Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Novel broad-spectrum central nervous system active substances: optimization of their multi-target profile

2021/43/B/NZ7/01732

Keywords:

central nervous system diseases neurodegenerative diseases computer-assisted drug design caspases kinases multi-target drugs G protein-coupled receptors

Descriptors:

  • NZ7_014:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Anna Kaczor 

Number of co-investigators in the project: 11

Call: OPUS 22 - announced on 2021-09-15

Amount awarded: 1 944 680 PLN

Project start date (Y-m-d): 2022-08-01

Project end date (Y-m-d): 2025-07-31

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  1. Novel multi-target ligands of dopamine and serotonin receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds-synthesis, biological activity, and structural evaluation
    Authors:
    Piotr Stępnicki, Olga Wronikowska-Denysiuk, Agata Zięba, Katarzyna M. Targowska-Duda, Agata Bartyzel, Martyna Z. Wróbel, Tomasz M. Wróbel, Klaudia Szałaj, Andrzej Chodkowski, Karolina Mirecka, Barbara Budzyńska, Emilia Fornal, Jadwiga Turło, Marián Castro, Agnieszka A. Kaczor
    Academic press:
    Journal of Enzyme Inhibition and Medicinal Chemistry (rok: 2023, tom: 38, strony: 2209828), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/14756366.2023.2209828 - link to the publication
  2. Caspases in Alzheimer's Disease: Mechanism of Activation, Role, and Potential Treatment
    Authors:
    Piotr Wójcik, Michał K. Jastrzębski, Agata Zięba, Dariusz Matosiuk, Agnieszka A. Kaczor
    Academic press:
    Molecular Neurobiology (rok: 2023, tom: Online ahead of print, strony: Online ahead of print), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-023-03847-1 - link to the publication
  3. Effects of small molecules on neurogenesis: Neuronal proliferation and differentiation
    Authors:
    Michał Jastrzębski, Piotr Wójcik, Piotr Stępnicki, Agnieszka A. Kaczor
    Academic press:
    Acta Pharmaceutica Sinica (rok: 2023, tom: 14, strony: 20-37), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.007 - link to the publication
  4. Funnel metadynamics and behavioral studies reveal complex effect of D2AAK1 ligand on anxiety‑like processes
    Authors:
    Damian Bartuzi, Ewa Kędzierska, Katarzyna M. Targowska-Duda, Oliwia Koszła, Tomasz M. Wróbel, Simon Jademyr, Tadeusz Karcz, Katarzyna Szczepańska, Piotr Stępnicki, Olga Wronikowska-Denysiuk, Grażyna Biała, Jadwiga Handzlik, Jesper L Kristensen, Antti Poso, Agnieszka A. Kaczor
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: 21192), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-022-25478-7 - link to the publication
  5. Novel multi-target ligands of dopamine and serotonin receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds-synthesis, biological activity, and structural evaluation
    Authors:
    Piotr Stępnicki, Olga Wronikowska-Denysiuk, Agata Zięba, Katarzyna M. Targowska-Duda, Agata Bartyzel, Martyna Z. Wróbel, Tomasz M. Wróbel, Klaudia Szałaj, Andrzej Chodkowski, Karolina Mirecka, Barbara Budzyńska, Emilia Fornal, Jadwiga Turło, Marián Castro, Agnieszka A. Kaczor
    Academic press:
    Journal of Enzyme Inhibition and Medicinal Chemistry (rok: 2023, tom: 38, strony: 2209828), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/14756366.2023.2209828 - link to the publication
  6. Funnel metadynamics and behavioral studies reveal complex effect of D2AAK1 ligand on anxiety‑like processes
    Authors:
    Damian Bartuzi, Ewa Kędzierska, Katarzyna M. Targowska-Duda, Oliwia Koszła, Tomasz M. Wróbel, Simon Jademyr, Tadeusz Karcz, Katarzyna Szczepańska, Piotr Stępnicki, Olga Wronikowska-Denysiuk, Grażyna Biała, Jadwiga Handzlik, Jesper L Kristensen, Antti Poso, Agnieszka A. Kaczor
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: 21192), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-022-25478-7 - link to the publication
  7. Caspases in Alzheimer's Disease: Mechanism of Activation, Role, and Potential Treatment
    Authors:
    Piotr Wójcik, Michał K. Jastrzębski, Agata Zięba, Dariusz Matosiuk, Agnieszka A. Kaczor
    Academic press:
    Molecular Neurobiology (rok: 2023, tom: Online ahead of print, strony: Online ahead of print), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-023-03847-1 - link to the publication

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