Projects funded by the NCN
Identification and targeting molecular drug resistance mechanisms in adult B-cell acute lymphoblastic leukemia
2011/01/B/NZ4/04829
Keywords:
acute lymphoblastic leukemia HIF-1 alpha ERK DNA damage drug resistance mechanisms targeted therapy
Descriptors:
- NZ4_11: Metabolism
- NZ5_3: Pathogenesis of human diseases
- NZ5_7: Human disease treatment
Panel:
NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology
Host institution :
Instytut Hematologii i Transfuzjologii
woj. mazowieckie
Principal investigator (from the host institution):
dr hab. Przemysław Juszczyński
Number of co-investigators in the project: 4
Call: OPUS 1 - announced on 2011-03-15
Amount awarded: 488 000 PLN
Project start date (Y-m-d): 2011-12-16
Project end date (Y-m-d): 2015-06-15
Project duration:: 42 months (the same as in the proposal)
Project status: Project settled
Equipment purchased [PL]
- Zestaw do elektroferezy Comet Assay (15 000 PLN)
- Automatyczny licznik i analizator komórkowy Countess (28 000 PLN)
- Komora laminarna.
Information in the final report
- Publication in academic press/journals (1)
- Articles in post-conference publications (1)
- MEK Inhibition Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells to Dexamethasone through Modulation of mTOR Activity and Stimulation of AutophagyAuthors:Anna Polak, Przemyslaw Kiliszek, Tomasz Sewastianik, Maciej Szydlowski, Ewa Jablonska, Emilia Bialopiotrowicz, Patryk Gorniak, Sergiusz Markowicz, Eliza Nowak, Monika A. Grygorowicz, Dominika Nowis, Jakub Golab, Sebastian Giebel, Ewa Lech-Maranda, Krzysztof Warzocha, Przemyslaw JuszczynskiAcademic press:PLOS One (rok: 2016, tom: 11, strony: n/a), Wydawca: PLOSStatus:PublishedDOI:10.1371/journal.pone.0155893 - link to the publication
- MEK1 inhibitor selumetinib sensitizes B-cell acute lymphoblastic leukemia (B-ALL) cells to dexamethasone by modulating autophagyAuthors:Polak A, Kiliszek P, Sewastianik T., Szydlowski M., Jablonska E., Prusisz W., Bialopiotrowicz E., Markowicz S., Nowak E., Grygorowicz M., Nowis D., Bojarczuk K., Golab J., Juszczynski PConference:19th Congress of the European Hematology Association, 12-15 June, 2014, Milan, Italy (rok: 2014, ), Wydawca: European Hematology AssociationData:konferencja 12-15 June, 2014, Milan, ItalyStatus:Published