Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Transformation of 5'-O-monothiophosphate nucleoside to 5'-O-monophosphate in the cell - possible metabolism of phosphorothioate drugs and prodrugs.

2013/09/B/ST5/03612

Keywords:

desulfuration monothiophosphate nucleoside hydrogen sulfide

Descriptors:

  • ST5_16:
  • ST5_25:
  • NZ3_2: Cell physiology

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Agnieszka Krakowiak 

Number of co-investigators in the project: 7

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 594 666 PLN

Project start date (Y-m-d): 2014-02-13

Project end date (Y-m-d): 2017-02-12

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Drukarka HP Laser Jet.
  2. System do mierzenia poziomu siarkowodoru w mediach biologicznych za pomocą mikroelektrody (14 000 PLN)
  3. Komputer typu desktop (4 000 PLN)
  4. Łaźnia orbitalna grzewczo-chłodząca (14 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (3)
  1. New interactions between tumor suppressor Fhit protein and a non-hydrolyzable analog of its AP4A substrate
    Authors:
    Krakowiak Agnieszka, Kocoń-Rębowska Beata, Dolot Rafał, Piotrzkowska Danuta
    Academic press:
    FEBS Letters (rok: 2017, tom: 591, strony: 548-559), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/1873-3468.12560 - link to the publication
  2. Interactions of cellular histidine triad nucleotide binding protein 1 with nucleosides 5'-O-monophosphorothioate and their derivatives - Implication for desulfuration process in the cell.
    Authors:
    Krakowiak Agnieszka, Pawłowska Róża, Kocoń-Rębowska Beata, Dolot Rafał, Stec Wojciech J.
    Academic press:
    Biochimica et Biophysica Acta (BBA) - General Subjects (rok: 2014, tom: 1840, strony: 3357-3366), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbagen.2014.08.016 - link to the publication
  1. The studies on the presence of functional P2X7 receptors at different cell lines
    Authors:
    Piotrzkowska Danuta, Pęczek Łukasz, Krakowiak Agnieszka
    Conference:
    49 Zjazd Polskiego Towarzystwa Biochemicznego, Warszawa (rok: 2014, ), Wydawca: Pawel Pomorski and Polish Biochemical Society
    Data:
    konferencja 9-12 września 2014
    Status:
    Published
  2. Comparison of the expression and functionality of P2X7 receptors sensitive to ATP and Bz-ATP activation at different cell lines
    Authors:
    Agnieszka Krakowiak, Danuta Piotrzkowska, Łukasz Pęczek
    Conference:
    40th FEBS Congress, Berlin – Niemcy (rok: 2015, ), Wydawca: John Wiley & Sons
    Data:
    konferencja 4–9 lipca 2015
    Status:
    Published
    DOI:
    link to the publication
  3. Desulfuration of nucleoside 5'-O-phosphorothioate with releasing of H2S in metabolism of phosphorothioate drugs and prodrugs
    Authors:
    A. Krakowiak, D. Piotrzkowska
    Conference:
    II Kongres BIO, Wrocław (rok: 2016, ), Wydawca: Pawel Pomorski and Polish Biochemical Society
    Data:
    konferencja 13-16.09.2016
    Status:
    Published
    DOI:
    link to the publication

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