Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of poly(ADP-ribose) polymerase and sirtuins in molecular mechanism of cell death. Identification of novel targets for Alzheimer's therapy.

2013/09/B/NZ3/01350

Keywords:

Sirtuins PARPs AD neurodegeneration neuroprotection

Descriptors:

  • NZ3_6: Cell neurobiology
  • NZ7_12: Prevention of human diseases
  • NZ3_3: Apoptosis

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Joanna Strosznajder 

Number of co-investigators in the project: 5

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 490 500 PLN

Project start date (Y-m-d): 2014-04-01

Project end date (Y-m-d): 2017-09-30

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. mini wirówka stołowa do probówek PCR (6 500 PLN)
  2. inkubator z wytrząsaniem do hodowli mikroorganizmów do namnażania plazmidów z wyposażeniem (18 000 PLN)
  3. precyzyjna waga analityczna (8 000 PLN)
  4. oprogramowanie statystyczno-graficzne graphPad prism i oprogramowanie do zarzadzania baza literatury endNote (3 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (16)
  1. Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders.
    Authors:
    Jęśko H, Wencel P, Strosznajder RP, Strosznajder JB.
    Academic press:
    Neurochem Res (rok: 2017, tom: 42, strony: 876-890), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11064-016-2110-y - link to the publication
  2. Alpha-synuclein alters differently gene expression for sirtuins, PARPs and other stress response proteins: implication in neurodegenerative disorders.
    Authors:
    Motyl J, Wencel P, Cieslik M, Strosznajder RP, Strosznajder JB
    Academic press:
    Molecular Neurobiology (rok: 2017, ), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-016-0317-1. - link to the publication
  3. Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity.
    Authors:
    Wencel PL, Lukiw WJ, Strosznajder JB, Strosznajder RP
    Academic press:
    Mol Neurobiol (rok: 2017, ), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-017-0646-8 - link to the publication
  4. Sirtuins and their interactions with transcription factors and poly(ADP-ribose) polymerases.
    Authors:
    Jęśko H, Strosznajder RP.
    Academic press:
    Folia Neuropathol. (rok: 2016, tom: 54(3), strony: 212-233), Wydawca: Termedia
    Status:
    Published
    DOI:
    10.5114/fn.2016.62531 - link to the publication
  5. Inhibition of poly(ADP-ribose) polymerase-1 alters expression of mitochondria-related genes in PC12 cells: Relevance to mitochondrial homeostasis in neurodegenerative disorders.
    Authors:
    Czapski GA, Cieślik M, Wencel PL, Wójtowicz S, Strosznajder RP, Strosznajder JB.
    Academic press:
    Biochim Biophys Acta (rok: 2017, tom: 1865(2), strony: 281-288.), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2017.11.003. - link to the publication
  6. The Molecular Mechanism of Amyloid β42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins.
    Authors:
    Cieślik M, Czapski GA, Strosznajder JB
    Academic press:
    PLoS One (rok: 2015, tom: 10(9), strony: 10(9):e0137193), Wydawca: Indian Institute of Toxicology Research
    Status:
    Published
    DOI:
    10.1371/journal.pone.0137193 - link to the publication
  1. Alteration of sphingosine kinase 1 by amyloid beta 1-42 and its implication in cell death.
    Authors:
    Cieślik M, Czapski G, Strosznajder J
    Conference:
    12th International Symposium Molecular basis of pathology and therapy in neurological disorders" 20-21. Nov.2014 Warszawa, Poland (rok: 2014, ), Wydawca: Termedia
    Data:
    konferencja 20-21. Nov.2014
    Status:
    Published
  2. Interplay between bioactive lipids and presynaptic proteins – critical in initiation and progression of neurodegenerative disorders.
    Authors:
    Joanna B. Strosznajder
    Conference:
