Projects funded by the NCN

"Integrated Fixed-Dose Combination Drugs in Depression Therapy: A New Standard of Treatment and Mechanism of Action Stud...

Call: OPUS 28 , Panel: NZ7

Principal investigator: prof. Gabriel Piotr Nowak

Instytut Farmakologii PAN

Optogenetic and chemogenetic identification of brain circuits and cellular mechanisms underlying antidepressants resista...

Call: OPUS 26 , Panel: NZ7

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii PAN

Translational and interdisciplinary investigation of phenotypes of reinforcement sensitivity as predictors of the respon...

Call: OPUS 22 , Panel: HS6

Principal investigator: dr hab. Rafał Ryguła

Instytut Farmakologii PAN

The role of the immune checkpoints in the pathomechanism of depressive disorders.

Call: OPUS 22 , Panel: NZ6

Principal investigator: prof. Marta Wanda Kubera

Instytut Farmakologii PAN

Prenatal exposure to glucocorticoids as a risk factor for depression - the importance of epigenetic mechanisms in the br...

Call: SONATA 16 , Panel: NZ7

Principal investigator: dr Katarzyna Elżbieta Głombik

Instytut Farmakologii PAN

The influence of microplastics on the toxicity and fate of selected antidepressants

Call: OPUS 18 , Panel: NZ8

Principal investigator: prof. Grzegorz Leszek Nałęcz-Jawecki

Warszawski Uniwersytet Medyczny

Novel pharmacological strategies for the treatment of depression

Call: OPUS 16 , Panel: NZ7

Principal investigator: dr hab. Katarzyna Młyniec

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Pharmacological and optogenetic investigation of the mechanism of action of Deep Brain Stimulation of the ventromedial p...

Call: OPUS 13 , Panel: NZ7

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii PAN

Zinc Deficiency: An essential Variable for the Induction od Resistance to Antidepressants

Call: PRELUDIUM 13 , Panel: NZ5

Principal investigator: dr Anna Maria Rafało-Ulińska

Instytut Farmakologii PAN

Role of oxidative stress and ceramide in the pathogenesis of depression and in the mechanizm of action of antidepressant...

Call: PRELUDIUM 12 , Panel: NZ5

Principal investigator: Justyna Józefa Brodowicz

Instytut Farmakologii PAN

Evaluation of interactions of aripiprazole, the atypical amtipsychotic drug, with the selected antidepressants in the ra...

Call: OPUS 12 , Panel: NZ7

Principal investigator: dr hab. Zofia Maria Rogóż

Instytut Farmakologii PAN

Modeling of quantitative structure-metabolic stability relationships as a tool to improve design of potential novel anti...

Call: OPUS 12 , Panel: NZ7

Principal investigator: prof. Tomasz Bączek

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

The importance of interaction between NMDA and AMPA receptors and scaffolding proteins in the excitatory synaptic in the...

Call: OPUS 11 , Panel: NZ7

Principal investigator: dr hab. Magdalena Jolanta Sowa-Kućma

Uniwersytet Rzeszowski, Kolegium Nauk Medycznych

The effect of the metabotropic glutamatergic receptor ligands on potentiating the antidepressant-like actvity of scopola...

Call: PRELUDIUM 10 , Panel: NZ7

Principal investigator: Karolina Sylwia Podkowa

Instytut Farmakologii PAN

The role of inflammation, oxidative and nitrosative stress, tryptophan catabolites pathway and DNA base excision repair ...

Call: OPUS 10 , Panel: NZ7

Principal investigator: dr hab. Tomasz Śliwiński

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Functional dissection of three alpha(1)-adrenergic receptor subtypes in the effects of antidepressant drugs: exploitatio...

Call: OPUS 9 , Panel: NZ7

Principal investigator: prof. Irena Maria Nalepa

Instytut Farmakologii PAN

Investigation of the effects and mechanisms of action of Deep Brain Stimulation in two animal models of treatment-resist...

Call: OPUS 9 , Panel: NZ7

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii PAN

The application of a modern chromatographic platform with biodetection: HPLC-DAD/MAO A/ESI-TOF-MS in the antidepressant ...

Call: SONATA 9 , Panel: NZ7

Principal investigator: dr hab. Wirginia Anna Kukuła-Koch

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

Molecular mechanism of action of antidepressant drugs in the in vitro model of contact allergy in the human cell line Ha...

Call: PRELUDIUM 7 , Panel: NZ6

Principal investigator: Katarzyna Curzytek

Instytut Farmakologii PAN

Evaluation of the role of transcription factor CREB in the mechanisms antidepressant treatment: study on the novel genet...

Call: OPUS 7 , Panel: NZ7

Principal investigator: dr Grzegorz Kreiner

Instytut Farmakologii PAN

Research of mechanisms of antidepressant action of group II and III mGlu receptor ligands and their role in inducing rap...

Call: OPUS 7 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Pałucha-Poniewiera

Instytut Farmakologii PAN

Synthesis of pyridopyrimidine derivatives, dual affinity ligands for 5-HT1AR and SERT.

Call: OPUS 6 , Panel: NZ7

Principal investigator: prof. Franciszek Herold

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Antidepressats as substances that increase the activity of risperidone, an atypical antipsychotic drug in animal models

Call: PRELUDIUM 5 , Panel: NZ7

Principal investigator: Katarzyna Karolina Kamińska

Instytut Farmakologii PAN

The role of chemokines in the pathogenesis of depression and molecular mechanism of action of antidepressants.

Call: OPUS 5 , Panel: NZ7

Principal investigator: prof. Agnieszka Basta-Kaim

Instytut Farmakologii PAN

Transcription factor MeCP2 as an intracellular object of study on the mechanism of depression and as a potential pharmac...

Call: SONATA 5 , Panel: NZ7

Principal investigator: dr Magdalena Jolanta Sowa-Kućma

Instytut Farmakologii PAN

Research on influence of antidepressant drugs on serum and brain levels of neurotrophins in rats, affected by the time d...

Call: OPUS 4 , Panel: NZ4

Principal investigator: dr Maciej Sławomir Kuśmider

Instytut Farmakologii PAN

The role of CRH-BP protein in the regulation of the hypothalamic-pituitary-adrenal axis after antidepressant drugs treat...

Call: OPUS 3 , Panel: NZ4

Principal investigator: dr Joanna Solich

Instytut Farmakologii PAN

Role of the endocannabionoid system in the pathogenesis of depression and in the mechanism of action of antidepressant d...

Call: OPUS 3 , Panel: NZ7

Principal investigator: prof. Małgorzata Maria Filip

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Evaluation of the role of subpopulations of T lymphocytes (Treg: CD4+CD25+, CD4+CD25- i Teff: Th2) in depression using p...

Call: OPUS 3 , Panel: NZ4

Principal investigator: dr Sylwia Kędracka-Krok

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

The role of GPR39 receptor in the mechanism of antidepressant action

Call: OPUS 2 , Panel: NZ7

Principal investigator: dr Katarzyna Młyniec

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Metabolic stability and inhibition of P450 enzymes in combination with chemometric techniques as a tool for selection of...

Call: OPUS 2 , Panel: NZ1

Principal investigator: prof. Tomasz Bączek

Gdański Uniwersytet Medyczny, Wydział Farmcautyczny z Oddziałem Medycyny Laboratoryjnej