Projects funded by the NCN
Studies on a new method for the synthesis of oligoribonucleotides modified with 5-aminomethyluridines (xnm5U) and 5-aminomethyl-2-thiouridines (xnm5s2U) via post-synthetic nucleophilic substitution of 5-pivaloyloxymethyluridine/2-thiouridine
2015/17/N/ST5/03679
Keywords:
5-pivaloyloxyl group 5-aminomethyluridine/2-thiouridine modified oligoribonucleotides phosphoramidite method
Descriptors:
- ST5_16:
Panel:
ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering
Host institution :
Politechnika Łódzka, Wydział Chemiczny
woj. łódzkie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 9 - announced on 2015-03-16
Amount awarded: 99 400 PLN
Project start date (Y-m-d): 2016-03-03
Project end date (Y-m-d): 2018-03-02
Project duration:: 24 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Dwustopniowa pompa rotacyjna (ciśnienie w zakresie 10-3 mBar) (10 000 PLN)
Information in the final report
- Publication in academic press/journals (1)
- Post-synthetic conversion of 5-pivaloyloxymethyluridine present in a support-bound RNA oligomer into biologically relevant derivatives of 5-methyluridineAuthors:Karolina Bartosik, Elzbieta Sochacka, Grazyna LeszczynskaAcademic press:Organic & Biomolecular Chemistry (rok: 2017, tom: 15, strony: 2097-2103), Wydawca: Royal Society of ChemistryStatus:PublishedDOI:10.1039/C6OB02674E - link to the publication