Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Dendimers as a platform for designing biologically active carrier

2016/23/B/ST5/02788

Keywords:

PAMAM dendrimers complex PAMAM-protein bioactive complex PAMAM dendrimer

Descriptors:

  • ST5_3: Surface modification
  • ST5_4: Thin films
  • ST5_19:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Barbara Jachimska 

Number of co-investigators in the project: 11

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 037 760 PLN

Project start date (Y-m-d): 2017-07-04

Project end date (Y-m-d): 2021-07-03

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Dichroiz kołowy (CD) (420 000 PLN)

Information in the final report

  • Publication in academic press/journals (12)
  • Articles in post-conference publications (29)
  • Book publications / chapters in book publications (1)
  1. Adsorption and Conformation Behavior of Lysozyme on Gold Surface Determined by QCM-D, MP-SPR, and FTIR
    Authors:
    P. Komorek, E. Martin, B. Jachimska
    Academic press:
    Int. J. Mol. Sci. (rok: 2021, tom: 22, strony: 1322), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22031322 - link to the publication
  2. Characterization of G4 PAMAM Dendrimer Complexes with 5-Fluorouracil and their Interactions with Bovine Serum Albumin
    Authors:
    K. Tokarczyk, B. Jachimska
    Academic press:
    Colloids and Surfaces A (rok: 2019, tom: 561, strony: 357-363), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.080 - link to the publication
  3. Mechanism of lysozyme adsorption onto gold surface determined by quartz crystal microbalance and surface plasmon resonance
    Authors:
    P. Komorek, M. Wałek, B. Jachimska
    Academic press:
    Bioelectrochemistry (rok: 2020, tom: 135, strony: 107582), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioelechem.2020.107582 - link to the publication
  4. Adsorption of lysozyme on gold surfaces in the presence of an external electric potential
    Authors:
    P. Komorek, B. Jachimska, I. Brand
    Academic press:
    Bioelectrochemistry (rok: 2021, tom: 142, strony: 107946), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioelechem.2021.107946 - link to the publication
  5. Adsorption of β-lactoglobulin A on gold surface determined in situ by QCM-D measurements
    Authors:
    S. Światek, P. Komorek, B. Jachimska
    Academic press:
    Food Hydrocolloids (rok: 2019, tom: 91, strony: 48-56), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.foodhyd.2019.01.007 - link to the publication
  6. Polyallylamine hydrochloride coating enhances the fluorescence emission of Human Serum Albumin encapsulated gold nanoclusters
    Authors:
    B. A. Russell1, B. Jachimska, Y. Chen
    Academic press:
    Journal of Photochemistry & Photobiology, B: Biology, (rok: 2018, tom: 187, strony: 131-137), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jphotobiol.2018.08.018 - link to the publication
  7. Analysis of dendrimer-protein interactions and their implications on potential applications of dendrimers in nanomedicine
    Authors:
    J. M. Rae and B. Jachimska
    Academic press:
    Nanoscale (rok: 2021, tom: 13, strony: 2703-20713), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/d0nr07607d - link to the publication
  8. Detecting Lysozyme Unfolding via the Fluorescence of Lysozyme Encapsulated Gold Nanoclusters
    Authors:
    N. Alkudasi, B. A. Russell, B. Jachimska, D. Birch, Y. Chen
    Academic press:
    J. Mater. Chem. B (rok: 2019, tom: 7, strony: 1167-1175), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/c9tb00009g - link to the publication
  9. Poly(amidoamine) dendrimers as nanocarriers for 5-fluorouracil: effectiveness of complex formation and cytotoxicity studies
    Authors:
    M. Szota, K. Reczyńska-Kolman, E. Pamuła, O. Michel, J. Kulbacka, B. Jachimska
    Academic press:
    Jnt. J.Mol. Sci. (rok: 2021, tom: 22, strony: 11167), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222011167 - link to the publication
