K. Wieczorek, R. Kierzek, P. Zmora, J.M. Peterson, W.N. Moss, D.H. Mathews and E. Kierzek
- Academic press:
- International Journal of Molecular Sciences (year: 2022, volume: 23, pages: 2452), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms23052452 – link to the publication
-
A Structural Potential of Rare Trinucleotide Repeat Tracts in RNA
- Authors:
- D. Magner, R. Nowak, E. Lenartowicz Onyekaa, A. Pasternak, R. Kierzek
- Academic press:
- International Journal of Molecular Sciences (year: 2022, volume: 23, pages: 5850), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms23105850 – link to the publication
-
METTL16, Methyltransferase-like Protein 16: Current Insights into Structure and Function
- Authors:
- Ruszkowska A.
- Academic press:
- International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 2176), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms22042176 – link to the publication
-
Conserved Structural Motifs of Two Distant IAV Subtypes in Genomic Segment 5 RNA
- Authors:
- P. Michalak, J. Piasecka, B. Szutkowska, R. Kierzek, E. Biala, W.N. Moss and E. Kierzek
- Academic press:
- VIRUSES-BASEL (year: 2021, volume: 13, pages: 525), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/v13030525 – link to the publication
-
Secondary Structure Prediction for RNA Sequences Including N6-methyladenosine.
- Authors:
- E. Kierzek, X. Zhang, R. Watson, S. Kennedy, M. Szabat, R. Kierzek, and D. Mathews
- Academic press:
- Nature Communications (year: 2022, volume: 13, pages: 1271), Publisher: NATURE PORTFOLIOHEIDELBERGER PLATZ 3, BERLIN 14197, GERMANY
- Status:
- Published
- DOI:
- 10.1038/s41467-022-28817-4 – link to the publication
-
A Test and Refinement of Folding Free Energy Nearest Neighbor Parameters for RNA Including N6-Methyladenosine.
- Authors:
- M. Szabat, M. Prochota, R. Kierzek, E. Kierzek, D. H. Mathews
- Academic press:
- Journal of Molecular Biology (year: 2022, volume: 434, pages: 167632), Publisher: CADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
- Status:
- Published
- DOI:
- 10.1016/j.jmb.2022.167632 – link to the publication
-
Structural variants and modifications of hammerhead ribozymes targeting influenza A virus conserved structural motifs.
- Authors:
- T. Czapik, J. Piasecka, R. Kierzek, E. Kierzek
- Academic press:
- Molecular Therapy – Nucleic Acids (year: 2022, volume: 29, pages: 64-74), Publisher: CELL PRESS 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139
- Status:
- Published
- DOI:
- 10.1016/j.omtn.2022.05.035 – link to the publication
-
Secondary Structure of Influenza A Virus Genomic Segment 8 RNA Folded in A Cellular Environment.
- Authors:
- B. Szutkowska, K. Wieczorek, R. Kierzek, P. Zmora, J.M. Peterson, W.N. Moss, D.H. Mathews and E. Kierzek
- Academic press:
- International Journal of Molecular Sciences (year: 2022, volume: 23, pages: 2452), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms23052452 – link to the publication
-
RNA Secondary Structure as a First Step for Rational Design of the Oligonucleotides towards Inhibition of Influenza A Virus Replication
- Authors:
- M. Szabat, D. Lorent, T. Czapik, M. Tomaszewska, E. Kierzek, R. Kierzek
- Academic press:
- Pathohens (year: 2020, volume: 9, pages: 925), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/pathogens9110925 – link to the publication
-
Secondary Structure of Subgenomic RNA M of SARS-CoV-2
- Authors:
- M. Soszynska-Jozwiak, A. Ruszkowska, R. Kierzek, C.A. O'Leary, W.N. Moss and E. Kierzek
- Academic press:
- Viruses-Basel (year: 2022, volume: 14, pages: 322), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/v14020322 – link to the publication
-
Secondary Structure Prediction for RNA Sequences Including N6-methyladenosine
- Authors:
- E. Kierzek, X. Zhang, R. Watson, S. Kennedy, M. Szabat, R. Kierzek, and D. Mathews
- Status:
- Accepted for publication