    The Neurochemical Conference 2017 "Advances in molecular and epigenetic mechanisms in neurodegeneration and neuroinflammation: novel therapeutic approaches" (rok: 2017, ), Wydawca: Termedia
    Data:
    konferencja 19-20.10.2017
    Status:
    Published
  3. Pharmacological inhibition of PARP-1 in experimental model of Alzheimer's disease: the cross-talk between PARPs and Sirtuins in regulation of cell's fate.
    Authors:
    Przemysław L. Wencel, Walter J. Lukiw, Joanna B. Strosznajder, Robert P. Strosznajder
    Conference:
    The Neurochemical Conference 2017 "Advances in molecular and epigenetic mechanisms in neurodegeneration and neuroinflammation: novel therapeutic approaches" (rok: 2017, ), Wydawca: Termedia
    Data:
    konferencja October 19-20, 2017, Warsaw, Poland
    Status:
    Published
  4. The molecular network between amyloid β peptide, sphingosine kinase and sirtuins in cell survival and death. Implication in Alzheimer's disease
    Authors:
    Joanna B. Strosznajder, Grzegorz A. Czapski, Magdalena Cieślik,
    Conference:
    12th International Congress of the Polish Neuroscience Society, 6-8 Sep. 2015,Gdańsk, Poland (rok: 2015, ), Wydawca: Acta Neurobiol. Exp 75,2015 Suppl
    Data:
    konferencja 6-8 Sep. 2015
    Status:
    Published
  5. Poly(ADP-ribose)polymerases and Sirtuins the Promising Targets for Novel Natural Compounds Against Amyloidogenic Proteins Toxicity
    Authors:
    Strosznajder JB, Wencel P, Strosznajder RP
    Conference:
    5th International Conference and Exhibition on Natural & Alternative Medicine, Beijing, China (rok: 2016, ), Wydawca: Alternative&Integrative Medicine, Omics Publ Gr
    Data:
    konferencja Sep. 5-7, 2016
    Status:
    Published
    DOI:
    link to the publication
  6. The effect of poly(ADP-ribose) polymerase-1 inhibition on expression of antioxidative and mitochondria-related genes: relevance to pathomechanism of Alzheimer's disease.
    Authors:
    Grzegorz A. Czapski, Magdalena Cieślik, Przemysław L. Wencel, Sylwia Wójtowicz, Robert P. Strosznajder, Joanna B. Strosznajder
    Conference:
    The Neurochemical Conference 2017 "Advances in molecular and epigenetic mechanisms in neurodegeneration and neuroinflammation: novel therapeutic approaches" (rok: 2017, ), Wydawca: Termedia
    Data:
    konferencja October 19-20, 2017, Warsaw, Poland
    Status:
    Published
  7. PARP-1 inhibition modulates gene expression of mitochondria Sirtuins and APP secretases. The role of PARP and Sirts interaction in amyloid beta toxicity.
    Authors:
    Strosznajder JB, Wencel P, Strosznajder RP
    Conference:
    2nd International Conference on Central Nervous System Disorders and Therapeutics" Dubaj, UAE (rok: 2016, ), Wydawca: J Neurol Neurophysiol, Omics Publ Gr
    Data:
    konferencja December 5-7, 2016
    Status:
    Published
    DOI:
    link to the publication
  8. The interplay between amyloid β42 peptide, sphingosine kinase-1 and mitochondrial sirtuins in cell survival and death: implication in Alzheimer's Disease
    Authors:
    Magdalena Cieślik, Grzegorz A. Czapski, Joanna B. Strosznajder
    Conference:
    Neurochemical Conference "Neuropsychoimmunological mechanisms in the pathology of neurodegenerative diseases. From biomarkers to therapeutics." 22-23 Oct. 2015, Warsaw, Poland (rok: 2015, ), Wydawca: Folia Neuropathol. 2015,53,4,p412,B5, Termedia
    Data:
    konferencja 22-23 Oct. 2015
    Status:
    Published
  9. Amyloid B (1-42) oligomers alter expression of mitochondria-related genes and viability of neuronal and microglial cells: the role of microglia-secreted factor(s) in neuroprotection
    Authors:
    JB Strosznajder, M Cieslik, S Wójtowicz, PL Wencel, GA Czapski, RP Strosznajder
    Conference:
    ISN Symposium on metabolic and redox interactions between neurons and astrocytes in health and disease. (rok: 2017, ), Wydawca: Uniwersytet w Salamance, książka abstraktów
    Data:
    konferencja 26-28.06.2017