  10. β-lactoglobulin as a potential carrier for bioactive molecules
    Authors:
    S. Świątek, P. Komorek, G. Turner, B. Jachimska
    Academic press:
    Bioelectrochemistry (rok: 2019, tom: 126, strony: 137-145), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioelechem.2018.12.006 - link to the publication
  11. Adsorption effectiveness of β-lactoglobulin onto gold surface determined by quartz crystal microbalance
    Authors:
    B. Jachimska, S. Świątek, J. I. Loch, K. Lewiński, T. Luxbacher
    Academic press:
    Bioelectrochemistry (rok: 2018, tom: 121, strony: 95-104), Wydawca: Elsevier
    Status:
    Published
    DOI:
    0.1016/j.bioelechem.2018.01.010 - link to the publication
  12. Protein interactions with negatively charged inorganic surfaces: simulation and experiment
    Authors:
    K. Kubiak-Ossowska, B. Jachimska, M. A. Qaraghuli, P. A. Mulheran
    Academic press:
    Current Opinion in Colloid & Interface Science (rok: 2019, tom: 41, strony: 104-117), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cocis.2019.02.001 - link to the publication
  1. Changes In Lysozyme's II-Structure as a Result of its Interaction with a Gold Surface – Preferred Conditions for Lysozyme's Aggregates Formation in Neurodegenerative Disease Development
    Authors:
    P. Komorek, I. Brand, B. Jachimska
    Conference:
    3rd Wroclaw Scientific Meetings (rok: 2019, ), Wydawca: Uniwersytet Wrocławski
    Data:
    konferencja 01.02-02.02
    Status:
    Published
  2. Combining Surface Plasmon Resonance and Quartz Crystal Microbalance to Determine Hydration of Dendrimer Monolayers
    Authors:
    B. Jachimska
    Conference:
    6th Annual Conference of AnalytiX 2018 (AnalytiX-2018) Session 307: Advances in Applied Spectroscopy (rok: 2018, ), Wydawca: BITs
    Data:
    konferencja 26-28.03.2018
    Status:
    Published
  3. Conformational insights of Lysozyme adsorption onto gold surface – an important factor in Alzheimer's disease diagnostics
    Authors:
    P. Komorek, M. Wałek, B. Jachimska
    Conference:
    2nd Wroclaw Scientific Meetings (rok: 2018, ), Wydawca: Wydawnictwi naukowe Tygiel
    Data:
    konferencja 02.03.2018
    Status:
    Published
  4. Optimal conditions for efficient formation of PAMAM dendrimers complexes with 5-fluorouracil
    Authors:
    M. Szota, J. Mooney, B. Jachimska
    Conference:
    4th International Wroclaw Scientific Meeting, Wroclaw (online) (rok: 2020, ), Wydawca: Wydawnictwo Naukowe Tygiel
    Data:
    konferencja 44113
    Status:
    Published
  5. Physicochemical characterization of poly-L-lysine and its interactions with globular proteins
    Authors:
    P. Komorek, R. Stokłosa, B. Jachimska
    Conference:
    Zjazd Zimowy Sekcji Studenckiej Polskiego Towarzystwa Chemicznego (rok: 2018, ), Wydawca: Politechnika Warszawska
    Data:
    konferencja 08.12.2018
    Status:
    Published
  6. Changes in protein's II-structure as a result of its interactions with a gold surface – favorable conditions for aggregates formation
    Authors:
    P. Komorek, E. Martin, M. Wałek, I. Brand, B. Jachimska
    Conference:
    VII Sympozjum Doktorantów Chemii (rok: 2019, ), Wydawca: Uniwersytet Łódzki
    Data:
    konferencja 09-10.05.2019
    Status:
    Published
  7. PAMAM dendrimers as effective 5-Fluorouracil delivery systems"
    Authors:
    M. Szota, K. Reczyńska, E. Pamuła, O. Michel, J. Kulbacka, B. Jachimska
    Conference:
    II Sympozjum Biomateriały w Medycynie i Kosmetologii (rok: 2021, ), Wydawca: Uniwersytet im. Mikołaja Kopernika w Toruniu
    Data:
    konferencja 28.01.2021
    Status:
    Published
  8. Physicochemical Characterization Of Poly-L-Lysine and Its Interactions With Globular Proteins
    Authors:
    P. Komorek, R. Stokłosa, J. Zemła, M. Lekka, B Jachimska
    Conference:
    Fifth Edition of International Conference on Analytical and Nanoanalytical Methods for Biomedical and Environmental Sciences, "IC-ANMBES 2018" (rok: 2018, ), Wydawca: Transilvania University Press
