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5-Hydroxymethylcytosine (sixth DNA base) and its putative derivative - 5-hydroxymethyluracil as a new cancer biomarkers?A search for a possible link among chronic inflammation - carcinogenesis and 5-hydroxymethylcytosine formation.

2013/09/B/NZ5/00767

Keywords

Descriptors

  • NZ5_3: Patogeneza chorób człowieka
  • NZ5_5: Diagnostyka chorób człowieka

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy; Wydział Farmaceutyczny

Voivodeship: kujawsko-pomorskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Ryszard Oliński

Number of co-investigators in the project: 13

Call

OPUS 5 – announced on 2013-03-15

Amount awarded
1 397 100 PLN
Project start date
2014-03-19
Project end date
2017-09-18
Project duration
42 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Komputery stacjonarne i mobilne z oprogramowaniem. Cost: 18 000 PLN
  2. Spektrofotometr UV/VIS. Cost: 70 000 PLN

Information in the final report

Publication in academic press/journals (6)

  1. Urinary 5-hydroxymethyluracil and 8-oxo-7,8-dihydroguanine as potential biomarkers in patients with colorectal cancer

    Authors:
    Rafal Rozalski, Daniel Gackowski, Agnieszka Siomek-Gorecka, Marta Starczak, Martyna Modrzejewska, Zbigniew Banaszkiewicz, Ryszard Olinski
    Academic press:
    Biomarkers (year: 2015, volume: 20 (5), pages: 287-291), Publisher: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.3109/1354750X.2015.1068860 – link to the publication

  2. Characteristic profiles of DNA epigenetic modifications in colon cancer and its predisposing conditions—benign adenomas and inflammatory bowel disease

    Authors:
    Dziaman T, Gackowski D, Guz J, Linowiecka K, Bodnar M, Starczak M, Zarakowska E, Modrzejewska M, Szpila A, Szpotan J, Gawronski M, Labejszo A, Liebert A, Banaszkiewicz Z, Klopocka M, Foksinski M, Marszalek A, Olinski R.
    Academic press:
    CLINICAL EPIGENETICS (year: 2018, volume: 10, pages: Article Number: 72), Publisher: BIOMED CENTRAL LTD
    Status:
    Published
    DOI:
    10.1186/s13148-018-0505-0 – link to the publication

  3. In vivo evidence of ascorbate involvement in the generation of epigenetic DNA modifications in leukocytes from patients with colorectal carcinoma, benign adenoma and inflammatory bowel disease

    Authors:
    Starczak M, Zarakowska E, Modrzejewska M, Dziaman T, Szpila A, Linowiecka K, Guz J, Szpotan J, Gawronski M, Labejszo A, Liebert A, Banaszkiewicz Z, Klopocka M, Foksinski M, Gackowski D, Olinski R.
    Academic press:
    JOURNAL OF TRANSLATIONAL MEDICINE (year: 2018, volume: 16, pages: Article Number: 204), Publisher: BMC
    Status:
    Published
    DOI:
    10.1186/s12967-018-1581-9 – link to the publication

  4. Accurate, Direct, and High-Throughput Analyses of a Broad Spectrum of Endogenously Generated DNA Base Modifications with Isotope-Dilution Two-Dimensional Ultraperformance Liquid Chromatography with Tandem Mass Spectrometry: Possible Clinical Implication.

    Authors:
    Gackowski D, Starczak M, Zarakowska E, Modrzejewska M, Szpila A, Banaszkiewicz Z, Olinski R.
    Academic press:
    ANALYTICAL CHEMISTRY (year: 2016, volume: 88(24), pages: 12128-12136), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.analchem.6b02900 – link to the publication

  5. Urinary Measurement of Epigenetic DNA Modifications: A Non-Invasive Assessment of the Whole-Body Epigenetic Status in Healthy Subjects and Colorectal Cancer Patients.

