Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Functional Characterization of Non-Collagenous Extracellular Matrix Proteins as a Potential Molecular Target and Novel Biomarker of Liver Fibrosis

2014/15/D/NZ5/03421

Keywords:

NASH steatosis chronic inflammation liver fibrosis ECM zebrafish transcriptomics hepatic stellate cells

Descriptors:

  • NZ4_4: Pathophysiology
  • NZ5_7: Human disease treatment
  • NZ2_2: Genomics, transcriptomics, epigenomics

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Michał Pawlak 

Number of co-investigators in the project: 1

Call: SONATA 8 - announced on 2014-09-15

Amount awarded: 541 875 PLN

Project start date (Y-m-d): 2015-09-02

Project end date (Y-m-d): 2019-03-01

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (1)
  1. Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin
    Authors:
    Philippe Lefebvre, Fanny Lalloyer, Eric Baugé, Michal Pawlak, Céline Gheeraert, Hélène Dehondt, Jonathan Vanhoutte, Eloise Woitrain, Nathalie Hennuyer, Claire Mazuy, Marie Bobowski-Gérard, Francesco Paolo Zummo, Bruno Derudas, Ann Driessen, Guy Hubens, Luisa Vonghia, Wilhelmus J. Kwanten, Peter Michielsen, Thomas Vanwolleghem, Jérôme Eeckhoute, An Verrijken, Luc Van Gaal, Sven Francque, and Bart Staels
    Academic press:
    JCI Insight (rok: 2017, tom: 2(13), strony: 45308), Wydawca: American Society for Clinical Investigation
    Status:
    Published
    DOI:
    10.1172/jci.insight.92264 - link to the publication
  2. PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD
    Authors:
    Barbara Gross, Michal Pawlak, Philippe Lefebvre, Bart Staels
    Academic press:
    Nature Reviews Endocrinology (rok: 2017, tom: 13, strony: 36–49), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/nrendo.2016.135 - link to the publication
  3. Dynamics of cardiomyocyte transcriptome and chromatin landscape demarcates key events of heart development.
    Authors:
    Pawlak M, Kedzierska KZ, Migdal M, Nahia KA, Ramilowski JA, Bugajski L, Hashimoto K, Marconi A, Piwocka K, Carninci P, Winata CL
    Academic press:
    Genome Research (rok: 2019, tom: 23(3), strony: 506-519), Wydawca: Cold Spring Harbor Laboratory Press
    Status:
    Published
    DOI:
    10.1101/gr.244491.118 - link to the publication
  4. Multi-omics analyses of early liver injury reveals cell-type-specific transcriptional and epigenomic shift
    Authors:
    Maciej Migdał, Eugeniusz Tralle, Karim Abu Nahia, Łukasz Bugajski, Katarzyna Zofia Kędzierska, Filip Garbicz , Katarzyna Piwocka, Cecilia Lanny Winata, Michał Pawlak
    Academic press:
    BMC Genomics (rok: 2021, tom: 22, strony: 904), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12864-021-08173-1 - link to the publication
  1. Fishing for novel targets of liver fibrosis by using danio rerio model
    Authors:
    Michal Pawlak, Katarzyna Kedzierska, Cecilia Winata
    Conference:
    LIVER FIBROSIS: THE NEXT GOAL OF TARGETED THERAPY? (rok: 2016, ), Wydawca: European Association for the Study of the Liver
    Data:
    konferencja 17-18 JUNE
    Status:
    Published

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