Search results

1. 5-Hydroxymethylcytosine (sixth DNA base) and its putative derivative - 5-hydroxymethyluracil as a new cancer biomarkers?…

Principal investigator: prof. Ryszard Oliński

Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy; Wydział Farmaceutyczny

Call: OPUS 5, Panel: NZ5

2. Studies on a new method for the synthesis of oligoribonucleotides modified with 5-aminomethyluridines (xnm5U) and 5-amin…

Principal investigator: Karolina Bartosik

Politechnika Łódzka, Wydział Chemiczny

Call: PRELUDIUM 9, Panel: ST5

3. Influence of (5'R) and (5'S) 5',8-cyclo-2'-deoxypurines on clustered DNA lesions repair

Principal investigator: dr hab. Bolesław Tomasz Karwowski

Uniwersytet Medyczny w Łodzi, Wydział Farmaceutyczny

Call: OPUS 12, Panel: NZ7

4. Structural Dynamics and Operando Analysis of Nanostructured Oxide Electrodes for Photoelectrochemical Conversion of 5-Hy…

Principal investigator: dr Marta Ewa Michalska-Domańska

Wojskowa Akademia Techniczna im. Jarosława Dąbrowskiego

Call: OPUS 28 (LAP), Panel: ST5

5. Dual Se-containing 5-HT1A and 5-HT7 biased agonists activating sigma-1 receptor as a hope of finding fast-acting antidep…

Principal investigator: prof. Karolina Anna Pytka

Uniwersytet Jagielloński

Call: OPUS 27, Panel: NZ7

6. The role of codependent 5-HT1a and 5-HT7 receptor signalling in the hippocampal stress response

Principal investigator: Marcin Siwiec

Instytut Farmakologii PAN

Call: PRELUDIUM 12, Panel: NZ4

7. Biased inverse agonists of 5-HT6 receptor and dual 5-HT6/MAO-B inhibitors - in search for new therapeutic approaches for…

Principal investigator: prof. Paweł Maria Zajdel

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: OPUS 11, Panel: NZ7

8. Thymol-derived 1,3,5-triazines, the non-indole and non-sulfone 5-HT6 receptor ligands, as a starter in search for an inn…

Principal investigator: prof. Jadwiga Handzlik

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: OPUS 16, Panel: NZ7

9. Adenosine 5'-phosphoramidate as a novel signaling molecule; Study of enzymatic synthesis of this nucleotide and analysis…

Principal investigator: prof. Andrzej Bolesław Guranowski

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa i Bioinżynierii

Call: OPUS 3, Panel: NZ1

10. New nucleotide analogs containing triazole within oligophosphate bridge as mimics of the 5' end of mRNA - synthesis, pro…

Principal investigator: Sylwia Ciechanowicz

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Call: PRELUDIUM 9, Panel: ST5

11. Transformation of 5'-O-monothiophosphate nucleoside to 5'-O-monophosphate in the cell - possible metabolism of phosphoro…

Principal investigator: dr Agnieszka Krakowiak

Centrum Badań Molekularnych i Makromolekularnych PAN

Call: OPUS 5, Panel: ST5

12. Dual 5-HT3 receptor/5-HT6 receptor antagonists in neuropsychiatric and neurological disorders

Principal investigator: prof. Paweł Maria Zajdel

Uniwersytet Jagielloński, Collegium Medicum

Call: OPUS 22, Panel: NZ7

13. Dual-acting 5-HT6/5-HT7 receptor antagonists: exploring beneficial effects for the treatment of neurodegenerative disord…

Principal investigator: Michał Kamiński

Uniwersytet Jagielloński

Call: PRELUDIUM 24, Panel: NZ7

14. Mechanisms of Antidepressant Action of Psilocybin: The Role of 5-HT2B-5-HT1A Receptor Dimerization and GSK-3β Activation…

Principal investigator: dr hab. Agata Faron-Górecka

Instytut Farmakologii PAN

Call: OPUS 27, Panel: NZ7

15. Targeting the serotonin 5-HT7 receptor in a search for new strategies of mental disorders treatment

Principal investigator: Patryk Pyka

Uniwersytet Jagielloński, Collegium Medicum

Call: PRELUDIUM 22, Panel: NZ7

16. Investigation of molecular mechanisms of rapid antidepressant action of NLX-101, a biased agonist of the 5-HT1A receptor…

