Projects funded by the NCN

Identifying early biomarkers and molecular targets for therapeutic intervention in right ventricular dysfunction

Call: OPUS 28 , Panel: NZ5

Principal investigator: prof. Przemysław Błyszczuk

Uniwersytet Jagielloński

Tick-borne encephalitis virus protease as a molecular target for novel inhibitors and activity-based probes

Call: OPUS 28 , Panel: NZ6

Principal investigator: dr Renata Grzywa

Politechnika Wrocławska

The H3K27M oncohistone-centred molecular mechanisms as therapeutic targets in pediatric malignant diffuse midline glioma...

Call: SONATA BIS 14 , Panel: NZ3

Principal investigator: dr Katarzyna Leszczyńska

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

CD147 as a novel multifunctional modulator of podocyte metabolism and exosome biogenesis: Identification of new molecula...

Call: OPUS 27 , Panel: NZ4

Principal investigator: dr hab. Agnieszka Piwkowska

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Computational deciphering of pro-ferroptotic cell death protein machinery as a fundamental step in the search for therap...

Call: SONATA BIS 12 , Panel: ST4

Principal investigator: dr hab. Karolina Anna Mikulska-Rumińska

Uniwersytet Mikołaja Kopernika, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Early-life programming for neurodevelopmental disorders: search for a prodrome target within the vascular network in a r...

Call: OPUS 23 , Panel: NZ4

Principal investigator: prof. Małgorzata Maria Filip

Instytut Farmakologii PAN

Yeast DNA topoisomerase II as a model molecular target for novel antifungalcompounds

Call: OPUS 23 , Panel: NZ6

Principal investigator: dr hab. Iwona Aniela Gabriel

Politechnika Gdańska, Wydział Chemiczny

Structural and functional studies of the plant enzymes of arginine metabolism as molecular targets of novel plant protec...

Call: SONATA 17 , Panel: NZ1

Principal investigator: dr Bartosz Sekuła

Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

In search for molecular targets to overcome doxorubicin resistance in triple-negative breast cancer with the use of inno...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Anna Karolina Pogorzelska

Narodowy Instytut Leków

Enzymes of the L-methionine biosynthetic pathway as novel moleculartargets for antifungal chemotherapy

Call: OPUS 20 , Panel: NZ7

Principal investigator: dr hab. Iwona Aniela Gabriel

Politechnika Gdańska, Wydział Chemiczny

The study on the molecular mechanisms of cytotoxic activity of new compounds ZOT5-1-Me and ZOT5-1-Et in an experimental ...

Call: SONATA 16 , Panel: NZ7

Principal investigator: dr Paulina Anna Tokarz

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

New multifunctional drug-like ligands focusing on molecular targets associated with the symptoms and causes of Alzheimer...

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: Anna Marta Pasieka

Uniwersytet Jagielloński, Collegium Medicum

Physical exercise as a natural mechanism inducing neuroregeneration. Search for the new protein markers and therapeutic ...

Call: OPUS 18 , Panel: NZ7

Principal investigator: dr hab. Katarzyna Zofia Kuter-Nowak

Instytut Farmakologii PAN

Exploring influence of inorganic cell microenvironment on NO signalling deregulation in age-related disorders. From mole...

Call: OPUS 18 , Panel: ST4

Principal investigator: prof. Grażyna Jolanta Stochel

Uniwersytet Jagielloński, Wydział Chemii

Prohepcidin as a molecular target of cadmium binding

Call: PRELUDIUM 16 , Panel: ST4

Principal investigator: Dawid Płonka

Instytut Biochemii i Biofizyki PAN

Antiparasitic properties and molecular target identification of new thiosemicarbazide and thiazolidinone derivates in To...

Call: PRELUDIUM 16 , Panel: NZ6

Principal investigator: Adrian Zdzisław Bekier

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Multi-level molecular assessment based on laser microdissection of corneas to reveal biomarkers and therapeutic targets ...

Call: OPUS 16 , Panel: NZ5

Principal investigator: prof. Marzena Magdalena Gajęcka

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

Development of NALDI targets with application of chemically synthesized nanoparticles for detection of natural low molec...

Call: PRELUDIUM 16 , Panel: ST4

Principal investigator: Gulyaim Sagandykova

Uniwersytet Mikołaja Kopernika, Interdyscyplinarne Centrum Nowoczesnych Technologii

Host-pathogen interplay: bacterial outer membrane vesicles as target for complement system.

