Projects funded by the NCN


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72 projects found matching your search criteria :

  1. Assessment of the state and function of the brain cholinergic system in animal models of Alzheimer-type and frontotempor...

    Call: OPUS 8 , Panel: NZ4

    Principal investigator: dr hab. Grażyna Niewiadomska

    Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

  2. Search for early molecular mechanisms and markers of preclinical stage of sporadic form of Alzheimer's disease (SAD) in ...

    Call: SONATA 8 , Panel: NZ4

    Principal investigator: dr Anna Mietelska-Porowska

    Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

  3. The role of bioactive sphingolipids: ceramide, ceramide-1-phosphate and sphingosine-1-phosphate in regulation of mitocho...

    Call: OPUS 8 , Panel: NZ3

    Principal investigator: dr hab. Robert Strosznajder

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  4. Approach to structures of difficult protein targets using new mass spectrometry-based methods

    Call: MAESTRO 6 , Panel: NZ1

    Principal investigator: prof. Michał Dadlez

    Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

  5. The influence of nanoparticles on beta-amyloid removal by microglia cells

    Call: PRELUDIUM 6 , Panel: NZ7

    Principal investigator: Katarzyna Sikorska

    Instytut Chemii i Techniki Jądrowej

  6. Proteomic analysis of changes in brain and liver mitochondria in apoE-knockout mice – influence of metformin – an AMP-ac...

    Call: PRELUDIUM 1 , Panel: NZ2

    Principal investigator: dr Maciej Suski

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Lekarski

  7. Inhibitors of ER stress dependant PERK kinase as a novel approach for Alzheimer's therapy

    Call: HARMONIA 5 , Panel: NZ1

    Principal investigator: prof. Ireneusz Majsterek

    Uniwersytet Medyczny w Łodzi, Wydział Wojskowo-Lekarski

  8. Conjugates of prion protein with dendrimers as inhibitors of Abeta peptide amyloidogenesis and cytotoxicity of potential...

    Call: HARMONIA 5 , Panel: NZ4

    Principal investigator: dr hab. Krzysztof Nieznański

    Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

  9. Searching for biological functions of APP family of proteins and APP-derived fragments in olfactory system.

    Call: OPUS 5 , Panel: NZ3

    Principal investigator: dr hab. Rafał Butowt

    Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

  10. The influence of dimethyl fumarate on the spatial memory, neurogenesis, neurodegeneration and cerebral imflammation in t...

    Call: SONATA 5 , Panel: NZ4

    Principal investigator: dr Irena Majkutewicz

    Uniwersytet Gdański, Wydział Biologii

  11. Structural investigation of the active center of gamma-secretase and its interactions with selected substrates.

    Call: PRELUDIUM 5 , Panel: NZ2

    Principal investigator: Krzysztof Młynarczyk

    Uniwersytet Warszawski, Wydział Chemii

  12. FUNCTIONAL STUDIES OF RARE GENETIC VARIANTS OF GENES CAUSSALLY CONNECTED WITH ALZHEIMER'S DISEASE IN THE POLISH POPULATI...

    Call: SONATA 5 , Panel: NZ3

    Principal investigator: dr Michalina Wężyk

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  13. The role of poly(ADP-ribose) polymerase and sirtuins in molecular mechanism of cell death. Identification of novel targe...

    Call: OPUS 5 , Panel: NZ3

    Principal investigator: prof. Joanna Strosznajder

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  14. Looking for the same pathological factors in ischemic brain and Alzheimer's disease;Genes

    Call: OPUS 5 , Panel: NZ7

    Principal investigator: prof. Ryszard Pluta

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  15. Synthetic cysteine peptides as molecular layers for studies of interactions between copper ions and beta-amyloid

    Call: SONATA 4 , Panel: ST4

    Principal investigator: dr Urszula Wawrzyniak

    Politechnika Warszawska, Wydział Chemiczny

  16. Determination of physicochemical and biochemical propertiess of natural pyridine and piperidine alkaloids and their simp...

