Projects funded by the NCN
Targeted inhibition of hypusination pathway
2022/47/B/NZ7/01667
Keywords:
hypusination eIF5A fragment screening protein crystallography structure-based drug design
Descriptors:
- NZ7_014:
- NZ1_004:
- NZ1_002:
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego
woj. małopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 5
Call: OPUS 24 - announced on 2022-07-15
Amount awarded: 2 999 196 PLN
Project start date (Y-m-d): 2023-06-20
Project end date (Y-m-d): 2027-08-19
Project duration:: 50 months (the same as in the proposal)
Project status: Pending project
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- ERK1/2 interaction with DHPS regulates eIF5A deoxyhypusination independently of ERK kinase activityAuthors:Andrew E. Becker, Paweł Kochanowski, Pui-Kei Wu, Elżbieta Wątor, Wenjing Chen, Koushik Guchhait, Artur P. Biela, Przemysław Grudnik, Jong-In ParkAcademic press:Cell Reports (rok: 2024, tom: 43, strony: 114831), Wydawca: Cell PressStatus:PublishedDOI:10.1016/j.celrep.2024.114831 - link to the publication