Projects funded by the NCN

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Information of the project and the call

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Investigating the biological role of 5' nucleotidases cN-IIIA and cN-IIIB in mRNA degradation and their terapeutic significance using nucleotide-based molecular tools

2017/24/C/NZ1/00169

Keywords:

5' nucleotidase mRNA cap degradation molecular probe nucleotides phosphatase enzymatic hydrolysis nucleotidase's inhibitors X-ray crystallography

Descriptors:

  • NZ1_1: Molecular biology
  • ST5_16:
  • ST5_23:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Warszawski, Wydział Fizyki

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Dorota Kubacka 

Number of co-investigators in the project: 2

Call: SONATINA 1 - announced on 2016-12-15

Amount awarded: 694 893 PLN

Project start date (Y-m-d): 2017-11-03

Project end date (Y-m-d): 2020-11-02

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (4)
  1. 7-Methylguanosine monophosphate analogues with 5′-(1,2,3-triazoyl) moiety: Synthesis and evaluation as the inhibitors of cNIIIB nucleotidase
    Authors:
    Mateusz Kozarski, Dorota Kubacka, Blazej A.Wojtczak, Renata Kasprzyk, Marek R.Baranowski, Joanna Kowalska
    Academic press:
    Bioorganic & Medicinal Chemistry (rok: 2018, tom: 26, strony: 191-199), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmc.2017.11.032 - link to the publication
  2. Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5′ cap Analogs: Synthesis and Evaluation as Modulators of Translation
    Authors:
    Radosław Wojcik, Marek R. Baranowski, Lukasz Markiewicz, Dorota Kubacka, Marcelina Bednarczyk, Natalia Baran, Anna Wojtczak, Pawel J. Sikorski, Joanna Zuberek, Joanna Kowalska, Jacek Jemielity
    Academic press:
    Pharmaceutics (rok: 2021, tom: 13(11):1941, strony: 45310), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics13111941 - link to the publication
  3. Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism [Notatka: wraz z publikacją zostały zdeponowane struktury w bazie PDB o kodach: 7ZEE, 7ZEG, 7ZEH]
    Authors:
    Dorota Kubacka, Mateusz Kozarski, Marek R. Baranowski, Radoslaw Wojcik, Joanna Panecka-Hofman, Dominika Strzelecka, Jerome Basquin, Jacek Jemielity, Joanna Kowalska
    Academic press:
    Pharmaceuticals (rok: 2022, tom: 15(5), 554, strony: 45318), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph15050554 - link to the publication
  1. Structure-activity relationship approach in the rational design of cNIIIB enzyme inhibitors
    Authors:
    Kubacka D., Kozarski M., Baranowski M., Strzelecka D., Basquin J., Kowalska J.,
    Conference:
    7th International School on Biological Crystallization (rok: 2019, ), Wydawca: Laboratorio de Estudios Cristalograficos
    Data:
    konferencja 26-31.05.2019
    Status:
    Published
  2. Synteza nowych analogów 5'-monofosforanu 7- metyloguanozyny oraz ich zastosowanie w badaniu roli ludzkiej 5'-nukleotydazy IIIB
    Authors:
    Kozarski M., Kubacka D., Baranowski M.R., Strzelecka D., Wojtczak A., Basquin J., Jemielity J., Kowalska J.,
    Conference:
    62 Zjazd Naukowy Polskiego Towarzystwa Chemicznego (rok: 2019, ), Wydawca: Polskie Towarzystwo Chemiczne
    Data:
    konferencja 2-6.09.2019
    Status:
    Published
  3. Structure-activity relationship approach in the rational design of cNIIIB enzyme inhibitors
    Authors:
    Kubacka D., Kozarski M., Baranowski M., Strzelecka D., Basquin J., Kowalska J.
    Conference:
    XVII Zjazd Polskiego Towarzystwa Biofizycznego (rok: 2019, ), Wydawca: Current Topics in Biophysics, Polish Biophysical Society
    Data:
    konferencja 24-27.06.2019
    Status:
    Published
  4. Synthesis of novel m7GMP analogues and evaluation as the inhibitors of cNIIIB nucleotidase
    Authors:
    Mateusz Kozarski, Dorota Kubacka, Blazej A. Wojtczak, Renata Kasprzyk, Marek Baranowski, Joanna Kowalska
    Conference:
    XXIII International Roundtable of Nucleosides, Nucleotides and Nucleic Acids (rok: 2018, ), Wydawca: The International Society of Nucleosides, Nucleotides and Nucleic acids (IS3NA)
    Data:
    konferencja 26-30.08.2018
    Status:
    Published

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