Call: OPUS 16 , Panel: NZ6

Principal investigator: dr hab. Anna Stanisława Świerzko

Instytut Biologii Medycznej PAN

Understanding the molecular basis of the regulation of activity of lysosome, a potential target of therapeutic intervent...

Call: OPUS 14 , Panel: NZ3

Principal investigator: prof. Magdalena Angelina Gabig-Cimińska

Uniwersytet Gdański, Wydział Biologii

Novel multi-target ligands of aminergic GPCRs as pharmacological tools to study the pathomechanism of schzophrenia

Call: OPUS 14 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Anna Kaczor

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

Novel 2,4-disubstituted pyridine derivatives - synthesis, antimycobacterial activity in vitro, pharmacophore model, mole...

Call: OPUS 13 , Panel: NZ7

Principal investigator: dr hab. Katarzyna Małgorzata Gobis

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

New 2(5H)-furanone derivatives with tailored hydrophobicity of substitutents - synthesis, molecular targets, mechanism o...

Call: OPUS 11 , Panel: NZ7

Principal investigator: prof. Krzysztof Zdzisław Walczak

Politechnika Śląska, Wydział Chemiczny

Multifunctional inhibitors of beta-secretase with anti-aggregating properties of neurotoxic peptides - beta-amyloid and ...

Call: OPUS 11 , Panel: NZ7

Principal investigator: prof. Barbara Antonina Malawska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

INNOvative antiSEPTic agents for a therapy with a broad spectrum of action

Call: OPUS 10 , Panel: NZ7

Principal investigator: dr Sebastian Kraszewski

Politechnika Wrocławska

The participation of low-molecular regulatory RNAs and their target genes in the development of generative organs in yel...

Call: SONATA 10 , Panel: NZ9

Principal investigator: dr Paulina Glazińska

Uniwersytet Mikołaja Kopernika, Wydział Nauk Biologicznych i Weterynaryjnych

Purine salvage pathway enzymes as a target for pathogenic organisma lacking de novo purine synthesis -cas study of Helic...

Call: HARMONIA 7 , Panel: NZ1

Principal investigator: prof. Maria Agnieszka Bzowska

Uniwersytet Warszawski, Wydział Fizyki

Aromatic aminotransferases from Candida albicans as molecular targets for antifungal chemotherapy.

Call: OPUS 9 , Panel: NZ6

Principal investigator: dr Iwona Aniela Gabriel

Politechnika Gdańska, Wydział Chemiczny

Identification and structural characterization of the primordial cytotoxic conformers of the amyloidogenic cascade: Idea...

Call: UNISONO , Panel: NZ1

Principal investigator: prof. Marek Cieplak

Instytut Fizyki PAN

Functional Characterization of Non-Collagenous Extracellular Matrix Proteins as a Potential Molecular Target and Novel B...

Call: SONATA 8 , Panel: NZ5

Principal investigator: dr Michał Andrzej Pawlak

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Identification of proline metabolic pathway as a molecular target for experimental regulation of apoptosis/autophagy in ...

Call: OPUS 7 , Panel: NZ7

Principal investigator: prof. Jerzy Aleksander Pałka

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Inhibition of p21-Activated Kinase (PAK) as a new molecular target in the treatment of chronic myeloid leukemia (CML)

Call: OPUS 6 , Panel: NZ7

Principal investigator: dr hab. Sylwia Flis

Narodowy Instytut Leków

Motor thalamic nuclei as a potential therapeutic target for adenosine in parkinsonian and essential tremor; behavioural,...

Call: OPUS 6 , Panel: NZ4

Principal investigator: dr hab. Jadwiga Wardas

Instytut Farmakologii PAN

The role of poly(ADP-ribose) polymerase and sirtuins in molecular mechanism of cell death. Identification of novel targe...

Call: OPUS 5 , Panel: NZ3

Principal investigator: prof. Joanna Benigna Strosznajder

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Pathogenesis of ovarian cancer survival in non-adhesion conditions: transcriptomic assessment and studies of molecular t...

Call: PRELUDIUM 2 , Panel: NZ1

Principal investigator: dr Anna Stachurska

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie

Human annexin A1 and A2, and their phosphorylated forms, as a molecular target of metal-dependent hydrolysis of peptide ...

Call: SONATA 1 , Panel: NZ1

Principal investigator: dr Tomasz Frączyk

Instytut Biochemii i Biofizyki PAN