Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Molecular picture of the mechanochemical coupling in ATP synthase as a conceptual framework for the development of novel antimicrobial drugs

2017/26/E/NZ2/00472

Keywords:

ATP synthase motor proteins mechanochemistry molecular dynamics structure-guided drug design

Descriptors:

  • NZ2_10:
  • ST4_15:
  • NZ1_3:

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Politechnika Gdańska, Wydział Chemiczny

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Jacek Czub 

Number of co-investigators in the project: 10

Call: SONATA BIS 7 - announced on 2017-06-14

Amount awarded: 1 597 600 PLN

Project start date (Y-m-d): 2018-04-09

Project end date (Y-m-d): 2024-10-08

Project duration:: 78 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Molecular mechanism and energetics of coupling between substrate binding and product release in the F1-ATPase catalytic cycle
    Authors:
    Michał Badocha, Miłosz Wieczór, Antoni Marciniak, Cyprian Kleist, Helmut Grubmüller, Jacek Czub
    Academic press:
    Proceedings of the National Academy of Sciences USA (rok: 2023, tom: 120, strony: e2215650120), Wydawca: National Academy of Sciences
    Status:
    Published
    DOI:
    10.1073/pnas.2215650120 - link to the publication
  2. Determinants of Directionality and Efficiency of the ATP Synthase Fo Motor at Atomic Resolution 2022, 13, XXX, 387–392
    Authors:
    A. Marciniak, P. Chodnicki, K.A. Hossain, J. Slabonska, J. Czub,
    Academic press:
    J. Phys. Chem. Lett. (rok: 2022, tom: 13, strony: 387--392), Wydawca: American Chemical Socisty
    Status:
    Published
    DOI:
    10.1021/acs.jpclett.1c03358 - link to the publication
  3. Low-Barrier Hydrogen Bond Determines Target-Binding Affinity and Specificity of the Antitubercular Drug Bedaquiline
    Authors:
    Joanna Słabońska, Subrahmanyam Sappati, Antoni Marciniak, Jacek Czub
    Academic press:
    ACS Medicinal Chemistry Letters (rok: 2024, tom: 15, strony: 265–269), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acsmedchemlett.3c00509 - link to the publication

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