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii PAN

Call: OPUS 18, Panel: NZ7

17. Development of unique molecular probes: low-basicity agonists for the study of 5-HT7 receptor function

Principal investigator: prof. Andrzej Jacek Bojarski

Instytut Farmakologii PAN

Call: OPUS 13, Panel: NZ7

18. 5-HT6 receptor ligands as addition to antipsychotic therapy in schizophrenia - an impact on body weight, metabolic param…

Principal investigator: prof. Anna Małgorzata Wesołowska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: OPUS 10, Panel: NZ7

19. Traizine 5-HT6 receptor ligands - new perspective for therapy of current civilization CNS-diseases

Principal investigator: dr hab. Jadwiga Handzlik

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: OPUS 9, Panel: NZ7

20. Design and Pharmacological Evaluation of Marine Alkaloid-Inspired 5-HT2A Receptor Ligands

Principal investigator: Szymon Kazimierz Kordylewski

Instytut Farmakologii PAN

Call: PRELUDIUM 24, Panel: NZ1

21. Modulation of 5-HT7 receptor signaling as common mechanism involved in the long-lasting antidepressant effects of typica…

Principal investigator: dr Barbara Wanda Chruścicka-Smaga

Instytut Farmakologii PAN

Call: SONATA 20, Panel: NZ7

22. First-in-class dual modulators of necroptosis kinases and 5-HT6 receptors as an innovative approach to develop an effect…

Principal investigator: prof. Jadwiga Handzlik

Uniwersytet Jagielloński, Collegium Medicum

Call: OPUS 26, Panel: NZ7

23. The cross-talk between 5-HTR2A and mGluR2 as a window for antidepressant effects of psilocybin.

Principal investigator: prof. Andrzej Mikołaj Pilc

Instytut Farmakologii PAN

Call: OPUS 25, Panel: NZ7

24. Combination of FAAH inhibition with action via serotonin 5-HT6 receptor as pioneering approach to fight with Alzheimer D…

Principal investigator: Kinga Maria Czarnota-Łydka

Uniwersytet Jagielloński, Collegium Medicum

Call: PRELUDIUM 21, Panel: NZ7

25. Liposomal nanoformulations of cannabidiol with celecoxib or 2,5-dimethylcelecoxib as a novel treatment option for gliobl…

Principal investigator: dr hab. Violetta Katarzyna Krajka-Kuźniak

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Call: PRELUDIUM BIS 3, Panel: NZ5

26. The role of 5-methylcytosine RNA methyltransferases in the regulation of cancer cell responses to extracellular and exog…

Principal investigator: dr hab. Anna Karolina Lewińska

Uniwersytet Rzeszowski, Collegium Medicum Wydział Biotechnologii

Call: OPUS 22, Panel: NZ2

27. Molecular mechanisms of 5-HT7R-mediated resilience in stress-related disorders

Principal investigator: prof. Jakub Mateusz Włodarczyk

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Call: OPUS 21, Panel: NZ4

28. The role of vitamin D receptor in 5-fluorouracil responsiveness of colorectal cancer cells

Principal investigator: dr Magdalena - Milczarek

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Call: SONATA 16, Panel: NZ5

29. The role of 5-hydroxymethyluracil in chronic lymphocytic leukemia development

Principal investigator: dr hab. Daniel Stefan Gackowski

Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Wydział Farmaceutyczny

Call: PRELUDIUM BIS 2, Panel: NZ5

30. New 5-HT6 receptor ligands from the group of sulfonamide derivatives of cyclic arylguanidines in the treatment of gliobl…

Principal investigator: dr Przemysław Patryk Zaręba

Politechnika Krakowska im. Tadeusza Kościuszki, Wydział Inżynierii i Technologii Chemicznej

Call: PRELUDIUM 19, Panel: NZ7

31. Towards innovative strategy for treatment of Alzheimer's Disease via dual inhibition of receptor 5-HT6 and kinase CDK5.

