Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Novel hybrid compounds derived from pyrrolidine-2,5-dione or imidazolidine-2,4-dione scaffold and their effect on central nervous system activity.

2017/25/B/NZ7/01048

Keywords:

pyrrolidine-2,5-dione imidazolidine-2,4-dione epilepsy neuropathic pain depression anxiety

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • ST5_16:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Krzysztof Kamiński 

Number of co-investigators in the project: 12

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 575 200 PLN

Project start date (Y-m-d): 2018-01-03

Project end date (Y-m-d): 2023-01-02

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Wyparka rotacyjna z łaźnią, pompa próżniowa, termostat cyrkulacyjny (chiller) (54 000 PLN)
  2. chłodnica.
  3. Vortex 3 - wytrząsarka.
  4. Wyparka rotacyjna Hei-VAP (20 725 PLN)
  5. mieszadło magnetyczne z grzaniem.
  6. nakładki grzewcze na mieszadło magnetyczne.
  7. mini termostat cyrkulacyjny (chiller) (13 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (6)
  1. Synthesis, anticonvulsant and antinociceptive activity of new hybrid compounds: Derivatives of 3-(3-methylthiophen-2-yl)-pyrrolidine-2,5-dione
    Authors:
    Małgorzata Góra, Anna Czopek, Anna Rapacz, Anna Dziubina, Monika Głuch-Lutwin, Barbara Mordyl, Jolanta Obniska
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 5750), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21165750 - link to the publication
  2. Synthesis, anticonvulsant, and antinociceptive activity of new 3-(2-chlorophenyl)- and 3-(3-chlorophenyl)-2,5-dioxo-pyrrolidin-1-yl-acetamides
    Authors:
    Góra Małgorzata, Czopek Anna, Rapacz Anna, Gębska Anna, Wójcik-Pszczoła Katarzyna, Pękala Elżbieta, Kamiński Krzysztof
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 1564), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26061564 - link to the publication
  3. Antinociceptive and Antiallodynic Activity of Some 3-(3-Methylthiophen-2-yl)pyrrolidine-2,5-dione Derivatives in Mouse Models of Tonic and Neuropathic Pain
    Authors:
    Dziubina, A.; Rapacz, A.; Czopek, A.; Góra, M.; Obniska, J; Kamiński, K.
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 4057), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23074057 - link to the publication
  4. Design, synthesis and biological activity of new amides derived from 3-benzhydryl and 3-sec-butyl-2,5-dioxo-pyrrolidin-1-yl-acetic acid
    Authors:
    Góra Małgorzata, Czopek Anna, Rapacz Anna, Giza Agnieszka, Koczurkiewicz-Adamczyk Paulina, Pękala Elżbieta, Obniska Jolanta, Kamiński Krzysztof
    Academic press:
    ChemMedChem (rok: 2021, tom: 16, strony: 1619-1630), Wydawca: Wiley-VCHGmbH
    Status:
    Published
    DOI:
    10.1002/cmdc.202001007 - link to the publication
  5. Synthesis and pharmacological evaluation of novel N-Mannich bases derived from 5,5-diphenyl and 5,5-di(propan-2-yl)imidazolidine-2,4-dione core.
    Authors:
    Czopek A, Byrtus H, Zagórska A, Rychtyk J, Góra M, Sałat K, Rapacz A, Obniska J
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2019, tom: 29(16), strony: 2387-2392), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2019.06.001 - link to the publication
  1. NEW HYBRID COMPOUNDS, DERIVETIVES OF 3-(3- METHYLTHIOPHEN-2-YL) AND (BENZO[B]THIOPHEN-2-YL)- PYRROLIDINE-2,5-DIONE WITH POTENTIAL ANTICONVULSANT ACTIVITY
    Authors:
    J Obniska, M Góra, A Czopek, A Rapacz
    Conference:
    Joint Meeting on Medicinal Chemistry (rok: 2019, ), Wydawca: European Federation for Medicinal Chemistry
    Data:
    konferencja 2019-06-27-30
    Status:
    Published
  2. NOWE HYBRYDOWE POCHODNE 3-(3-METYLOTIOFEN-2-YLO) I (BENZO[B]TIOFEN-2-YLO)-PIROLIDYNO-2,5-DIONU O POTENACJALNEJ AKTYWNOŚCI PRZECIWDRGAWKOWEJ
    Authors:
    Jolanta Obniska, Małgorzata Góra, Anna Czopek, Anna Rapacz
    Conference:
    IV SYMPOZJUM "SZKOŁA CHEMII MEDYCZNEJ" (rok: 2019, ), Wydawca: Uniwersytet Medyczny im Piastów Śląskich we Wrocławiu
    Data:
    konferencja 2019-09-25-27
    Status:
    Published
  3. SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NOVEL 5-(3-METHYLTHIOPHEN-2-YL)IMIDAZOLIDINE-2,4-DIONE DERIVATIVES
    Authors:
    Anna Czopek, Grzegorz Satała, Andrzej J. Bojarski, Krzysztof Kamiński
    Conference:
    18 Hellenic Symposium on Medicinal Chemistry (rok: 2021, ), Wydawca: HELLENIC SOCIETY OF MEDICINAL CHEMISTRY
    Data:
    konferencja 25-27.02.
    Status:
    Published
  4. SYNTHESIS AND PHYSICOCHEMICAL PROPERTIES OF NEW DERIVETIVES OF 3-(3-METHYL-THIOPHEN-2-YL)-PYRROLIDINE-2,5-DIONE WITH POTENTIAL ANTICONVULSANT ACTIVITY
    Authors:
    Jolanta Obniska, Małgorzata Góra, Anna Czopek, Krzysztof Kamiński, Anna Rapacz
    Conference:
    International Symposium on Medicinal Chemistry (rok: 2018, ), Wydawca: EFMC European Federation for Medicinal Chemistry
    Data:
    konferencja 2-6 September
    Status:
    Published
  5. Pharmacological Profile and Cytotoxic Evaluation of Novel 5-(3-Methylthiophen-2yl)hydantoin Derivatives with Arylpiperazinylalkyl Moiety
    Authors:
    Anna Czopek, Agnieszka Zagórska, Katarzyna Wójcik-Pszczoła, Elżbieta Pękala, Grzegorz Satała, Andrzej J. Bojarski, Jolanta Obniska, Krzysztof Kamiński
    Conference:
    X Konwersatorium Chemii Medycznej (rok: 2021, ), Wydawca: Uniwersytet Medyczny w Lublinie
    Data:
    konferencja 3-5.09.2021
    Status:
    Published
  6. Synthesis and anticonvulsant activity of new hybrid compounds derived from 5,5-disubstituted or 5-spiro-imidazolidine-2,4-dione core and morpholine moiety
    Authors:
    JM Obniska, A. Czopek, H. Byrtus, M. Góra, K. Kamiński, A. Rapacz
    Conference:
    Fourteenth EILAT Conference on New Antiepileptic Drugs and Devices (EILAT XIV) (rok: 2018, ), Wydawca: The Hebrew University of Jerusalem, Israel
    Data:
    konferencja 13-16 Maj
    Status:
    Published

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