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Studies on the metal ions impact on the structure and functions of peptidic inhibitors of aggregation of proteins involved in neurodegenerative disorders

2011/01/B/ST5/03936

Keywords

Descriptors

  • ST5_14: Chemia koordynacyjna
  • ST5_16: Chemia biologiczna

Panel

ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution

Uniwersytet Wrocławski, Wydział Chemii

Voivodeship: dolnośląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Marek Józef Łuczkowski

Number of co-investigators in the project: 2

Call

OPUS 1 – announced on 2011-03-15

Amount awarded
650 010 PLN
Project start date
2011-12-21
Project end date
2015-09-20
Project duration
45 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Kalorymetr Miareczkujący ITC. Cost: 380 000 PLN

Information in the final report

Publication in academic press/journals (4)

  1. Specific binding modes of Cu(I) and Ag(I) with neurotoxic domain of the human prion protein

    Authors:
    Daniela Valensin, Emilia Maria Padula, Aleksandra Hecel, Marek Luczkowski, Henryk Kozlowski
    Academic press:
    Journal of Inorganic Biochemistry (year: 2016, volume: 155, pages: 26-35), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2015.11.015 – link to the publication

  2. Copper, zinc and iron in neurodegenerative diseases (Alzheimer's, Parkinson's and prion diseases)

    Authors:
    Henryk Kozłowski, Marek Łuczkowski, Maurizio Remelli, Daniela Valensin
    Academic press:
    Coordination Chemistry Rewievs (year: 2012, volume: 256, pages: 2129– 2141), Publisher: Elsevrer
    Status:
    Published
    DOI:
    10.1016/j.ccr.2012.03.013 – link to the publication

  3. Metal ion mediated transition from random coil to β-sheet and aggregation of Bri2-23, a natural inhibitor of Aβ aggregation

    Authors:
    Marek Luczkowski, Riccardo De Ricco, Monika Stachura, Slawomir Potocki, Lars Hemmingsen and Daniela Valensin
    Academic press:
    Metallomics (year: 2015, volume: n.a., pages: n.a), Publisher: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C4MT00274A – link to the publication

  4. Copper induced structural propensities of the amyloidogenic region of human Prion Protein

    Authors:
    Caterina Migliorini, Adalgisa Sinicropi, Henryk Kozlowski, Marek Luczkowski, Daniela Valensin
    Academic press:
    Journal of Biological Inorganic Chemistry (year: 2014, volume: 19, pages: 635-645), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00775-014-1132-7 – link to the publication

Articles in post-conference publications (7)

  1. Impact of SDS surfactant on the interaction aof Cu2+ ions with amyloidogenic region of human prion protein

    Authors:
    Aleksandra Hecel, Caterina Migliorini, Daniela Valensin, Marek Luczkowski, Henryk Kozlowski
    Conference:
    13th International Symposium On Applied Bioinorganic Chemistry (year: 2015, pages: 123), Publisher: NUI Galway
    Date:
    conference 12-15 Czerwiec 2015
    Status:
    Published

  2. Probing Cu(I) binding properties of two toxic mutants of the human prion protein fragment

    Authors:
    Aleksandra Hecel, Marek Luczkowski, Daniela Valensin
    Conference:
    12th European Biological Inorganic Chemistry Conference, Zurich, Switzerland (year: 2014, pages: S812), Publisher: Journal of Biological Inorganic Chemistry, Springer
    Date:
    conference 24–28 Sierpnia 2014
    Status:
    Published
    DOI:
    link to the publication

  3. Probing Cu+ binding properties of cysteine-rich fragment of BRI2, natural inhibitor of β-amyloid deposition.

    Authors:
    Łuczkowski Marek, Daniela Valensin
    Conference:
    11th European Biological Inorganic Chemistry Conference EUROBIC 11 (year: 2012, pages: 112), Publisher: University of Granada
    Date:
    conference 12-16 IX 2012
    Status:
    Published

  4. Probing Cu+ Binding Properties of Cysteine-Rich Fragment of BRI-2

    Authors:
    Marek Luczkowski, Aleksandra Hecel, Sławomir Potocki, Daneila Valensin
    Conference:
    5th Georgian Bay International Conference on Bioinorganic Chemistry (year: 2015, pages: 68), Publisher: The University of Western Ontario, London, Ontario, Canada
    Date:
    conference 19-23 Maja 2015
    Status:
    Published

  5. Probing Cu+ Binding Properties of Cysteine-Rich Fragment of BRI2 and Amyloid-β Fragment

    Authors:
    Marek Luczkowski, Agnieszka Pieciun, Daniela Valensin
    Conference:
    XVIth International Conference on Biological Inorganic Chemistry (year: 2013, pages: S392), Publisher: Springer
    Date:
    conference 22-26 Lipca 2013
    Status:
    Published

  6. Probing Cu+ Binding Properties of Cysteine-Rich Fragment of BRI2 and Amyloid-β Fragment

    Authors:
    Marek Luczkowski, Aleksandra Hecel, Agnieszka Pieciuń, Daniela Valensin
    Conference:
    XII International Symposium on Inorganic Biochemistry (year: 2013, pages: 34), Publisher: Wydział Chemii Uniwersytetu Wrocławskiego
    Date:
    conference 28 sierpnia - 1 września 2013
    Status:
    Published

  7. BIOINORGANIC CHEMISTRY OF BRI2-23 AN NATURAL AMYLOIDβ AGGREGATION INHIBITOR

    Authors:
    Marek Luczkowski, Ricardo De Ricco, Daniela Valensin
    Conference:
    European Chemistry Congress - 5th EuCheMS (year: 2014, pages: 490), Publisher: Turkish Chemical Society/EUChemS
    Date:
    conference 31 Sierpień - 4 Wrzesień 2014
    Status:
    Published
    DOI:
    link to the publication

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