Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Molecular insights into hypoxic tumors – for development of targeted cancer therapeutics

2022/47/P/NZ5/01156

Keywords:

DNA damage G-quadruplex Hypoxia Oxidative damage Photodynamic therapy Photosensitizers

Descriptors:

  • NZ5_007:
  • NZ5_009:
  • NZ7_014:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Politechnika Wrocławska

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marco Deiana 

Number of co-investigators in the project: 3

Call: POLONEZ BIS 3 - announced on 2022-07-15

Amount awarded: 1 202 944 PLN

Project start date (Y-m-d): 2023-10-01

Project end date (Y-m-d): 2025-09-30

Project duration:: 24 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Heavy-atom-free π-twisted photosensitizers for fluorescence bioimaging and photodynamic therapy
    Authors:
    Sánchez, Darío Puchán Morice, Korentin Mutovska, Monika G. Khrouz, Lhoussain Josse, Pierre Allain, Magali Gohier, Frédéric Blanchard, Philippe Monnereau, Cyrille Le Bahers, Tangui Sabouri, Nasim Zagranyarski, Yulian Cabanetos, Clement Deiana, Marco
    Academic press:
    Journal of Materials Chemistry B (rok: 2024, tom: 12, strony: 8107-8121), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D4TB01014K - link to the publication
  2. A Rationally Designed Azobenzene Photoswitch for DNA G-Quadruplex Regulation in Live Cells
    Authors:
    Dudek, Marta López-Pacios, Lucia Sabouri, Nasim Nogueira, Juan Martinez-Fernandez, Lara Deiana, Marco
    Academic press:
    Angewandte Chemie International Edition (rok: 2025, tom: 64, strony: e202413000 (1 of 12)), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/anie.202413000 - link to the publication
  3. Harnessing Light for G-Quadruplex Modulation: Dual Isomeric Effects of an Ortho-Fluoroazobenzene Derivative
    Authors:
    Dudek, Marta López-Pacios, Lucía Sabouri, Nasim Nogueira, Juan J. Martinez-Fernandez, Lara Deiana, Marco
    Academic press:
    The Journal of Physical Chemistry Letters (rok: 2024, tom: 15, strony: 9757-9765), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpclett.4c02285 - link to the publication
  4. Advancements in molecular disassembly of optical probes: a paradigm shift in sensing, bioimaging, and therapeutics
    Authors:
    Saczuk, Karolina Dudek, Marta Matczyszyn, Katarzyna Deiana, Marco
    Academic press:
    Nanoscale Horizons (rok: 2024, tom: 9, strony: 1390-1416), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D4NH00186A - link to the publication

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