    Data:
    konferencja 23-25.05.2018
    Status:
    Published
  9. β-Lactoglobulin as a platform for designing biologically active carriers: simulation and experiment
    Authors:
    G. Turner, S. Świątek, P. Komorek, B. Jachimska
    Conference:
    2nd Wroclaw Scientific Meetings (rok: 2018, ), Wydawca: Wydawnictwo naukowe Tygiel
    Data:
    konferencja 02.03.2018
    Status:
    Published
  10. Development of dendrimer based drug delivery system
    Authors:
    B.Jachimska
    Conference:
    Surface Modification for Chemical and Biochemical Sensing (rok: 2019, ), Wydawca: Institute of Physical Chemistry PAS
    Data:
    konferencja 08-12.11.2019
    Status:
    Published
  11. PAMAM dendrimers as nanocarriers for 5-fluorouracil: effectiveness of complex formation and cytotoxicity studies
    Authors:
    M. Szota, K. Reczyńska, E. Pamuła, O. Michel, J. Kulbacka, B. Jachimska
    Conference:
    Spring 2021 American Chemical Society National Meeting (rok: 2021, ), Wydawca: ACS
    Data:
    konferencja 05-16.04.2021
    Status:
    Published
  12. Physicochemical characterisation of PAMAM dendrimer as a multifunctional nanocarriers"
    Authors:
    B. Jachimska
    Conference:
    International Workshop on Polyelectrolytes in Chemistry, Biology and Technology 2018, (rok: 2018, ), Wydawca: Nanyang Technological University Singapore
    Data:
    konferencja 12-14.03.2018
    Status:
    Published
  13. Physicochemical characterisation of PAMAM dendrimer as multifunctional nanocarriers
    Authors:
    B.Jachimska
    Conference:
    Spring 2019 American Chemical Society National Meeting Orlando (rok: 2019, ), Wydawca: ACS
    Data:
    konferencja 28.03-03.04.2019
    Status:
    Published
  14. Poly(amidoamine) dendrimers as nanocarriers for anticancer drugs and their interactions with plasma proteins
    Authors:
    M. Szota, K. Reczyńska, E. Pamuła, O. Michel, J. Kulbacka, B. Jachimska
    Conference:
    INTERFACES INTERNATIONAL CONFERENCE From new materials to life science – Structure, Interactions, Dynamics and Activity, University of Cagliari (rok: 2021, ), Wydawca: University of Cagliari
    Data:
    konferencja 21-25.09.2021
    Status:
    Published
  15. Self-Assembling Behavior of Biopolyelectrolytes
    Authors:
    P. Komorek, S. Swiatek, K. Tokarczyk, B. Jachimska
    Conference:
    International Workshop on Polyelectrolytes in Chemistry, Biology and Technology 2018 (rok: 2018, ), Wydawca: Nanyang Technological University Singapore
    Data:
    konferencja 12-14.03.2018
    Status:
    Published
  16. Changes in lysozyme's II-structure as a result of its interaction with a gold surface – a crucial step for Alzheimer's disease mystery solving
    Authors:
    P. Komorek, E. Martin, M. Wałek, I. Brand, B. Jachimska
    Conference:
    Fifth Edition of International Conference on Analytical and Nanoanalytical Methods for Biomedical and Environmental Sciences, "IC-ANMBES 2018 (rok: 2018, ), Wydawca: Transilvania University Press
    Data:
    konferencja 23-25.05.2018
    Status:
    Published
  17. Changes in Lysozyme's II-Structure and Aggregates Formation as a Result of Its Interactions with a Gold Surface
    Authors:
    P. Komorek, E. Martin, I. Brand, B. Jachimska
    Conference:
    The FEBS Congress (rok: 2019, ), Wydawca: FEBS Open Bio
    Data:
    konferencja 06-11.07.2019
    Status:
    Published
  18. Conformational stability of lysozyme adsorbed onto gold surfaces
    Authors:
    P. Komorek, E. Martin, M. Wałek, I. Brand, B. Jachimska
    Conference:
    International Conference on Catalysis and Surface Chemistry 2018 & 50-te OKK (rok: 2018, ), Wydawca: IKiFP PAN
    Data:
    konferencja 18-23.03.2018
    Status:
    Published
  19. Lactoglobulin as a platform for designing biologically active carriers
    Authors:
    B.Jachimska, S. Swiatek
    Conference:
