Projects funded by the NCN
Antiparasitic properties and molecular target identification of new thiosemicarbazide and thiazolidinone derivates in Toxoplasma gondii invasions
2018/31/N/NZ6/03004
Keywords:
thiosemicarbazide derivates thiazolidinone derivates Toxoplasma gondii molecular target
Descriptors:
- NZ6_6: Parasitology
- NZ6_8: Other related subjects
Panel:
NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology
Host institution :
Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska
woj. łódzkie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 16 - announced on 2018-09-14
Amount awarded: 139 900 PLN
Project start date (Y-m-d): 2019-10-01
Project end date (Y-m-d): 2022-09-30
Project duration:: 36 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Homogenizator ultradzwiękowy Sonopuls HD 2070.2.
- Oprogramowanie BioSolveIT, LeadIT rozszerzenie FlexX, 2 letnia licencja (8000 szt.) (8 000 PLN)
- Oprogramowanie GraphPad Prism (1000 szt.) (1 000 PLN)
Information in the final report
- Publication in academic press/journals (3)
- 1,3,4-Thiadiazoles effectively block invasion and proliferation of Toxoplasma gondiiAuthors:Lidia Węglińska; Adrian Bekier; Katarzyna Dzitko; Barbara Pacholczyk-Sienicka; Łukasz Albrecht; Tomasz Plech; Piotr Paneth, Agata PanethAcademic press:Cells (rok: 2021, tom: 10, strony: 1053), Wydawca: MDPIStatus:PublishedDOI:10.3390/cells10051053 - link to the publication
- 4-Arylthiosemicarbazide derivatives as toxoplasmic aromatic amino acid hydroxylase inhibitors and anti-inflammatory agentsAuthors:Adrian Bekier, Anna Brzostek, Agata Paneth, Bożena Dziadek, Jarosław Dziadek, Justyna Gatkowska, Katarzyna DzitkoAcademic press:International Journal of Molecular Science (rok: 2022, tom: 23(6), strony: 3213), Wydawca: MDPIStatus:PublishedDOI:10.3390/ijms23063213 - link to the publication
- 4-Arylthiosemicarbazide derivatives as a new class of tyrosinase inhibitors and anti-Toxoplasma gondii agentsAuthors:Adrian Bekiera, Lidia Węglińskab, Agata Panethb, Piotr Paneth and Katarzyna DzitkoAcademic press:Journal of Enzyme Inhibition and Medicinal Chemistry (rok: 2021, tom: 36, strony: 1145-1164), Wydawca: Taylor and Francis OnlineStatus:PublishedDOI:10.1080/14756366.2021.1931164 - link to the publication