Projects search

Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation

Authors:

Smietanski M., Werner M., Purta E., Kaminska K.H., Stepinski J., Darzynkiewicz E., Nowotny M., Bujnicki J.M.

Academic press:

Nature Communications (year: 2014, volume: 5, pages: 46032), Publisher: Macmillan Publishers Limited

Status:

Published

DOI:

10.1038/ncomms4004 – link to the publication

Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versalite tools for manipulation of therapeutically relevant cap-dependent processes

Authors:

Kowalska J., Wypijewska del Nogal A., Darzynkiewicz Z.M., Buck J., Nicola C., Kuhn A.N., Lukaszewicz M., Zuberek J., Strenkowska M., Ziemniak M., Maciejczyk M., Bojarska E., Rhoads R.E., Darzynkiewicz E., Sahin U., Jemielity J.

Academic press:

Nucleic Acids Research (year: 2014, volume: 42, pages: 10245-10264), Publisher: Oxford University Press

Status:

Published

DOI:

10.1093/nar/gku757 – link to the publication

Triazole-containing monophosphate mRNA cap analogs as effective translation inhibitors

Authors:

Piecyk K., Lukaszewicz M., Darzynkiewicz E., Jankowska-Anyszka M.

Academic press:

RNA (year: 2014, volume: 20, pages: 1539-1547), Publisher: Cold Spring Harbor Laboratory Press

Status:

Published

DOI:

10.1261/rna.046193.114 – link to the publication

Effect of the His-Tag Location on Decapping Scavenger Enzymes and Their Hydrolytic Activity toward Cap Analogs

Authors:

Ferenc-Mrozek A., Bojarska E., Stepinski J., Darzynkiewicz E., Lukasiewicz M.

Academic press:

ACS Omega (year: 2020, volume: 5, pages: 10759-10766), Publisher: ACS Publications

Status:

Published

DOI:

10.1021/acsomega.0c00304 – link to the publication

Kinetic analysis of IFIT1 and IFIT5 interaction with different native and engineered RNAs and its consequences for designing mRNA-based therapeutics.

Authors:

Miedziak B., Dobiezynska A., Darzynkiewicz Z.M., Bartkowska J., Miszkiewicz J., Kowalska J., Warminski M., Tyras M., Trylska J., Jemielity J., Darzynkiewicz E., Grzela R.

Academic press:

RNA (year: 2020, volume: 26, pages: 58-68), Publisher: Cold Spring Harbor Laboratory Press

Status:

Published

DOI:

10.1261/rna/073304.119 – link to the publication

Molecular recognition of mRNA 5' cap by 3' poly(A)-specific ribonuclease (PARN) differs from interactions known for other cap-binding proteins

Authors:

Niedzwiecka A., Nilsson P., Worch R., Stepinski J., Darzynkiewicz E., Virtanen A.

Academic press:

Biochimica at Biophysica Acta - Proteins and Proteomics (year: 2016, volume: 1864, pages: 331-345), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.bbapap.2016.01.002 – link to the publication

eIF4E-like complexes formed by cap-binding homolog TbEIF4E5 with TbEIF4G1 or TbEIF4G2 are implicated in post-transcriptional regulation in Trypanosoma brucei

Authors:

Freire E.R., Vashisht A.A., Malvezzi A.M., Zuberek J., Langousis G., Saada E.A., Nascimento J. DE F., Stepinski J., Darzynkiewicz E., Hill K., De Melo Neto O.P., Wohlschlegel J.A., Sturm N.R., Campbell D.A.

Academic press:

RNA (year: 2014, volume: 20, pages: 1272-1286), Publisher: Cold Spring Harbor Laboratory Press

Status:

Published

DOI:

10.1261/rna.045534.114 – link to the publication

Decapping Scavenger (DcpS) enzyme: Advences in its structure, activity and roles in the cap-dependent mRNA metabolism

Authors:

Milac A.L., Bojarska E., Wypijewska del Nogal A.

Academic press:

Biochimica at Biophysica Acta - Gene Regulatory Mechanism (year: 2014, volume: 1839, pages: 452-462), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.bbagrm.2014.04.007 – link to the publication

Helix 69 of Escherichia coli 23S ribosomal RNA as a peptide nucleic acid target

Authors:

Kulik M., Markowska-Zagrajek A., Wojciechowska M., Grzela R., Witula T., Trylska J.

Academic press:

Biochimie (year: 2017, volume: 138, pages: 32-42), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.biochi.2017.04.001 – link to the publication

Quantum dots use both LUMO and surface trap electrons in photoreduction process

Authors:

Darzynkiewicz Z.M., Pedziwiatr M., Grzyb J.

