Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Studies on the metal ions impact on the structure and functions of peptidic inhibitors of aggregation of proteins involved in neurodegenerative disorders

2011/01/B/ST5/03936

Keywords:

beta-amyloid peptide BRI aggregation neurodegenerative disorders Cu Hg Ag

Descriptors:

  • ST5_14: Other related subjects
  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Wrocławski, Wydział Chemii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marek Łuczkowski 

Number of co-investigators in the project: 2

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 650 010 PLN

Project start date (Y-m-d): 2011-12-21

Project end date (Y-m-d): 2015-09-20

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Kalorymetr Miareczkujący ITC (380 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (7)
  1. Copper, zinc and iron in neurodegenerative diseases (Alzheimer's, Parkinson's and prion diseases)
    Authors:
    Henryk Kozłowski, Marek Łuczkowski, Maurizio Remelli, Daniela Valensin
    Academic press:
    Coordination Chemistry Rewievs (rok: 2012, tom: 256, strony: 2129– 2141), Wydawca: Elsevrer
    Status:
    Published
    DOI:
    10.1016/j.ccr.2012.03.013 - link to the publication
  2. Metal ion mediated transition from random coil to β-sheet and aggregation of Bri2-23, a natural inhibitor of Aβ aggregation
    Authors:
    Marek Luczkowski, Riccardo De Ricco, Monika Stachura, Slawomir Potocki, Lars Hemmingsen and Daniela Valensin
    Academic press:
    Metallomics (rok: 2015, tom: n.a., strony: n.a), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C4MT00274A - link to the publication
  3. Copper induced structural propensities of the amyloidogenic region of human Prion Protein
    Authors:
    Caterina Migliorini, Adalgisa Sinicropi, Henryk Kozlowski, Marek Luczkowski, Daniela Valensin
    Academic press:
    Journal of Biological Inorganic Chemistry (rok: 2014, tom: 19, strony: 635-645), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00775-014-1132-7 - link to the publication
  4. Specific binding modes of Cu(I) and Ag(I) with neurotoxic domain of the human prion protein
    Authors:
    Daniela Valensin, Emilia Maria Padula, Aleksandra Hecel, Marek Luczkowski, Henryk Kozlowski
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2016, tom: 155, strony: 26-35), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2015.11.015 - link to the publication
  1. Probing Cu(I) binding properties of two toxic mutants of the human prion protein fragment
    Authors:
    Aleksandra Hecel, Marek Luczkowski, Daniela Valensin
    Conference:
    12th European Biological Inorganic Chemistry Conference, Zurich, Switzerland (rok: 2014, ), Wydawca: Journal of Biological Inorganic Chemistry, Springer
    Data:
    konferencja 24–28 Sierpnia 2014
    Status:
    Published
    DOI:
    link to the publication
  2. Probing Cu+ Binding Properties of Cysteine-Rich Fragment of BRI2 and Amyloid-β Fragment
    Authors:
    Marek Luczkowski, Aleksandra Hecel, Agnieszka Pieciuń, Daniela Valensin
    Conference:
    XII International Symposium on Inorganic Biochemistry (rok: 2013, ), Wydawca: Wydział Chemii Uniwersytetu Wrocławskiego
    Data:
    konferencja 28 sierpnia - 1 września 2013
    Status:
    Published
  3. Probing Cu+ Binding Properties of Cysteine-Rich Fragment of BRI2 and Amyloid-β Fragment
    Authors:
    Marek Luczkowski, Agnieszka Pieciun, Daniela Valensin
    Conference:
    XVIth International Conference on Biological Inorganic Chemistry (rok: 2013, ), Wydawca: Springer
    Data:
    konferencja 22-26 Lipca 2013
    Status:
    Published
  4. BIOINORGANIC CHEMISTRY OF BRI2-23 AN NATURAL AMYLOIDβ AGGREGATION INHIBITOR
    Authors:
    Marek Luczkowski, Ricardo De Ricco, Daniela Valensin
    Conference:
    European Chemistry Congress - 5th EuCheMS (rok: 2014, ), Wydawca: Turkish Chemical Society/EUChemS
    Data:
    konferencja 31 Sierpień - 4 Wrzesień 2014
    Status:
    Published
    DOI:
    link to the publication
  5. Impact of SDS surfactant on the interaction aof Cu2+ ions with amyloidogenic region of human prion protein
    Authors:
    Aleksandra Hecel, Caterina Migliorini, Daniela Valensin, Marek Luczkowski, Henryk Kozlowski
    Conference:
    13th International Symposium On Applied Bioinorganic Chemistry (rok: 2015, ), Wydawca: NUI Galway
    Data:
    konferencja 12-15 Czerwiec 2015
    Status:
    Published
  6. Probing Cu+ Binding Properties of Cysteine-Rich Fragment of BRI-2
    Authors:
    Marek Luczkowski, Aleksandra Hecel, Sławomir Potocki, Daneila Valensin
    Conference:
    5th Georgian Bay International Conference on Bioinorganic Chemistry (rok: 2015, ), Wydawca: The University of Western Ontario, London, Ontario, Canada
    Data:
    konferencja 19-23 Maja 2015
    Status:
    Published
  7. Probing Cu+ binding properties of cysteine-rich fragment of BRI2, natural inhibitor of β-amyloid deposition.
    Authors:
    Łuczkowski Marek, Daniela Valensin
    Conference:
    11th European Biological Inorganic Chemistry Conference EUROBIC 11 (rok: 2012, ), Wydawca: University of Granada
    Data:
    konferencja 12-16 IX 2012
    Status:
    Published

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