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The role of 5-methylcytosine RNA methyltransferases in the regulation of cancer cell responses to extracellular and exogenous RNA

2021/43/B/NZ2/02210

Keywords:

5-methylcytosine RNA methyltransferases extracellular and exogenous RNA proinflammatory response cancer cells genetic instability

Descriptors:

  • NZ2_001:

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Rzeszowski, Collegium Medicum Wydział Biotechnologii

woj. podkarpackie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Anna Karolina Lewińska 

Number of co-investigators in the project: 5

Call: OPUS 22 - announced on 2021-09-15

Amount awarded: 1 629 200 PLN

Project start date (Y-m-d): 2022-07-07

Project end date (Y-m-d): 2026-07-06

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Non-targeting siRNA-mediated responses are associated with apoptosis in chemotherapy-induced senescent skin cancer cells
    Authors:
    Gabriela Betlej, Dominika Błoniarz, Anna Lewińska, Maciej Wnuk.
    Academic press:
    Chemico-Biological Interactions (rok: 2023, tom: 369, strony: 110254), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cbi.2022.110254 - link to the publication
  2. Non-targeting siRNA-mediated responses are associated with apoptosis in chemotherapy-induced senescent skin cancer cells
    Authors:
    Gabriela Betlej, Dominika Błoniarz, Anna Lewińska, Maciej Wnuk.
    Academic press:
    Chemico-Biological Interactions (rok: 2023, tom: 369, strony: 110254), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cbi.2022.110254 - link to the publication
  3. TRDMT1-mediated RNA C-5 methylation as a novel target in anticancer therapy
    Authors:
    Anna Lewińska, Jagoda Adamczyk-Grochala, Maciej Wnuk.
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Reviews on Cancer (rok: 2023, tom: 1878(6), strony: 188964), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbcan.2023.188964 - link to the publication

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