Projects funded by the NCN

Inhibitors of BTLA-HVEM complex formation as potential targets for cancer immunotheraphy

Call: SONATA 13 , Panel: ST5

Principal investigator: dr Marta Spodzieja

Uniwersytet Gdański, Wydział Chemii

De novo designed, structurally extended peptide foldamers and their use for construction of PD-1/PD-L1 interaction inhib...

Call: OPUS 16 , Panel: ST5

Principal investigator: dr hab. Łukasz Berlicki

Politechnika Wrocławska

Identification of amino acid residues located in positions P7 and P8 of model inhibitor of proprotein convertases that d...

Call: PRELUDIUM 3 , Panel: ST5

Principal investigator: Izabela Małuch

Uniwersytet Gdański, Wydział Chemii

Conjugates of prion protein with dendrimers as inhibitors of Abeta peptide amyloidogenesis and cytotoxicity of potential...

Call: HARMONIA 5 , Panel: NZ4

Principal investigator: dr hab. Krzysztof Nieznański

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Blocking the TNF-TNFR2 interactions as a novel approach to the ovarian carcinoma treatment

Call: OPUS 21 , Panel: NZ7

Principal investigator: prof. Sylwia Anna Rodziewicz-Motowidło

Uniwersytet Gdański, Wydział Chemii

SELECTIVE REGULATION OF RAB GTPASES BY TARGETING PROTEIN-PROTEIN INTERACTIONS BETWEEN RABS AND REGULATORY PROTEINS

Call: PRELUDIUM BIS 3 , Panel: ST4

Principal investigator: dr hab. Katarzyna Magdalena Błażewska

Politechnika Łódzka, Wydział Chemiczny

The design and development of the peptide inhibitors library targeting Zn(II)-binding site of matrix metalloproteinases ...

Call: PRELUDIUM 22 , Panel: ST5

Principal investigator: Paulina Alicja Potok

Uniwersytet Wrocławski, Wydział Chemii

Frog skin derived cyclic peptide as a molecular scaffold to create a novel tool for combining visualization and inhibiti...

Call: PRELUDIUM 23 , Panel: ST5

Principal investigator: Aleksandra Helbik-Maciejewska

Uniwersytet Gdański

Synthesis and evaluation of PD-L1 inhibitors based on mixed mode scaffolds containing amino acid derivatives, short pept...

Call: SONATA 16 , Panel: ST4

Principal investigator: dr Ewa Maria Surmiak

Uniwersytet Jagielloński, Wydział Chemii

Hydrogen exchange mass spectrometry (HXMS) for studying human serum amyloid A fibril formation.

Call: PRELUDIUM 2 , Panel: NZ5

Principal investigator: Marta Sosnowska

Uniwersytet Gdański, Wydział Chemii

Identification of key structural elements of immunomodulatory proteins - inhibitors of antigenic peptide transporter TAP...

Call: SONATA 18 , Panel: NZ7

Principal investigator: dr Natalia Karska

Uniwersytet Gdański, Wydział Chemii

Computational alchemy and experimental validation: a hybrid approach for designing new antimicrobial peptides

Call: PRELUDIUM 22 , Panel: NZ1

Principal investigator: Piotr Maciej Chyży

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Investigation of the effect of thiol group and urea bond on the peptidomimetics' affinity to receptors associated with a...

Call: PRELUDIUM 14 , Panel: NZ7

Principal investigator: dr Anna Puszko

Uniwersytet Warszawski, Wydział Chemii

Characterization of hydrolysates and peptides derived from oat kernels proteins in the context of their activity in dise...

Call: PRELUDIUM 16 , Panel: NZ9

Principal investigator: dr Monika Pliszka

Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Nauki o Żywności

Multifunctional inhibitors of beta-secretase with anti-aggregating properties of neurotoxic peptides - beta-amyloid and ...

Call: OPUS 11 , Panel: NZ7

Principal investigator: prof. Barbara Malawska

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Blocking HVEM/LIGHT interactions using peptides - an innovative approach to immunosuppression

Call: PRELUDIUM BIS 2 , Panel: ST4

Principal investigator: dr hab. Adam Kazimierz Sieradzan

Uniwersytet Gdański, Wydział Chemii

Studies on the metal ions impact on the structure and functions of peptidic inhibitors of aggregation of proteins involv...

Call: OPUS 1 , Panel: ST5

Principal investigator: dr Marek Łuczkowski

Uniwersytet Wrocławski, Wydział Chemii

Inhibitors, protein aggregation and carbon nanotube

Call: OPUS 1 , Panel: NZ1

Principal investigator: dr hab. Mai Li

INSTYTUT FIZYKI PAN

SLPI-dependent cutaneous antimicrobial and antiviral immunity.

Call: OPUS 13 , Panel: NZ6

Principal investigator: prof. Joanna Cichy

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Design, chemical synthesis and enzymatic evaluation of peptidic substrates and inhibitors of cathepsin C

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: dr Monika Łęgowska

Uniwersytet Gdański, Wydział Chemii

Effects of proteasome inhibition on mitochondrial homeostasis.

Call: OPUS 17 , Panel: NZ5

Principal investigator: prof. Agnieszka Małgorzata Chacińska

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Peptide splicing - the mechanism and its application for designing compounds with potential use in medicinal practice

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Krzysztof Rolka

Uniwersytet Gdański, Wydział Chemii

Morita-Baylis-Hillman adducts as substrates in the synthesis of biologically active organophosphorus compounds

Call: OPUS 5 , Panel: ST5

Principal investigator: dr hab. Artur Mucha

Politechnika Wrocławska, Wydział Chemiczny

Novel peptide inhibitors of dipeptidyl peptidase IV (DPP IV) as novel approach for diabetes type 2 and inflammatory bowe...

Call: PRELUDIUM 6 , Panel: NZ7

Principal investigator: Maciej Sałaga

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Design, chemical synthesis and biological activity of inhibitors of matriptase-2.

Call: PRELUDIUM 7 , Panel: ST5

Principal investigator: Agata Gitlin-Domagalska

Uniwersytet Gdański, Wydział Chemii

Inhibiting the Mitochondrial Intermembrane Space Assembly pathway as a newapproach to prevent metabolic reprogramming of...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr hab. Carlo Vascotto

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Proteins of dry-cured pork loins with the addition of a probiotic bacterial strain as a potential source od peptides wit...

Call: PRELUDIUM 15 , Panel: NZ9

Principal investigator: dr Paulina Kęska

Uniwersytet Przyrodniczy w Lublinie, Wydział Nauk o Żywności i Biotechnologii