Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Structural studies of signaling receptors HVEM/CD160 as potential targets for immunoterapy against melanoma

2016/21/D/NZ1/02777

Keywords:

cancer melanoma immunotherapy against melanoma immune system regulation signaling receptors protein crystal structure structure-based drug design

Descriptors:

  • NZ1_4: Structural biology
  • NZ1_1: Molecular biology
  • NZ1_5: Genetic engineering

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Gdański, Wydział Chemii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marta Orlikowska 

Number of co-investigators in the project: 2

Call: SONATA 11 - announced on 2016-03-15

Amount awarded: 844 500 PLN

Project start date (Y-m-d): 2017-03-17

Project end date (Y-m-d): 2022-03-16

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer ze stacją graficzną (10 000 PLN)
  2. Mikroskop stereoskopowy z kamerą i przystawką polaryzacyjną (45 000 PLN)
  3. Szafa krystalizacyjna (inkubator do płytek krystalizacyjnych z kontrolą temperatury).
  4. Chłodziarka AGD.
  5. Autoklaw (20 000 PLN)
  6. Zamrażarka do -80 st.C (45 000 PLN)
  7. Spektrofotometr.
  8. Spektrofotometr - nanodrop (42 000 PLN)
  9. Chłodziarka laboratoryjna dwudrzwiowa.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (2)
  1. Expression, purification, and efficient refolding of the extracellular domain of Escherichia coli-expressed signaling receptor Herpesvirus entry mediator (HVEM)
    Authors:
    Marta Szymczak, Szymon Ziętkiewicz, Katarzyna Kuncewicz, Sylwia Rodziewicz-Motowidło, Marta Orlikowska
    Academic press:
    Protein Expression and Purification (rok: 2019, tom: 164, strony: 105450), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.pep.2019.105450 - link to the publication
  2. Interplay between DsbA1, DsbA2 and C8J_1298 Periplasmic Oxidoreductases of Campylobacter jejuni and Their Impact on Bacterial Physiology and Pathogenesis
    Authors:
    Anna M Banaś, Katarzyna M Bocian-Ostrzycka, Stanisław Dunin-Horkawicz, Jan Ludwiczak, Piotr Wilk, Marta Orlikowska, Agnieszka Wyszyńska, Maria Dąbrowska, Maciej Plichta, Marta Spodzieja, Marta A Polańska, Agata Malinowska, Elżbieta Katarzyna Jagusztyn-Krynicka
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22 (24), strony: 13451), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222413451 - link to the publication
  3. CD160 protein as a new therapeutic target in a battle against autoimmune, infectious and lifestyle diseases. Analysis of the structure, interactions and functions
    Authors:
    Marta Piotrowska, Marta Spodzieja, Katarzyna Kuncewicz, Sylwia Rodziewicz-Motowidło, Marta Orlikowska
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2021, tom: 224, strony: 113694), Wydawca: ScienceDirect
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2021.113694 - link to the publication
  1. Expression and purification of signaling receptors HVEM/CD160 as potential targets for immunotherapy against melanoma
    Authors:
    Orlikowska Marta, Ziętkiewicz Szymon, Liberek Krzysztof, Rodziewicz-Motowidło Sylwia
    Conference:
    24 Polish Peptide Symposium (rok: 2017, ), Wydawca: Uniwersytet Gdański
    Data:
    konferencja 3-7.09
    Status:
    Published
  2. Receptory sygnałowe HVEM/CD160 jako potencjalne cele terapii przeciw czerniakowi
    Authors:
    Szymczak Marta, Orlikowska Marta, Rodziewicz-Motowidło Sylwia
    Conference:
    ZJAZD ZIMOWY SEKCJI STUDENCKIEJ POLSKIEGO TOWARZYSTWA CHEMICZNEGO (rok: 2017, ), Wydawca: Collegium Medicum UMK
    Data:
    konferencja 8-9.12
    Status:
    Published