    Authors:
    Rozalski R, Gackowski D, Siomek-Gorecka A, Banaszkiewicz Z, Olinski R.
    Academic press:
    ChemistryOpen (year: 2016, volume: 5, pages: 550 – 553), Publisher: WILEY-V C H VERLAG GMBH
    Status:
    Published
    DOI:
    10.1002/open.201600103 – link to the publication

  6. Endogenously generated DNA nucleobase modifications source, and significance as possible biomarkers of malignant transformation risk, and role in anticancer therapy

    Authors:
    Ryszard Olinski, Daniel Gackowski and Marcus S. Cooke
    Academic press:
    BBA Reviews on Cancer (year: 2018, volume: 1869, pages: 29-41), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbcan.2017.11.002 – link to the publication

Articles in post-conference publications (6)

  1. Urinary levels of DNA damage markers and active demethylation products of 5- metylcytosine – a non-invasive assessment of the whole-body epigenetic status.

    Authors:
    R. Rozalski, D. Gackowski, A. Siomek-Gorecka, Z. Banaszkiewicz, R. Olinski
    Conference:
    The 42nd FEBS Congress From Molecules to Cells and Back (year: 2017, pages: 223), Publisher: The FEBS Journal
    Date:
    conference 10-14 September
    Status:
    Published

  2. Distinct pattern of epigenetic DNA modifications in leukocytes of colorectal carcinoma patients and in patients with precancerous conditions - benign adenoma and inflammatory bowel diseases.

    Authors:
    M. Starczak, E. Zarakowska, M. Modrzejewska, T. Dziaman, A. Szpila, K. Linowiecka, J. Guz, J. Szpotan, M. Gawronski, A. Labejszo, Z. Banaszkiewicz, M. Klopocka, R. Olinski, D. Gackowski
    Conference:
    The 42nd FEBS Congress From Molecules to Cells and Back (year: 2017, pages: 221-222), Publisher: The FEBS Journal
    Date:
    conference 10-14 September
    Status:
    Published

  3. Glutarate derivatives as modulators of TET proteins activity. The level of L-2- hydroxyglutarate is significantly increased among colorectal cancer patients compared to controls.

    Authors:
    M. Modrzejewska, D. Gackowski, J. Szpotan, Z. Banaszkiewicz, R. Olinski, M. Foksinski
    Conference:
    The 42nd FEBS Congress From Molecules to Cells and Back (year: 2017, pages: 226), Publisher: The FEBS Journal
    Date:
    conference 10-14 September
    Status:
    Published

  4. AKTYWNA DEMETYLACJA DNA: MECHANIZMY I FUNKCJE BIOLOGICZNE – ZNACZENIA W DIAGNOSTYCE NOWOTWORÓW

    Authors:
    Ryszard Oliński, Marek Foksiński, Daniel Gackowski
    Conference:
    Genetyczne i środowiskowe uwarunkowania zdrowia − biomarkery narażenia, efektu i wrażliwości (year: 2016, pages: 26-27), Publisher: Polskie Towarzystwo Toksykologiczne
    Date:
    conference 30.05-01.06
    Status:
    Published

  5. OCENA ROLI WITAMINY C, 2-KETOGLUTARANU I 2-HYDROKSYGLUTARANU W KANCEROGENEZIE PRZEZ PRYZMAT AKTYWNEJ DEMETYLACJI DNA

    Authors:
    Marek Foksiński, Daniel Gackowski, Ryszard Oliński
    Conference:
    Genetyczne i środowiskowe uwarunkowania zdrowia − biomarkery narażenia, efektu i wrażliwości (year: 2016, pages: 28-29), Publisher: Polskie Towarzystwo Toksykologiczne
    Date:
    conference 30.05-01.06
    Status:
    Published

  6. PROFIL MODYFIKACJI EPIGENETYCZNYCH DNA I BIOMARKERÓW STRESU OKSYDACYJNEGO W NOWOTWORACH JELITA GRUBEGO

    Authors:
    Daniel Gackowski, Marek Foksiński, Ryszard Oliński
    Conference:
    Genetyczne i środowiskowe uwarunkowania zdrowia − biomarkery narażenia, efektu i wrażliwości (year: 2016, pages: 30-31), Publisher: Polskie Towarzystwo Toksykologiczne
    Date:
    conference 30.05-01.06
    Status:
    Published

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