    Call: PRELUDIUM 4 , Panel: NZ7

    Principal investigator: dr Damian Szczesny

    Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

  17. Search of novel multifunctional ligands targeting neurodegereneration processes.

    Call: OPUS 4 , Panel: NZ7

    Principal investigator: prof. Barbara Malawska

    Uniwersytet Jagielloński-Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  18. Functional, epigenetic and genetic aspects of base excision repair pathway in Alzheimer's disease

    Call: OPUS 3 , Panel: NZ7

    Principal investigator: dr hab. Tomasz Śliwiński

    UNIWERSYTET ŁÓDZKI, Wydział Biologii i Ochrony Środowiska

  19. The role of acquired channelopathies in facilitationg post-traumatic epileptogenesis in APP/PS1 transgenic mice - an ani...

    Call: PRELUDIUM 3 , Panel: NZ4

    Principal investigator: Diana Miszczuk

    Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

  20. An attempt to elucidate the role of clusterin and lipid rafts in Alzheimer's disease etiology.

    Call: OPUS 2 , Panel: NZ7

    Principal investigator: prof. Arkadiusz Orzechowski

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  21. Effect of phosphorylation of Aβ peptides on the redox activity oftheir copper complexes and aggregation in the context o...

    Call: SONATA 19 , Panel: ST4

    Principal investigator: dr Nina Wezynfeld

    Politechnika Warszawska, Wydział Chemiczny

  22. Synthesis and biological activity evaluation of new hybrid derivatives of tacrine and melatonin as potential cholinester...

    Call: OPUS 2 , Panel: ST5

    Principal investigator: dr Anna Zawadzka

    Uniwersytet Warszawski, Wydział Chemii

  23. Blood plasma microRNA profile as a basis for detecting Alzheimer's disease and dementia risk in pre-symptomatic individu...

    Call: OPUS 24 , Panel: NZ7

    Principal investigator: prof. Urszula Wojda

    Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

  24. Study of the regenerative potential of Stem Cells from Human Exfoliated Deciduous teeth (SHED) in Alzheimer's disease

    Call: POLONEZ BIS 3 , Panel: NZ3

    Principal investigator: dr Leila Elyasi

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  25. The role of CDK5 in inflammatory reaction in experimental model of Alzheimer's disease

    Call: OPUS 2 , Panel: NZ3

    Principal investigator: dr hab. Grzegorz Czapski

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  26. Selective modulation of PPARγ signaling as a new therapeutic strategy for Alzheimer's disease

    Call: PRELUDIUM 21 , Panel: NZ7

    Principal investigator: Karolina Przepiórska

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  27. Combination of FAAH inhibition with action via serotonin 5-HT6 receptor as pioneering approach to fight with Alzheimer D...

    Call: PRELUDIUM 21 , Panel: NZ7

    Principal investigator: Kinga Czarnota-Łydka

    Uniwersytet Jagielloński, Collegium Medicum

  28. Effects of activation of cholinergic, noradrenergic, and serotonergic systems on respiratory impairment in Alzheimer's d...

    Call: OPUS 23 , Panel: NZ7

    Principal investigator: dr hab. Katarzyna Kaczyńska

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  29. Development of the knowledge on the role of GPR18 ligands as a microglia-targeted strategy in the regulation of neuroinf...

    Call: SONATA 17 , Panel: NZ3

    Principal investigator: dr Ewelina Honkisz-Orzechowska

    Uniwersytet Jagielloński, Collegium Medicum

  30. Bleomycin hydrolase, homocysteine metabolism, epigenetic regulation of mTOR signalling, autophagy, and Alzheimer's disea...

    Call: OPUS 22 , Panel: NZ4

    Principal investigator: prof. Hieronim Jakubowski

    Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa, Ogrodnictwa i Bioinżynierii

  31. New approach to the treatment of Alzheimer's disease targetingresolution of inflammation and modulation of biomechanical...

    Call: OPUS 22 , Panel: NZ4

    Principal investigator: prof. Agnieszka Basta-Kaim

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  32. Research of multifunctional compounds targeting neuroinflammation and cholinergic deficit in Alzheimer's disease

    Call: OPUS 22 (LAP) , Panel: NZ7

    Principal investigator: prof. Kinga Sałat

    Uniwersytet Jagielloński, Collegium Medicum

  33. Role of Amyloid Precursor Protein in the regulation of store-operated calcium entry

    Call: OPUS 2 , Panel: NZ3

    Principal investigator: dr Tomasz Węgierski

    Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

  34. Potential neuroprotective properties of modulators of sphingosine-1-phosphate (S1P) receptors (fingolimod and siponimod)...