Principal investigator: Sylwia Sudoł-Tałaj

Uniwersytet Jagielloński, Collegium Medicum

Call: PRELUDIUM 19, Panel: NZ7

32. The place does matter - 5-HT7R-mediated structural plasticity in the specific hippocampal subregions

Principal investigator: dr Monika Bijata

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Call: SONATA 15, Panel: NZ4

33. mRNA 5' end methylation status: towards deeper understanding of biological role and identification of synthetic mimics

Principal investigator: prof. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Call: OPUS 17, Panel: ST4

34. Neuroprotective properties of 5-HT6 receptor ligands in the group of 2-arylpyrrole derivatives – a new insight into neur…

Principal investigator: Marcin Józef Drop

Uniwersytet Jagielloński, Collegium Medicum

Call: PRELUDIUM 17, Panel: NZ7

35. Therapeutic potential of biased 5-HT7 receptor ligands in the treatment of depression

Principal investigator: prof. Paweł Maria Zajdel

Uniwersytet Jagielloński, Collegium Medicum

Call: OPUS 17, Panel: NZ7

36. Defining roles of LINE-1 mRNA 5' and 3' ends in the retrotransposon biology

Principal investigator: dr hab. Zbigniew Warkocki

Instytut Chemii Bioorganicznej PAN

Call: OPUS 17, Panel: NZ1

37. The influence of muscarinic acetylcholine receptors (M1, M4 and M5) and serotonergic 5-HT1A receptor modulation on cogni…

Principal investigator: dr Paulina Agnieszka Cieślik

Instytut Farmakologii PAN

Call: PRELUDIUM 16, Panel: NZ7

38. 5-Hydroxylmethyluracil as a potential specific biomarker of leukemic cells in chronic lymphocytic leukemia

Principal investigator: Anna Łabejszo

Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

Call: PRELUDIUM 15, Panel: NZ5

39. NAD+ non-canonical 5' RNA cap in Arabidopsis thaliana: metabolism, cellular functions and physiological impact

Principal investigator: prof. Joanna Kufel

Uniwersytet Warszawski, Wydział Biologii

Call: OPUS 15, Panel: NZ3

40. New hybrid compounds derived from 2-(2,5-dioxopyrrolidin-1-yl)-propanamide in the search for substances effective in tre…

Principal investigator: Michał Andrzej Abram

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: PRELUDIUM 15, Panel: NZ7

41. Molecular mechanism of action and therapeutic effect of 5-aza-2'-deoxycytidine and topoisomerase inhibitors combination …

Principal investigator: dr hab. Wojciech Kałas

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Call: OPUS 13, Panel: NZ5

42. Novel hybrid compounds derived from pyrrolidine-2,5-dione or imidazolidine-2,4-dione scaffold and their effect on centra…

Principal investigator: dr hab. Krzysztof Tomasz Kamiński

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: OPUS 13, Panel: NZ7

43. Investigating the biological role of 5' nucleotidases cN-IIIA and cN-IIIB in mRNA degradation and their terapeutic signi…

Principal investigator: dr Dorota Maria Kubacka

Uniwersytet Warszawski, Wydział Fizyki

Call: SONATINA 1, Panel: NZ1

44. Novel multi-target directed ligands combining cholinesterase inhibition and 5-HT6 antagonism - design, synthesis and pha…

Principal investigator: dr hab. Anna Karolina Więckowska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: SONATA 12, Panel: NZ7

45. Polymorphisms of miRNA genes and in the 3'UTR region of the ADME genes in breast cancer patients treated with FAC (5-flu…

Principal investigator: dr Jolanta Ewa Pamuła-Piłat

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie

Call: SONATA 11, Panel: NZ5

46. Modulation of amygdala neural network activity by the 5-HT7 receptor

Principal investigator: prof. Krzysztof Tokarski

Instytut Farmakologii PAN

Call: OPUS 11, Panel: NZ4

47. Search for the functionally selective 5-HT1A receptor agonists as new pharmacological tools in the development of treatm…

Principal investigator: prof. Marcin Roman Kołaczkowski

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: OPUS 10, Panel: NZ7

48. The search for new substances with anticonvulsant and antinociceptive activity among hybrid compounds based on the pyrro…

Principal investigator: dr hab. Krzysztof Tomasz Kamiński

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: SONATA BIS 5, Panel: NZ7

49. Searching for the new lead structures for 5-HT7 serotonin receptor ligands with increased metabolic stability.

Principal investigator: Sabina Marta Podlewska

Instytut Farmakologii PAN

Call: HARMONIA 7, Panel: NZ7

50. Changes in neurogenesis during withdrawal from nicotine self-administration in rats - role of serotonin (5-HT)2C recepto…

Principal investigator: dr Magdalena Joanna Zaniewska

Instytut Farmakologii PAN

Call: OPUS 9, Panel: NZ4

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