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Investigating the biological role of 5' nucleotidases cN-IIIA and cN-IIIB in mRNA degradation and their terapeutic significance using nucleotide-based molecular tools

2017/24/C/NZ1/00169

Keywords

Descriptors

  • NZ1_1: Biologia molekularna
  • ST5_16: Chemia biologiczna
  • ST5_23: Chemia organiczna

Panel

NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution

Uniwersytet Warszawski, Wydział Fizyki

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Dorota Maria Kubacka

Number of co-investigators in the project: 2

Call

SONATINA 1 – announced on 2016-12-15

Amount awarded
694 893 PLN
Project start date
2017-11-03
Project end date
2020-11-02
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (3)

  1. 7-Methylguanosine monophosphate analogues with 5′-(1,2,3-triazoyl) moiety: Synthesis and evaluation as the inhibitors of cNIIIB nucleotidase

    Authors:
    Mateusz Kozarski, Dorota Kubacka, Blazej A.Wojtczak, Renata Kasprzyk, Marek R.Baranowski, Joanna Kowalska
    Academic press:
    Bioorganic & Medicinal Chemistry (year: 2018, volume: 26, pages: 191-199), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmc.2017.11.032 – link to the publication

  2. Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism [Notatka: wraz z publikacją zostały zdeponowane struktury w bazie PDB o kodach: 7ZEE, 7ZEG, 7ZEH]

    Authors:
    Dorota Kubacka, Mateusz Kozarski, Marek R. Baranowski, Radoslaw Wojcik, Joanna Panecka-Hofman, Dominika Strzelecka, Jerome Basquin, Jacek Jemielity, Joanna Kowalska
    Academic press:
    Pharmaceuticals (year: 2022, volume: 15(5), 554, pages: 46049), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ph15050554 – link to the publication

  3. Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5′ cap Analogs: Synthesis and Evaluation as Modulators of Translation

    Authors:
    Radosław Wojcik, Marek R. Baranowski, Lukasz Markiewicz, Dorota Kubacka, Marcelina Bednarczyk, Natalia Baran, Anna Wojtczak, Pawel J. Sikorski, Joanna Zuberek, Joanna Kowalska, Jacek Jemielity
    Academic press:
    Pharmaceutics (year: 2021, volume: 13(11):1941, pages: 46041), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics13111941 – link to the publication

Articles in post-conference publications (4)

  1. Synthesis of novel m7GMP analogues and evaluation as the inhibitors of cNIIIB nucleotidase

    Authors:
    Mateusz Kozarski, Dorota Kubacka, Blazej A. Wojtczak, Renata Kasprzyk, Marek Baranowski, Joanna Kowalska
    Conference:
    XXIII International Roundtable of Nucleosides, Nucleotides and Nucleic Acids (year: 2018, pages: P185), Publisher: The International Society of Nucleosides, Nucleotides and Nucleic acids (IS3NA)
    Date:
    conference 26-30.08.2018
    Status:
    Published

  2. Synteza nowych analogów 5'-monofosforanu 7- metyloguanozyny oraz ich zastosowanie w badaniu roli ludzkiej 5'-nukleotydazy IIIB

    Authors:
    Kozarski M., Kubacka D., Baranowski M.R., Strzelecka D., Wojtczak A., Basquin J., Jemielity J., Kowalska J.,
    Conference:
    62 Zjazd Naukowy Polskiego Towarzystwa Chemicznego (year: 2019, pages: S15-26), Publisher: Polskie Towarzystwo Chemiczne
    Date:
    conference 2-6.09.2019
    Status:
    Published

  3. Structure-activity relationship approach in the rational design of cNIIIB enzyme inhibitors

    Authors:
    Kubacka D., Kozarski M., Baranowski M., Strzelecka D., Basquin J., Kowalska J.
    Conference:
    XVII Zjazd Polskiego Towarzystwa Biofizycznego (year: 2019, pages: 11), Publisher: Current Topics in Biophysics, Polish Biophysical Society
    Date:
    conference 24-27.06.2019
    Status:
    Published

  4. Structure-activity relationship approach in the rational design of cNIIIB enzyme inhibitors

    Authors:
    Kubacka D., Kozarski M., Baranowski M., Strzelecka D., Basquin J., Kowalska J.,
    Conference:
    7th International School on Biological Crystallization (year: 2019, pages: 136), Publisher: Laboratorio de Estudios Cristalograficos
    Date:
    conference 26-31.05.2019
    Status:
    Published

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