    Status:
    Published
  10. Amyloid beta oligomers alter transcription of genes involved in stress response and mitochondrial function differently in neuronal and microglial cells: implication in Alzheimer's disease.
    Authors:
    Magdalena Cieślik, Grzegorz A. Czapski, Sylwia Wójtowicz, Joanna B. Strosznajder
    Conference:
    The Neurochemical Conference 2017 "Advances in molecular and epigenetic mechanisms in neurodegeneration and neuroinflammation: novel therapeutic approaches" (rok: 2017, ), Wydawca: Termedia
    Data:
    konferencja October 19-20, 2017, Warsaw, Poland
    Status:
    Published
  11. Mechanism of amyloid beta peptides and alfa synuclein cytotoxicity. The role of PARPs and sirtuins. Implications in Alzheimer's disease
    Authors:
    Wencel P, Motyl J, Strosznajder JB, Strosznajder RP
    Conference:
    29th ECNP Congress For the science and treatment of disorders of the brain (rok: 2016, ), Wydawca: Elsevier
    Data:
    konferencja September 17-20,2016
    Status:
    Published
  12. Transcriptional alterations of mitochondrial proteins in microglial BV2 cells exposed to Alzheimer's amyloid beta1-42 oligomers. The role of sirtuins.
    Authors:
    Magdalena Cieślik, Grzegorz A. Czapski, Sylwia Wójtowicz, Joanna B. Strosznajder
    Conference:
    the 8th International Symposium on Experimental and Clinical Neurobiology (rok: 2017, ), Wydawca: SAS książka abstraktów
    Data:
    konferencja 18-21.06.2017 Kosice Slovakia
    Status:
    Published
  13. Amyloid beta and its role in regulation of gene expression for APP cleaving enzymes. Implication in Alzheimer's pathology
    Authors:
    Przemysław Wencel, Robert P. Strosznajder
    Conference:
    Neurochemical Conference "Neuropsychoimmunological mechanisms in the pathology of neurodegenerative diseases. From biomarkers to therapeutics." 22-23 Oct. 2015, Warsaw, Poland (rok: 2015, ), Wydawca: Folia Neuropathologica 2015; 53/4 Termedia
    Data:
    konferencja 22-23 Oct. 2015
    Status:
    Published
  14. Interference between PARP-1 and Sirtuins :the role in regulation of gene expression and mitochondria function in model of Alzheimer's Disease.
    Authors:
    Joanna B. Strosznajder, Przemysław Wencel, Grzegorz A. Czapski, Magdalena Cieślik. Robert P. Strosznajder,
    Conference:
    the 13th International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders (rok: 2017, ), Wydawca: Karger, Neurodegener Dis 2017, 17 , suppl 1, 8-590
    Data:
    konferencja 29.03-2.04.2017
    Status:
    Published
  15. PARP-1 and its role in transcription of mitochondrial respiratory complexes and enzymes of antyoxidative defence under basal conditions and in Amyloid Beta toxicity
    Authors:
    Cieslik M, Baranski D, Wencel P, Czapski GA, Strosznajder RP, Strosznajder JB
    Conference:
    Joint Conference The 13th International Symposium Molecular Basis of Pathology and Therapy in Neurological Disorders The 4th International Conference Stem Cells: Therapeutic Outlook for Central Nervous System Disorders (rok: 2016, ), Wydawca: Folia Neuropathol, Termedia
    Data:
    konferencja November 17-18, 2016
    Status:
    Published
    DOI:
    link to the publication
  16. Poly(ADP-ribose) polymerase-1 as a crucial regulator of nuclear and mitochondrial Sirtuins transcription. Implications for cell physiology and pathology
    Authors:
    Wencel PL, Strosznajder JB, Strosznajder RP
    Conference:
    •Joint Conference The 13th International Symposium Molecular Basis of Pathology and Therapy in Neurological Disorders The 4th International Conference Stem Cells: Therapeutic Outlook for Central Nervous System Disorders (rok: 2016, ), Wydawca: Folia Neuropathol Termedia
    Data:
    konferencja November 17-18, 2016
    Status:
    Published
    DOI:
    link to the publication

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