Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Hyphenated separation techniques in the study of the molecular mechanisms of metabolic biotransformation of drugs for targeted drug therapy

2016/23/D/ST4/00305

Keywords:

metabolism mass spectroemtry liquid chromatography biologically active compounds electrochemistry in vitro in vivo

Descriptors:

  • ST4_6: Instrumental methods in chemistry
  • ST4_3: Molecular architecture and structure

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Mikołaja Kopernika, Wydział Chemii

woj. kujawsko-pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Małgorzata Szultka-Młyńska 

Number of co-investigators in the project: 3

Call: SONATA 12 - announced on 2016-09-15

Amount awarded: 294 200 PLN

Project start date (Y-m-d): 2017-07-28

Project end date (Y-m-d): 2020-07-27

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Mikrocela do reaktora elektrochemicznego (35 000 PLN)
  2. System do badania uwalniania substancji czynnych (85 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (7)
  • Book publications / chapters in book publications (3)
  1. Electrochemical oxidation of selected immunosuppressants and identification of their oxidation products by means of liquid chromatography and tandem mass spectrometry (EC-HPLC-MS/MS)
    Authors:
    M. Szultka-Młyńska, B. Buszewski
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2019, tom: 176, strony: 45302), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2019.112799 - link to the publication
  2. Identification of in vitro and in vivo potential metabolites of novel cardiovascular and adrenolytic drugs by liquid chromatography-mass spectrometry with the aid of experimental design
    Authors:
    M. Szultka-Młyńska, K. Pauter, B. Buszewski
    Academic press:
    Nova Biotechnologica et Chimica (rok: 2019, tom: 18(2), strony: 45300), Wydawca: sciendo
    Status:
    Published
    DOI:
    10.2478/nbec-2019-0021 - link to the publication
  3. Electrochemical simulation of three novel cardiovascular drugs phase I metabolism and development of a new method for determination of them by liquid chromatography coupled with tandem mass spectrometry
    Authors:
    M. Szultka-Młyńska, S. Bajkacz, M. Kaca, I. Baranowska, B. Buszewski
    Academic press:
    Journal of Chromatography B (rok: 2018, tom: 1093-1094, strony: 100-112), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jchromb.2018.07.002 - link to the publication
  4. Study of chromatographic behavior of antibiotic drugs and their metabolites based on quantitative structure-retention relationships with the use of HPLC-DAD
    Authors:
    J. Walczak-Skierska, M. Szultka-Młyńska, K. Pauter, B. Buszewski
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2020, tom: 184, strony: 45303), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2020.113187 - link to the publication
  1. Application of liquid chromatography/mass spectrometry for electrochemical oxidation of psychotropic drugs in comparison to in vitro and in vivo methods
    Authors:
    P. Jerszyńska, M. Szultka-Młyńska, B. Buszewski
    Conference:
    Analytical methods to study oxidative damage, antioxidants and drugs (rok: 2018, ), Wydawca: Medical University of Białystok
    Data:
    konferencja 24-26.V.2018
    Status:
    Published
  2. Liquid chromatographic determination of antibiotics and its metabolites in water conditions
    Authors:
    J. Walczak, M. Szultka-Młyńska, K. Pauter, B. Buszewski
    Conference:
    6. Konferencja Naukowa, Monitoring i analiza wody. Chromatograficzne metody oznaczania substancji o charakterze jonowym (rok: 2019, ), Wydawca: Organizator konferencji
    Data:
    konferencja 10-12.III.2019
    Status:
    Published
  3. Metabolic studies of selected immunosuppressant drugs based on electrochemical simulation in comparison to in vivo and in vitro methods
    Authors:
    M. Szultka-Młyńska, B. Buszewski
    Conference:
    Conference of Polish Mass Spectrometry Society (rok: 2018, ), Wydawca: Institute of Organic Chemistry, Polish Academy of Sciences
    Data:
    konferencja 23-26.IV.2018
    Status:
    Published
  4. Electrochemistry/electrospray ionization mass spectrometry (EC-ESI-MS) for the study of drugs from different therapeutic groups oxidation products as possible metabolites for the purposes of biomedical diagnostics
    Authors:
    M. Szultka-Młyńska, B. Buszewski
    Conference:
    Conference of Polish Mass Spectrometry Society (rok: 2018, ), Wydawca: Institute of Organic Chemistry, Polish Academy of Sciences
    Data:
    konferencja 23-26.IV.2018
    Status:
    Published
  5. Hyphenated separation techniques in the study of in vitro and in vivo drug metabolism for targeted pharmacological therapy
    Authors:
    M. Szultka-Młyńska, B. Buszewski
    Conference:
    Metabolomics Circle 2017 (rok: 2017, ), Wydawca: Medical Research Journal
    Data:
    konferencja 17-18.XI.2017
    Status:
    Published
  6. ELECTROCHEMISTRY/ELECTROSPRAY IONIZATION MASS SPECTROMETRY (EC-ESI-MS) FOR THE STUDY OF DRUGS FROM DIFFERENT THERAPEUTIC GROUPS OXIDATION PRODUCTS AS POSSIBLE METABOLITES FOR THE PURPOSES OF BIOMEDICAL DIAGNOSTIC
    Authors:
    M. Szultka-Młyńska, B. Buszewski
    Conference:
    48TH International Symposium on High-Performance Liquid Phase Separations and Related Techniques (rok: 2019, ), Wydawca: University of Milano-Bicocca, Milan
    Data:
    konferencja 16-20.VI.2019
    Status:
    Published
  7. Zastosowanie elektrochemii oraz spketrometrii mas w badaniu produktów metabolizmu leków dla potrzeb celowanej terapii farmakologicznej
    Authors:
    M. Szultka-Młyńska, B. Buszewski
    Conference:
    Polska Konferencja Chemii Analitycznej (rok: 2018, ), Wydawca: Wydawnictwo MALAMUT Al. Wilanowska 41/5, 02-765 Warszawa
    Data:
    konferencja 1-5.VII.2018
    Status:
    Published
  1. Zastosowanie elektrochemii oraz spektrometrii mas w badaniu produktów metabolizmu leków psychotropowych dla potrzeb diagnostyki biomedycznej
    Authors:
    M. Szultka-Młyńska, B. Buszewski
    Book:
    Elektroanaliza : sensory i metody pomiarowe (rok: 2019, tom: -, strony: 233-245), Wydawca: Kraków: Wydawnictwo Naukowe "Akapit"
    Status:
    Published
  2. Bioanalityka w transformacji in vitro i in vivo związków biologicznie aktywnych dla potrzeb diagnostyki biomedycznej
    Authors:
    M. Szultka-Młyńska, K. Pauter, J. Walczak, B. Buszewski
    Book:
    Bioanalityka w nauce i w życiu Tom 1 (rok: 2020, tom: 1, strony: 45372), Wydawca: PWN
    Status:
    Published
  3. Inorganic oxide and chemically bonded sorbents
    Authors:
    M. Szultka-Młyńska, H.H. Al-Suod, B. Buszewski
    Book:
    Solid-phase extraction (rok: 2020, tom: -, strony: 37-54), Wydawca: Amsterdam: Elsevier
    Status:
    Published

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