Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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New nucleotide analogs containing triazole within oligophosphate bridge as mimics of the 5' end of mRNA - synthesis, properties and incorporation into mRNA at its 5' end

2015/17/N/ST5/03907

Keywords:

cap click chemistry triazole-containing mRNA trizole-modified nucleotides

Descriptors:

  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Sylwia Ciechanowicz 

Number of co-investigators in the project: 2

Call: PRELUDIUM 9 - announced on 2015-03-16

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2016-03-16

Project end date (Y-m-d): 2019-01-15

Project duration:: 34 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Termomikser (15 000 PLN)
  2. Aparat do elektroforezy pionowej (3 600 PLN)
  3. Lodówko-zamrażalka (3 000 PLN)
  4. Mieszadło magnetyczne (4 305 PLN)
  5. Waga laboratoryjna (2 041 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (1)
  1. A novel route for preparing 5′ cap mimics and capped RNAs: phosphate-modified cap analogues obtained via click chemistry
    Authors:
    Sylwia Walczak, Anna Nowicka, Dorota Kubacka, Kaja Fac, Przemyslaw Wanat, Seweryn Mroczek, Joanna Kowalska, Jacek Jemielity
    Academic press:
    Chemical Science (rok: 2017, tom: 8, strony: 260-267), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C6SC02437H - link to the publication
  2. Exploring the potential of phosphotriazole 5′ mRNA cap analogues as efficient translation initiators
    Authors:
    Sylwia Walczak, Pawel J. Sikorski, Renata Kasprzyk, Joanna Kowalska, Jacek Jemielity
    Academic press:
    Organic & Biomolecular Chemistry (rok: 2018, tom: 16, strony: 6741-6748), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C8OB01720D - link to the publication
  1. NOWA KLASA ANALOGÓW KOŃCA 5' mRNA O ULEPSZONYCH WŁAŚCIWOŚCIACH INICJACJI TRANSLACJI
    Authors:
    Sylwia Walczak, Anna Nowicka, Dorota Kubacka, Kaja Fac, Przemysław Wanat, Joanna Kowalska, Jacek Jemielity
    Conference:
    60 Zjazd Naukowy Polskiego Towarzystwa Chemicznego (rok: 2017, ), Wydawca: Polskie Towarzystwo Chemiczne
    Data:
    konferencja 17-21 września
    Status:
    Published

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