Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Molecular background of brain metastases in lung cancer

2016/23/D/NZ2/02890

Keywords:

non-small cell lung cancer adenocarcinoma squamous-cell carcinoma small cell lung cancer brain metastases next-generation-sequencing driver mutations molecularly targeted therapies

Descriptors:

  • NZ2_1: Molecular genetics
  • NZ2_6: Immunogenetics
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Medyczny w Lublinie, Wydział Lekarski

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marcin Nicoś 

Number of co-investigators in the project: 5

Call: SONATA 12 - announced on 2016-09-15

Amount awarded: 1 483 700 PLN

Project start date (Y-m-d): 2017-08-30

Project end date (Y-m-d): 2022-08-29

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Bio - analizator Agilent 2100 (150 000 PLN)
  2. Termocyklera - Biometra TRIO.
  3. Concentrator Plus.
  4. Ultrasonikator Covaris M220 (100 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. The Role of Intratumor Heterogeneity in the Response of Metastatic Non-Small Cell Lung Cancer to Immune Checkpoint Inhibitors
    Authors:
    Marcin Nicoś, Paweł Krawczyk, Nicola Crosetto, Janusz Milanowski
    Academic press:
    Frontiers in Oncology (rok: 2020, tom: 10, strony: online: [art. nr] 569202), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fonc.2020.569202 - link to the publication
  2. Genetic Clonality as the Hallmark Driving Evolution of Non-Small Cell Lung Cancer
    Authors:
    Marcin Nicoś, Paweł Krawczyk
    Academic press:
    Cancers (rok: 2022, tom: 14, strony: 1813), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers14071813 - link to the publication
  3. Genomic Profiling Identifies Putative Pathogenic Alterations in NSCLC Brain Metastases
    Authors:
    Marcin Nicoś, Luuk Harbers, Enrico Patrucco, Maximilian Kramer-Drauberg, Xiaolu Zhang, Claudia Voena, Anna Kowalczyk, Aleksandra Bożyk, Rafał Pęksa, Bożena Jarosz, Justyna Szumiło, Michele Simonetti, Monika Żuk, Bartosz Wasąg, Katarzyna Reszka, Renata Duchnowska, Janusz Milanowski, Roberto Chiarle, Magda Bienko, Paweł Krawczyk, Jacek Jassem, Chiara Ambrogio & Nicola Crosetto
    Academic press:
    JTO Clinical and Research Reports (rok: 2022, tom: 45363, strony: 100535), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jtocrr.2022.100435 - link to the publication
  4. Deep learning-based tumor microenvironment segmentation is predictive of tumor mutations and patient survival in non-small-cell lung cancer
    Authors:
    Łukasz Rączkowski, Iwona Paśnik, Michał Kukiełka, Marcin Nicoś, Magdalena A. Budzinska, Tomasz Kucharczyk, Justyna Szumiło, Paweł Krawczyk, Nicola Crosetto, Ewa Szczurek
    Academic press:
    BMC Cancer (rok: 2022, tom: 22, strony: 1001), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12885-022-10081-w - link to the publication
  5. Somatic copy number alterations in human cancers: an analysis of publicly available data from The Cancer Genome Atlas.
    Authors:
    Luuk Harbers, Federico Agostini, Marcin Nicoś, Dimitri Poddighe, Magda Bienko, Nicola Crosetto.
    Academic press:
    Frontiers in Oncology (rok: 2021, tom: 11, strony: online: [art. nr] 700568), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fonc.2021.700568 - link to the publication

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