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Investigation of the molecular mechanisms of anti-leukemic activity of SK053, a small molecule compound targeting enzymes involved in allosteric disulphide bonds formation

2013/10/E/NZ5/00778

Keywords

Descriptors

  • NZ5_7: Leczenie chorób człowieka
  • NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Dominika Anna Nowis

Number of co-investigators in the project: 5

Call

SONATA BIS 3 – announced on 2013-06-14

Amount awarded
1 180 714 PLN
Project start date
2014-07-04
Project end date
2017-07-03
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Blotter.
  2. Mikroskop odwrócony z cyfrową kamerą.
  3. Mikrowirówka.
  4. Oprogramowanie komputerowe.
  5. Spektrofotometr typu Nanodrop. Cost: 45 000 PLN
  6. Termocykler z funkcją gradientu. Cost: 35 000 PLN
  7. Ława (komora) laminarna wraz z wyposażeniem. Cost: 32 123 PLN

Information in the final report

Publication in academic press/journals (3)

  1. Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma

    Authors:
    Trzeciecka A, Klossowski S, Bajor M, Zagozdzon R, Gaj P, Muchowicz A, Malinowska A, Czerwoniec A, Barankiewicz J, Domagala A, Chlebowska J, Prochorec-Sobieszek M, Winiarska M, Ostaszewski R, Golab J, Nowis D, Firczuk M
    Academic press:
    Oncotarget (year: 2016, volume: 7, pages: 1717-31), Publisher: Impact Journals, LLC.
    Status:
    Published
    DOI:
    10.18632/oncotarget.6435. – link to the publication

  2. Inhibition of protein disulphide isomerase induces differentiation of AML cells

    Authors:
    Chlebowska-Tuz J, Gaj P, Lazniewski M, Firczuk M, Borowiec K, Sas-Nowosielska H, Bajor M, Malinowska A, Muchowicz M, Stawinski P, Sokolowska O, Sobczak M, Pilch Z, Rodziewicz-Lurzynska A, Giannopoulos K, Juszczynski P, Basak GW, Dziembowski A, Plewczynski D, Jazdzewski K, Ploski R, Golab J, Nowis D
    Academic press:
    Haematologica (year: 2018, volume: 103(11), pages: 1843-1852), Publisher: FERRATA STORTI FOUNDATION
    Status:
    Published
    DOI:
    10.3324/haematol.2018.190231 – link to the publication

  3. Stres siateczki śródplazmatycznej i stres oksydacyjny w ostrych białaczkach szpikowych

    Authors:
    Chlebowska J
    Academic press:
    Acta Haematologica Polonica (year: 2016, volume: 47, pages: 197-204), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.achaem.2016.07.001 – link to the publication

Articles in post-conference publications (2)

  1. Abstract 4501: Immunophenotypic identities of clinical samples have the potential to correlate with overall survival in cytogenetically normal AML patients

    Authors:
    Gaj P, Nowis D, Volinia S
    Conference:
    AACR 107th Annual Meeting 2016 (year: 2016, pages: 4501), Publisher: American Association for Cancer Research
    Date:
    conference 16-20.04.2016
    Status:
    Published

  2. SK053, an Inhibitor of Enzymes Involved in Allosteric Disulfide Bonds Formation, Targets Expression of Histone Genes and Induces Differentiation of Human AML Cells

    Authors:
    Chlebowska J, Gaj P, Stawinski P, Lazniewski M, Firczuk M, Furs K, Sadowski R, Klossowski S, Ostaszewski R, Golab J, Giannopoulos K, Ploski R, Nowis D
    Conference:
    56th ASH Meeting and Exposition (year: 2014, pages: Blood 2014 124:3503), Publisher: American Society of Hematology
    Date:
    conference 6-9.12.2014
    Status:
    Published
    DOI:
    link to the publication

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