Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Functional Characterization of Non-Collagenous Extracellular Matrix Proteins as a Potential Molecular Target and Novel Biomarker of Liver Fibrosis

2014/15/D/NZ5/03421

Keywords:

NASH steatosis chronic inflammation liver fibrosis ECM zebrafish transcriptomics hepatic stellate cells

Descriptors:

  • NZ4_4:
  • NZ5_7:
  • NZ2_2:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Michał Andrzej Pawlak 

Number of co-investigators in the project: 1

Call: SONATA 8 - announced on 2014-09-15

Amount awarded: 541 875 PLN

Project start date (Y-m-d): 2015-09-02

Project end date (Y-m-d): 2019-03-01

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (1)
  1. Multi-omics analyses of early liver injury reveals cell-type-specific transcriptional and epigenomic shift
    Authors:
    Maciej Migdał, Eugeniusz Tralle, Karim Abu Nahia, Łukasz Bugajski, Katarzyna Zofia Kędzierska, Filip Garbicz , Katarzyna Piwocka, Cecilia Lanny Winata, Michał Pawlak
    Academic press:
    BMC Genomics (rok: 2021, tom: 22, strony: 904), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12864-021-08173-1 - link to the publication
  2. PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD
    Authors:
    Barbara Gross, Michal Pawlak, Philippe Lefebvre, Bart Staels
    Academic press:
    Nature Reviews Endocrinology (rok: 2017, tom: 13, strony: 36–49), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/nrendo.2016.135 - link to the publication
  3. Dynamics of cardiomyocyte transcriptome and chromatin landscape demarcates key events of heart development.
    Authors:
    Pawlak M, Kedzierska KZ, Migdal M, Nahia KA, Ramilowski JA, Bugajski L, Hashimoto K, Marconi A, Piwocka K, Carninci P, Winata CL
    Academic press:
    Genome Research (rok: 2019, tom: 23(3), strony: 506-519), Wydawca: Cold Spring Harbor Laboratory Press
    Status:
    Published
    DOI:
    10.1101/gr.244491.118 - link to the publication
  1. Fishing for novel targets of liver fibrosis by using danio rerio model
    Authors:
    Michal Pawlak, Katarzyna Kedzierska, Cecilia Winata
    Conference:
    LIVER FIBROSIS: THE NEXT GOAL OF TARGETED THERAPY? (rok: 2016, ), Wydawca: European Association for the Study of the Liver
    Data:
    konferencja 17-18 JUNE
    Status:
    Published

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