    25th International Symposium on Bioelectrochemistry and Bioenergetics of the Bioelectrochemical Society (rok: 2019, ), Wydawca: Uniwersytet Limerick
    Data:
    konferencja 26.05.-30.05.2019
    Status:
    Published
  20. Self-Assembling Behavior of Proteins: Effect of the Interaction between Protein and Surface
    Authors:
    B. Jachimska, K. Tokarczyk, K.Kubiak-Ossowska, P. Komorek, S.Swiatek, P. Mulheran
    Conference:
    22nd Topical ISE Meeting in Tokyo (rok: 2018, ), Wydawca: Waseda University
    Data:
    konferencja 15-18.04.2018
    Status:
    Published
  21. Bovine β-lactoglobulin as biomolecules carriers"
    Authors:
    S. Świątek, G. Turner, P. Komorek, B. Jachimska
    Conference:
    International Conference on Catalysis and Surface Chemistry 2018 & 50-te OKK, Kraków, (rok: 2018, ), Wydawca: IKiFP PAN
    Data:
    konferencja 18-23.03.2018
    Status:
    Published
  22. Changes in protein's secondary structure as a result of its interaction with a gold surface
    Authors:
    P. Komorek, E. Martin, M. Wałek, I. Brand, B. Jachimska
    Conference:
    Spring 2019 American Chemical Society National Meeting Orlando (rok: 2019, ), Wydawca: ACS
    Data:
    konferencja 28.03-03.04.2019
    Status:
    Published
  23. Corona Formation and Conformational Changes in Proteins on Dendrimers
    Authors:
    B. Jachimska, M. Szota, K. Rakowski
    Conference:
    XXVIth International Symposium on Bioelectrochemistry and Bioenergetics of the Bioelectrochemical Society 2021 (rok: 2021, ), Wydawca: BES
    Data:
    konferencja 09-13.05.2021
    Status:
    Published
  24. Effect of the surface charge on the structure of lysozyme adsorbed on the gold surface
    Authors:
    P. Komorek, I. Brand, B. Jachimska
    Conference:
    4th International Wroclaw Scientific Meeting, Wroclaw (online) (rok: 2020, ), Wydawca: Wydawnictwo Naukowe Tygiel
    Data:
    konferencja 44113
    Status:
    Published
  25. Orientacja, konformacja oraz hydratacja lizozymu na powierzchni Au
    Authors:
    P. Komorek, M. Wałek, B. Jachimska
    Conference:
    E-zjazd Zimowy Sekcji Studenckiej Polskiego Towarzystwa Chemicznego, Warszawa (rok: 2020, ), Wydawca: PTCH
    Data:
    konferencja 15.12.2020
    Status:
    Published
  26. Physicochemical and structural characterization of poly-L-lysine (PLL) monolayers on gold surface
    Authors:
    B. Jachimska, P. Komorek, R. Stokłosa
    Conference:
    International Workshop on Polyelectrolytes in Chemistry, Biology and Technology 2018 (rok: 2018, ), Wydawca: Nanyang Technological University Singapure
    Data:
    konferencja 12-14.03.2018
    Status:
    Published
  27. Structure and Function of Protein Corona on the Dendrimer Surface
    Authors:
    B. Jachimska, M. Szota, K. Rakowski
    Conference:
    Spring 2021 American Chemical Society National Meeting (on-line) (rok: 2021, ), Wydawca: ACS
    Data:
    konferencja 05-16.04.2021
    Status:
    Published
  28. Wpływ procesu adsorpcji lizozymu na orientację, konformację oraz hydratację uzyskanych warstw białkowych
    Authors:
    P. Komorek, M. Wałek, I. Brand, B. Jachimska
    Conference:
    Sympozjum Młodych Naukowców Wydziału Fizyki UW (rok: 2020, ), Wydawca: Uniwersytet Warszawski
    Data:
    konferencja 24-27.08.2020
    Status:
    Published
  29. Protein corona formation: impact on nanoparticles bio-behavior
    Authors:
    B. Jachimska, M. Szota, J. Rea, K. Rakowski
    Conference:
    10th International Workshop on Surface Modification for Chemical and Biochemical Sensing – SMCBS'2021 (rok: 2021, ), Wydawca: Instytut Chemii Fizycznej PAN
    Data:
    konferencja 05-09-11.2021
    Status:
    Submitted
  1. Physicochemical characterisation of PAMAM dendrimer as a multifunctional nanocarriers
    Authors:
    B. Jachimska
    Book:
    Nanoparticles in Pharmacotherapy (rok: 2019, tom: 3, strony: 45315), Wydawca: Elsevier
    Status:
    Published

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