Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Investigation of the molecular mechanisms of anti-leukemic activity of SK053, a small molecule compound targeting enzymes involved in allosteric disulphide bonds formation

2013/10/E/NZ5/00778

Keywords:

acute myeloid leukemia thioredoxin protein disulphide isomerase

Descriptors:

  • NZ5_7: Human disease treatment
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Dominika Nowis 

Number of co-investigators in the project: 5

Call: SONATA BIS 3 - announced on 2013-06-14

Amount awarded: 1 180 714 PLN

Project start date (Y-m-d): 2014-07-04

Project end date (Y-m-d): 2017-07-03

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Blotter.
  2. Mikrowirówka.
  3. Oprogramowanie komputerowe.
  4. Spektrofotometr typu Nanodrop (45 000 PLN)
  5. Termocykler z funkcją gradientu (35 000 PLN)
  6. Mikroskop odwrócony z cyfrową kamerą.
  7. Ława (komora) laminarna wraz z wyposażeniem (32 123 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (2)
  1. Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma
    Authors:
    Trzeciecka A, Klossowski S, Bajor M, Zagozdzon R, Gaj P, Muchowicz A, Malinowska A, Czerwoniec A, Barankiewicz J, Domagala A, Chlebowska J, Prochorec-Sobieszek M, Winiarska M, Ostaszewski R, Golab J, Nowis D, Firczuk M
    Academic press:
    Oncotarget (rok: 2016, tom: 7, strony: 1717-31), Wydawca: Impact Journals, LLC.
    Status:
    Published
    DOI:
    10.18632/oncotarget.6435. - link to the publication
  2. Inhibition of protein disulphide isomerase induces differentiation of AML cells
    Authors:
    Chlebowska-Tuz J, Gaj P, Lazniewski M, Firczuk M, Borowiec K, Sas-Nowosielska H, Bajor M, Malinowska A, Muchowicz M, Stawinski P, Sokolowska O, Sobczak M, Pilch Z, Rodziewicz-Lurzynska A, Giannopoulos K, Juszczynski P, Basak GW, Dziembowski A, Plewczynski D, Jazdzewski K, Ploski R, Golab J, Nowis D
    Academic press:
    Haematologica (rok: 2018, tom: 103(11), strony: 1843-1852), Wydawca: FERRATA STORTI FOUNDATION
    Status:
    Published
    DOI:
    10.3324/haematol.2018.190231 - link to the publication
  3. Stres siateczki śródplazmatycznej i stres oksydacyjny w ostrych białaczkach szpikowych
    Authors:
    Chlebowska J
    Academic press:
    Acta Haematologica Polonica (rok: 2016, tom: 47, strony: 197-204), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.achaem.2016.07.001 - link to the publication
  1. SK053, an Inhibitor of Enzymes Involved in Allosteric Disulfide Bonds Formation, Targets Expression of Histone Genes and Induces Differentiation of Human AML Cells
    Authors:
    Chlebowska J, Gaj P, Stawinski P, Lazniewski M, Firczuk M, Furs K, Sadowski R, Klossowski S, Ostaszewski R, Golab J, Giannopoulos K, Ploski R, Nowis D
    Conference:
    56th ASH Meeting and Exposition (rok: 2014, ), Wydawca: American Society of Hematology
    Data:
    konferencja 6-9.12.2014
    Status:
    Published
    DOI:
    link to the publication
  2. Abstract 4501: Immunophenotypic identities of clinical samples have the potential to correlate with overall survival in cytogenetically normal AML patients
    Authors:
    Gaj P, Nowis D, Volinia S
    Conference:
    AACR 107th Annual Meeting 2016 (rok: 2016, ), Wydawca: American Association for Cancer Research
    Data:
    konferencja 16-20.04.2016
    Status:
    Published

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