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Exploring influence of inorganic cell microenvironment on NO signalling deregulation in age-related disorders. From molecular mechanistic insight in model systems to new therapeutic targets.

2019/35/B/ST4/04266

Keywords

Descriptors

  • ST4_009: Chemia biologiczna
  • ST4_017: Reakcje chemiczne: mechanizmy, termodynamika, kinetyka
  • ST4_014: Kataliza

Panel

ST4 – Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution

Uniwersytet Jagielloński, Wydział Chemii

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Grażyna Jolanta Stochel

Number of co-investigators in the project: 17

Call

OPUS 18 – announced on 2019-09-16

Amount awarded
1 996 212 PLN
Project start date
2020-07-06
Project end date
2026-05-05
Project duration
70 months (the same as in the proposal)
Project status
Project completed

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (10)

  1. High-Pressure Mechanistic Insight into Bioinorganic NO Chemistry

    Authors:
    Łukasz Orzeł, Maria Oszajca, Justyna Polaczek, Dominika Porębska, Rudi van Eldik, Grażyna Stochel
    Academic press:
    Molecules (year: 2021, volume: 26 art. 4947, pages: 46046), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26164947 – link to the publication

  2. Investigation of the Immunogenic Properties of Ovalbumin Modified by Urban Airborne Particulate Matter

    Authors:
    B. Nowak, A. Wądołek, O. Mazuryk, A. Poznańska, K. Majzner, G. Majka, M. Oszajca, M. Barańska, G. Stochel, J. Marcinkiewicz
    Academic press:
    Archivum Immunologiae et Therapiae Experimentalis (year: 2023, volume: 71, art. 13, pages: 46036), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00005-023-00679-8 – link to the publication

  3. Blood Plasma's Protective Ability against the Degradation of S-Nitrosoglutathione under the Influence of Air-Pollution-Derived Metal Ions in Patients with Exacerbation of Heart Failure and Coronary Artery Disease

    Authors:
    Anna Wądołek, Dominika Drwiła, Maria Oszajca, Grażyna Stochel, Ewa Konduracka, Małgorzata Brindell
    Academic press:
    International Journal of Molecular Science (year: 2021, volume: 22 art. 10500, pages: 46041), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms221910500 – link to the publication

  4. Ligand-Tuning of the Stability of Pd(II) Conjugates with Cyanocobalamin

    Authors:
    Dominika Porębska, Łukasz Orzeł, Dorota Rutkowska-Zbik, Grażyna Stochel, Rudi van Eldik
    Academic press:
    International Journal of Molecular Science (year: 2021, volume: 22, art. 7973, pages: 46038), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22157973 – link to the publication

  5. Synthesis and characterization of cyanocobalamin conjugates with Pt(II) complexes towards potential therapeutic applications

    Authors:
    D. Porębska, Ł. Orzeł, D. Rutkowska-Żbik, G. Stochel, R. van Eldik
    Academic press:
    Polyhedron (year: 2023, volume: 230 art. 116230, pages: 46031), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.poly.2022.116230 – link to the publication

  6. Unraveling the molecular mechanism of S-nitrosation mediated by N-acetylmicroperoxidase-11

    Authors:
    M. Oszajca, A. Jodłowska, D. Rutkowska-Zbik, K. Kieca, G. Stochel
    Academic press:
    Inorganic Chemistry (year: 2023, volume: 62, pages: 5630–5643), Publisher: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.3c00180 – link to the publication

  7. Heme-Thiolate-Mediated Formation of S-Nitrosothiols and NO-Ferroheme: Mechanistic Insights

    Authors:
    Konrad Kieca, Dorota Rutkowska-Zbik, Szymon Wierzbicki, Krzysztof Kruczała, Grażyna Stochel, Maria Oszajca
    Academic press:
    ChemCatChem (year: 2025, volume: 17, art. e00668, pages: 46032), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1002/cctc.202500668 – link to the publication

  8. A Personal Account on Inorganic Reaction Mechanisms

    Authors:
    J. Polaczek, K. Kieca, M. Oszajca, O. Impert, A. Katafias, D. Chatterjee, D. Ćoćić, R. Puchta, G. Stochel, C.D. Hubbard, R. van Eldik
    Academic press:
    THE CHEMICAL RECORD (year: 2023, volume: 23, art. e202300278, pages: 46053), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1002/tcr.202300278 – link to the publication

  9. Nitric Oxide Signaling and Sensing in Age-Related Diseases

    Authors:
    1.O. Mazuryk, I. Gurgul, M. Oszajca, J. Polaczek, K. Kieca, E. Bieszczad-Żak, T. Martyka, G. Stochel
    Academic press:
    Antioxidants (year: 2024, volume: 13 art. 1213, pages: 14246), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox13101213 – link to the publication

  10. Enhancement of NO release from S-nitrosoalbumin by pollution derived metal ions

    Authors:
    Anna Wądołek, Maria Oszajca, Wiktoria Pęcak, Małgorzata Brindell, Grażyna Stochel
    Academic press:
    Dalton Transaction (year: 2021, volume: 50, pages: 9923-9933), Publisher: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d1dt01260f – link to the publication

Book publications / chapters in book publications (1)

  1. Mechanistic insight into photoactivation of small inorganic molecules from the biomedical application perspectives

    Authors:
    1.A. Kyzioł, Ł. Orzeł, I. Gurgul, O. Mazuryk, P. Łabuz, G. Stochel
    Book:
    Advances in Inorganic Chemistry (year: 2022, volume: vol. 80, Biomedical Applications of Inorganic Photochemistry, pages: 233-284), Publisher: Elsevier, Academic Press
    Status:
    Published
    DOI:
    10.1016/S0898-8838(22)00043-5 – link to the publication

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