    Call: PRELUDIUM 20 , Panel: NZ5

    Principal investigator: Iga Wieczorek

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  35. Selective inhibitors of γ-aminobutyric acid (GABA) transporter subtype 3 (GAT3) as a new pharmacological tools and a cha...

    Call: OPUS 21 , Panel: NZ7

    Principal investigator: dr Dawid Panek

    Uniwersytet Jagielloński, Collegium Medicum

  36. Spectroelectrochemistry of Alzheimer's disease - a study of a new potential therapeutic molecule

    Call: SONATINA 5 , Panel: ST4

    Principal investigator: dr Magdalena Wiloch

    Instytut Chemii Fizycznej Polskiej Akademii Nauk

  37. Selective activation of non-nuclear Estrogen Receptor signaling with PaPE-1 as a novel therapeutic approach for sporadic...

    Call: OPUS 20 , Panel: NZ7

    Principal investigator: prof. Małgorzata Kajta

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  38. Direct monitoring of the local dynamic rearrangement of the Alzheimer's peptides secondary structure upon the aggregatio...

    Call: OPUS 19 , Panel: ST4

    Principal investigator: dr hab. Ewelina Lipiec

    Uniwersytet Jagielloński, Wydział Fizyki, Astronomii i Informatyki Stosowanej

  39. Deficits of spontaneous retrieval in older individuals with periodontitis: search for early cognitive dementia markers

    Call: PRELUDIUM 19 , Panel: HS6

    Principal investigator: Michał Wereszczyński

    Uniwersytet Jagielloński, Wydział Filozoficzny

  40. New multifunctional drug-like ligands focusing on molecular targets associated with the symptoms and causes of Alzheimer...

    Call: PRELUDIUM 19 , Panel: NZ7

    Principal investigator: Anna Pasieka

    Uniwersytet Jagielloński, Collegium Medicum

  41. Towards innovative strategy for treatment of Alzheimer's Disease via dual inhibition of receptor 5-HT6 and kinase CDK5.

    Call: PRELUDIUM 19 , Panel: NZ7

    Principal investigator: Sylwia Sudoł

    Uniwersytet Jagielloński, Collegium Medicum

  42. Structural studies of the influence of selected surfactants on the amyloidogenic properties of various forms of beta pep...

    Call: ETIUDA 8 , Panel: ST4

    Principal investigator: Michalina Wilkowska

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Fizyki

  43. Novel role of peroxisome proliferator-activated receptor α in the regulationof amyloid β peptide metabolism and mitochon...

    Call: PRELUDIUM 18 , Panel: NZ4

    Principal investigator: Sylwia Wójtowicz

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  44. Effect of drugs, mitochondrial proteins and miRNA biomarkers of neurodegenerative diseases on dynamics and conversion of...

    Call: SONATA BIS 9 , Panel: ST4

    Principal investigator: dr hab. Sławomir Jakieła

    Szkoła Główna Gospodarstwa Wiejskiego w Warszawie

  45. Transgenic mice with elevated basal level of calcium ions in neurons as a model of aged-induced neurodegeneration of spo...

    Call: MAESTRO 1 , Panel: NZ3

    Principal investigator: prof. Jacek Kuźnicki

    Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

  46. Multitarget approach to break the vicious circle of tau pathology and neuroinflammation in Alzheimer's disease: developm...

    Call: SONATA BIS 9 , Panel: NZ7

    Principal investigator: dr hab. Anna Więckowska

    Uniwersytet Jagielloński, Collegium Medicum

  47. Executive attention, genetic risk of Alzheimer's disease and cingulate cortex: an EEG and fMRI study

    Call: PRELUDIUM 16 , Panel: HS6

    Principal investigator: Patrycja Dzianok

    Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

  48. The role of BET family proteins in microglia-dependent neurodegeneration; relevance to Alzheimer's disease

    Call: OPUS 16 , Panel: NZ4

    Principal investigator: dr hab. Grzegorz Czapski

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  49. Novel hybrid 5-HT6 serotonin receptor and SERT transporter ligands as a therapeutic perspective of behavioural and cogni...

    Call: SONATA 14 , Panel: NZ7

    Principal investigator: dr Agata Siwek

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  50. MicroRNAs in blood as biomarkers for Alzheimer's disease: molecular signature for personalized therapy

    Call: OPUS 15 , Panel: NZ7

    Principal investigator: prof. Urszula Wojda

    Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk