The role of 5-methylcytosine RNA methyltransferases in the regulation of cancer cell responses to extracellular and exogenous RNA
2021/43/B/NZ2/02210
Keywords
Descriptors
- NZ2_001: Genetyka molekularna
Panel
NZ2 – Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology
Host institution
Uniwersytet Rzeszowski, Collegium Medicum Wydział Biotechnologii
Voivodeship: podkarpackie
Principal investigator (from the host institution)
dr hab. Anna Karolina Lewińska
Number of co-investigators in the project: 5
Call
OPUS 22 – announced on 2021-09-15
- Amount awarded
- 1 629 200 PLN
- Project start date
- 2022-07-07
- Project end date
- 2027-07-06
- Project duration
- 60 months (the same as in the proposal)
- Project status
- Pending project
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (3)
-
TRDMT1 methyltransferase gene knockout attenuates STING-based cell death signaling during self-extracellular RNA-mediated response in drug-induced senescent osteosarcoma cells
- Authors:
- Gabriela Betlej, Anna Deręgowska, Maciej Wnuk, Dominika Błoniarz, Tomasz Szmatoła, Katarzyna Klimczak, Jagoda Adamczyk-Grochala, Julia Świętoń, Anna Lewińska.
- Academic press:
- Cellular and Molecular Life Sciences (year: 2025, volume: 82, pages: 310), Publisher: Springer Nature
- Status:
- Published
- DOI:
- 10.1007/s00018-025-05835-1 – link to the publication
-
TRDMT1-mediated RNA C-5 methylation as a novel target in anticancer therapy
- Authors:
- Anna Lewińska, Jagoda Adamczyk-Grochala, Maciej Wnuk.
- Academic press:
- Biochimica et Biophysica Acta (BBA) - Reviews on Cancer (year: 2023, volume: 1878(6), pages: 188964), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.bbcan.2023.188964 – link to the publication
-
Non-targeting siRNA-mediated responses are associated with apoptosis in chemotherapy-induced senescent skin cancer cells
- Authors:
- Gabriela Betlej, Dominika Błoniarz, Anna Lewińska, Maciej Wnuk.
- Academic press:
- Chemico-Biological Interactions (year: 2023, volume: 369, pages: 110254), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.cbi.2022.110254 – link to the publication