mRNA 5' end methylation status: towards deeper understanding of biological role and identification of synthetic mimics
2019/33/B/ST4/01843
Keywords
Descriptors
- ST4_009: Chemia biologiczna
- ST4_010: Chemia polimerów, biopolimerów
- NZ1_002: Biochemia
Panel
ST4 – Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development
Host institution
Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego
Voivodeship: mazowieckie
Principal investigator (from the host institution)
Number of co-investigators in the project: 6
Call
OPUS 17 – announced on 2019-03-15
- Amount awarded
- 1 995 440 PLN
- Project start date
- 2020-02-20
- Project end date
- 2024-02-19
- Project duration
- 48 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (9)
-
Chemically Modified Poly(A) Analogs Targeting PABP: Structure Activity Relationship and Translation Inhibitory Properties
- Authors:
- Olga Perzanowska, Miroslaw Smietanski, Jacek Jemielity, Joanna Kowalska
- Academic press:
- Chemistry—A European Journal (year: 2022, volume: 28 (42), pages: e202201115), Publisher: Wiley-VCH GmbH
- Status:
- Published
- DOI:
- 10.1002/chem.202201115 – link to the publication
-
Quick Access to Nucleobase-Modified Phosphoramidites for the Synthesis of Oligoribonucleotides Containing Post-Transcriptional Modifications and Epitranscriptomic Marks
- Authors:
- Kamil Ziemkiewicz, Marcin Warminski, Radoslaw Wojcik, Joanna Kowalska, Jacek Jemielity
- Academic press:
- The Journal of Organic Chemistry (year: 2022, volume: 87 (15), pages: 10333-10348), Publisher: American Chemical Society
- Status:
- Published
- DOI:
- 10.1021/acs.joc.2c01390 – link to the publication
-
2′-O-Methylation of the second transcribed nucleotide within the mRNA 5′ cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasion
- Authors:
- Karolina Drazkowska, Rafal Tomecki, Marcin Warminski, Natalia Baran, Dominik Cysewski, Anaïs Depaix, Renata Kasprzyk, Joanna Kowalska, Jacek Jemielity, Pawel J. Sikorski
- Academic press:
- Nucleic Acids Research (year: 2022, volume: 50(16), pages: 9051–9071), Publisher: Oxford University Press
- Status:
- Published
- DOI:
- 10.1093/nar/gkac722 – link to the publication
-
Preparation of RNAs with non-canonical 5′ ends using novel di- and trinucleotide reagents for co-transcriptional capping
- Authors:
- Anaïs Depaix, Ewa Grudzien-Nogalska, Bartlomiej Fedorczyk, Megerditch Kiledjian, Jacek Jemielity, Joanna Kowalska
- Academic press:
- FRONTIERS IN MOLECULAR BIOSCIENCES (year: 2022, volume: 9, pages: Article Number 854170), Publisher: FRONTIERS MEDIA SA
- Status:
- Published
- DOI:
- 10.3389/fmolb.2022.854170 – link to the publication
-
Novel N7-Arylmethyl Substituted Dinucleotide mRNA 50 cap Analogs: Synthesis and Evaluation as Modulators of Translation
- Authors:
- 1.Wójcik R., Baranowski M., Markiewicz Ł., Kubacka D., Bednarczyk M., Baran N., Wojtczak A., Sikorski P.J., Żuberek J., Kowalska J., Jemielity J.
- Academic press:
- Pharmaceutics (year: 2021, volume: 13(11), pages: 1941), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/pharmaceutics13111941 – link to the publication
-
Trinucleotide mRNA Cap Analogue N6-Benzylated at the Site of Posttranscriptional m6Am Mark Facilitates mRNA Purification and Confers Superior Translational Properties In Vitro and In Vivo
- Authors:
- Marcin Warminski, Edyta Trepkowska, Miroslaw Smietanski, Pawel J. Sikorski, Marek R. Baranowski, Marcelina Bednarczyk, Hanna Kedzierska, Bartosz Majewski, Adam Mamot, Diana Papiernik, Agnieszka Popielec, Remigiusz A. Serwa, Brittany A. Shimanski, Piotr Sklepkiewicz, Marta Sklucka, Olga Sokolowska, Tomasz Spiewla, Diana Toczydlowska-Socha, Zofia Warminska, Karol Wolosewicz, Joanna Zuberek, Jeffrey S. Mugridge, Dominika Nowis*, Jakub Golab*, Jacek Jemielity*, and Joanna Kowalska*
- Academic press:
- J. Am. Chem. Soc. (year: 2024, volume: 146, pages: 8149–8163), Publisher: American Chemical Society
- Status:
- Published
- DOI:
- 10.1021/jacs.3c12629 – link to the publication
-
Stereocontrolled access to thioisosteres of nucleoside di- and triphosphates
- Authors:
- Hai-Jun Zhang, Michał Ociepa, Molhm Nassir, Bin Zheng, Sarah A. Lewicki, Veronica Salmaso, Helay Baburi, Jessica Nagel, Salahuddin Mirza, Beatriz Bueschbell, Haneen Al-Hroub, Olga Perzanowska, Ziqin Lin, Michael A. Schmidt, Martin D. Eastgate, Kenneth A. Jacobson, Christa E. Müller, Joanna Kowalska, Jacek Jemielity & Phil S. Baran
- Academic press:
- Nature Chemistry (year: 2023, volume: 16, pages: 249–258), Publisher: Springer Nature
- Status:
- Published
- DOI:
- 10.1038/s41557-023-01347-2 – link to the publication
-
1 of 1 Chemical Modifications of mRNA Ends for Therapeutic Applications
- Authors:
- Marcin Warminski, Adam Mamot, Anaïs Depaix, Joanna Kowalska and Jacek Jemielity
- Academic press:
- Accounts of Chemical Research (year: 2023, volume: Volume 56 Issue 20, pages: 2814-2826), Publisher: American Chemical Society
- Status:
- Published
- DOI:
- 10.1021/acs.accounts.3c00442 – link to the publication
-
RNA Ligation for Mono and Dually Labeled RNAs
- Authors:
- Depaix A. Młynarska-Cieślak A., Warmiński M., Sikorski P.J., Jemielity J., Kowalska J.
- Academic press:
- Chemistry - A European Journal (year: 2021, volume: 27, pages: 12190-12197), Publisher: Wiley
- Status:
- Published
- DOI:
- 10.1002/chem.202101909 – link to the publication