Projects funded by the NCN

The influence of non-trivial topology on protein degradation by ClpXP in the context of degron design.

Call: OPUS 29 , Panel: NZ1

Principal investigator: dr Fernando Bruno da Silva

Uniwersytet Warszawski

Stealth" asparaginases as improved protein drugs for the treatment of childhood acute lymphoblastic leukemia (ALL)

Call: OPUS 27 , Panel: NZ1

Principal investigator: prof. Matthias Bochtler

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Search for novel IKK-β inhibitors in the context of diseases with neuroinflammatory origin – structure-based drug design...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Emilia Aleksandra Sługocka

Uniwersytet Jagielloński, Collegium Medicum

"I like to move it, move it" – molecular dynamics-driven optimization of ligand residence time as an opportunity to impr...

Call: OPUS 25 , Panel: NZ7

Principal investigator: dr hab. Sabina Marta Podlewska

Instytut Farmakologii PAN

New applications of non-conventional nonempirical methodologies for the analysis of catalytic and inhibitory properties ...

Call: OPUS 25 , Panel: ST4

Principal investigator: dr Edyta Dyguda-Kazimierowicz

Politechnika Wrocławska

Decrypting the "sulfation code" of glycosaminoglycans for understanding their function in the extracellular matrix

Call: OPUS 25 , Panel: ST4

Principal investigator: dr hab. Sergey Samsonov

Uniwersytet Gdański, Wydział Chemii

Targeted inhibition of hypusination pathway

Call: OPUS 24 , Panel: NZ7

Principal investigator: dr Przemysław Marek Grudnik

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Computational deciphering of pro-ferroptotic cell death protein machinery as a fundamental step in the search for therap...

Call: SONATA BIS 12 , Panel: ST4

Principal investigator: dr hab. Karolina Anna Mikulska-Rumińska

Uniwersytet Mikołaja Kopernika, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Thermodynamic contribution of halogen bonds in protein-ligand systems. Design, synthesis, and thermodynamic studies of m...

Call: PRELUDIUM 21 , Panel: ST4

Principal investigator: dr Sławomir Jan Kasperowicz

Instytut Biochemii i Biofizyki PAN

Novel broad-spectrum central nervous system active substances: optimization of their multi-target profile

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Anna Kaczor

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

efFect of nanoscale, three dimensIonal arrangement of proteins on biological and Therapeutic activity (FIT)

Call: OPUS 22 (LAP) , Panel: NZ1

Principal investigator: dr Antonina Naskalska

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Self-learning systems in the design of compounds modulating GPCR receptors activation.

Call: OPUS 20 , Panel: NZ2

Principal investigator: dr hab. Dorota Latek

Uniwersytet Warszawski, Wydział Chemii

Blocking HVEM/LIGHT interactions using peptides - an innovative approach to immunosuppression

Call: PRELUDIUM BIS 2 , Panel: ST4

Principal investigator: dr hab. Adam Kazimierz Sieradzan

Uniwersytet Gdański, Wydział Chemii

Development of tools for the rational design of peptide therapeutics

Call: OPUS 20 , Panel: NZ2

Principal investigator: dr hab. Sebastian Kmiecik

Uniwersytet Warszawski, Centrum Nauk Biologiczno-Chemicznych

Novel L-asparaginases as potential therapeutic agents and antimicrobial targets: structural and functional studies of en...

Call: OPUS 19 , Panel: NZ1

Principal investigator: prof. Mariusz Jaskólski

Instytut Chemii Bioorganicznej PAN

Molecular mechanisms, signal transduction and inhibition of PEBP1-15LOX protein complex triggering the ferroptotic cell ...

Call: SONATA 15 , Panel: ST4

Principal investigator: dr hab. Karolina Anna Mikulska-Rumińska

Uniwersytet Mikołaja Kopernika, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Connecting Artificial Protein Cages

Call: MAESTRO 11 , Panel: NZ1

Principal investigator: dr hab. Jonathan Gardiner Heddle

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Histidine Biosynthetic Pathway in Plants: Structural and Functional Studies as a Framework for the Design of Inhibitors ...

Call: SONATA 14 , Panel: NZ1

Principal investigator: dr hab. Miłosz Ruszkowski

Instytut Chemii Bioorganicznej PAN

Structural studies of signaling receptors HVEM/CD160 as potential targets for immunoterapy against melanoma

Call: SONATA 11 , Panel: NZ1

Principal investigator: dr Marta Orlikowska

Uniwersytet Gdański, Wydział Chemii

Design of new protein structures with precisely defined features using parametric models.

Call: SONATA BIS 5 , Panel: NZ1

Principal investigator: dr Stanisław Dunin-Horkawicz

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Design and synthesis of probes for RabGGTase profiling and their application for identification of the site of phosphono...

Call: SONATA BIS 4 , Panel: ST5

Principal investigator: dr hab. Katarzyna Błażewska

Politechnika Łódzka, Wydział Chemiczny

Design, parametrization and implementation of potentials of amino acid side chain interactions in water for application ...

Call: SONATA BIS 3 , Panel: ST4

Principal investigator: dr hab. Mariusz Makowski

Uniwersytet Gdański, Wydział Chemii

Designer nucleases from a structural and practical point of view

Call: MAESTRO 1 , Panel: NZ1

Principal investigator: prof. Matthias Bochtler

Instytut Biochemii i Biofizyki PAN