Synthesis of pyridopyrimidine derivatives, dual affinity ligands for 5-HT1AR and

Synthesis of pyridopyrimidine derivatives, dual affinity ligands for 5-HT1AR and SERT.

2013/11/B/NZ7/01638

Keywords

Descriptors

NZ7_14: Farmacja, farmakoterapia, farmakologia
ST5_16: Chemia biologiczna

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Franciszek Herold

Number of co-investigators in the project: 10

Call

OPUS 6 – announced on 2013-09-16

Amount awarded: 501 660 PLN
Project start date: 2014-08-07
Project end date: 2018-08-06
Project duration: 48 months (the same as in the proposal)
Project status: Project settled

Equipment purchased [PL]

Aparat do oznaczania temperatur topnienia Electrothermal.
Mieszadło magnetyczne z czujnikiem temperatury (2 pcs). Cost: 8 000 PLN
Oprogramowanie Gaussian. Cost: 30 000 PLN
Wyparka próżniowa rotacyjna z membranową pompą próżniową. Cost: 37 000 PLN

Information in the final report

Publication in academic press/journals (2)

Synthesis of new 5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT1A receptor ligands

Authors:
Grzegorz Ślifirski, Marek Król, Jerzy Kleps, Piotr Podsadni, Mariusz Belka, Tomasz Bączek, Agata Siwek, Katarzyna Stachowicz, Bernadeta Szewczyk, Gabriel Nowak, Andrzej Bojarski, Anna E. Kozioł, Jadwiga Turło, Franciszek Herold

Academic press:
European Journal of Medicinal Chemistry (year: 2019, volume: 180, pages: 383-397), Publisher: Elsevier

Status:
Published

DOI:
10.1016/j.emech.2019.07.027 – link to the publication
Synthesis of novel pyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT1A receptor ligands

Authors:
Grzegorz Ślifirski; Marek Król, Ph.D.; Jerzy Kleps; Szymon Ulenberg; Mariusz Belka; Tomasz Bączek; Agata Siwek; Katarzyna Stachowicz; Bernadeta Szewczyk; Gabriel Nowak; Andrzej Bojarski; Anna E Kozioł; Jadwiga Turło; Franciszek Herold

Academic press:
European Journal of Medicinal Chemistry (year: 2019, volume: 166, pages: 144-158), Publisher: Elsevier

Status:
Published

DOI:
10.1016/j.ejmech.2019.01.031 – link to the publication

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