Academic press:

Journal of Luminescence (year: 2017, volume: 183, pages: 401-409), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.jlumin.2016.11.070 – link to the publication

Amino-Functionalized 5' Cap Analogs as Tools for Site-Specific Sequence-Independent Labeling of mRNA

Authors:

Warminski M., Sikorski P.J., Warminska Z., Lukaszewicz M., Kropiwnicka A., Zuberek J., Darzynkiewicz E., Kowalska J., Jemielity J.

Academic press:

Bioconjugate Chemistry (year: 2017, volume: 28, pages: 1978-1992), Publisher: American Chemical Society

Status:

Published

DOI:

10.1021/acs.bioconjchem.7b00291 – link to the publication

Modified ARCA analogs providing enhanced translational properties of capped mRNAs

Authors:

Kocmik I., Piecyk K., Rudzinska M., Niedzwiecka A., Darzynkiewicz E., Grzela R., Jankowska-Anyszka M.

Academic press:

Cell Cycle (year: 2018, volume: 17, pages: 1624-1636), Publisher: Taylor & Francis

Status:

Published

DOI:

10.1080/15384101.2018.1486164 – link to the publication

Hydrolytic activity of human Nudt16 enzyme on dinucleotide cap analogs and short capped oligonucleotides

Authors:

Grzela R., Nasilowska K., Lukaszewicz M., Tyras M., Stepinski J., Jankowska-Anyszka M., Bojarska E., Darzynkiewicz E.

Academic press:

RNA (year: 2018, volume: 24, pages: 633-642), Publisher: Cold Spring Harbor Laboratory Press

Status:

Published

DOI:

10.1261/rna.065698.118 – link to the publication

Cap analgs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential

Authors:

Strenkowska M., Grzela R., Majewski M., Wnek K., Kowalska J., Lukaszewicz M., Zuberek J., Darzynkiewicz E., Kuhn A.N., Sahin U., Jemielity J.

Academic press:

Nucleic Acids Research (year: 2016, volume: 44, pages: 9578-9590), Publisher: Oxford University Press

Status:

Published

DOI:

10.1093/nar/gkw896 – link to the publication

Decapping Scavenger Enzyme Activity toward N2-substituted 5' end mRNA Cap Analogues

Authors:

Pietrow P., Ferenc-Mrozek A., Piecyk K., Bojarska E., Darzynkiewicz E., Jankowska-Anyszka M.

Academic press:

ACS Omega (year: 2019, volume: 4, pages: 17576-17580), Publisher: ACS Publications

Status:

Published

DOI:

10.1021/acsomega.9b02715 – link to the publication

Cap analogs containing 6-thioguanosine - reagents for the synthesis of mRNAs selectively photo-crosslinkable with cap-binding biomolecules

Authors:

Nowakowska M., Kowalska J., Martin F., d'Orchymont A., Zuberek J., Lukaszewicz M., Darzynkiewicz E., Jemielity J.

Academic press:

Organic & Biomolecular Chemistry (year: 2014, volume: 12, pages: 4841-4847), Publisher: Royal Society of Chemistry

Status:

Published

DOI:

10.1039/c4ob00059e – link to the publication

Effect of different N7 substitution of dinucleotide cap analogs on the hydrolytic susceptibility towards scavenger decapping enzymes (DcpS)

Authors:

Piecyk K., Darzynkiewicz Z.M., Jankowska-Anyszka M., Ferenc-Mrozek A., Stepinski J., Darzynkiewicz E., Bojarska E.

Academic press:

Biochemical and Biophysical Research Communications (year: 2015, volume: 464, pages: 89-93), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.bbrc.2015.06.001 – link to the publication

Clickable trimethylguanosine cap analogs modified within the triphosphate bridge: synthesis, conjugation to RNA and susceptibility to degradation

Authors:

Wojtczak B.A., Warminski M., Kowalska J., Lukaszewicz M., Honcharenko M., Smith C.I.E., Stromberg R., Darzynkiewicz E., Jemielity J.

Academic press:

RCS Advances (year: 2016, volume: 6, pages: 8317-8328), Publisher: Royal Society of Chemistry

Status:

Published

DOI:

10.1039/c5ra25684d – link to the publication

Phosphate-modified analogues of m7GTP and m7Gppppm7G - Synthesis and biochemical properties

Authors:

Ziemniak M., Kowalska J., Lukaszewicz M., Zuberek J., Wnek K., Darzynkiewicz E., Jemielity J.

Academic press:

Bioorganic & Medicinal Chemistry (year: 2015, volume: 23, pages: 5369-5381), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.bmc.2015.07.052 – link to the publication

mRNA and snRNA Cap Analogs: Synthesis and Applications

Authors:

Stepinski J., Darzynkiewicz E.

Book:

Chemical Biology of Nucleic Acids - Fundamentals and Clinical Applications, RNA Technologies (year: 2014, volume: 28, pages: 511-561), Publisher: Springer-Verlag

Status:

Published