Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Search of novel multifunctional ligands targeting neurodegereneration processes.

2012/07/B/NZ7/04253

Keywords:

multifunctional ligands cholinesterases inhibiotrs beta-amyloid BACE-1 inhibiotrs molecular modeling Alzhemer's disease

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • ST5_16:
  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński-Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Barbara Malawska 

Number of co-investigators in the project: 8

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 988 600 PLN

Project start date (Y-m-d): 2013-07-11

Project end date (Y-m-d): 2016-07-10

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Spektrofluorymetr (180 000 PLN)
  2. Opłata licencyjna specjalistycznego oprogramowania pakietu Schroedinger.
  3. Klatka Barnes Maze (60 000 PLN)
  4. Próżniowa wyparka rotacyjna.
  5. Wieloprocesorowa stacja robocza wraz z monitorem i zasolaczem UPS.
  6. Aparat do chromatografii typu flash (200 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (5)
  1. Ligandy wielofunkcyjne – nowa strategia poszukiwania leku w terapii chorób o złożonej etiologii
    Authors:
    Wichur T., Malawska B.
    Academic press:
    Postępy Higieny I Medycyny Doświadczalnej (rok: 2015, tom: 69, strony: 1423-1434), Wydawca: Polska Akademia Nauk
    Status:
    Published
    DOI:
    brak - link to the publication
  2. Recent Development of Multifunctional Agents as Potential Drug Candidates for the Treatment of Alzheimer's Disease
    Authors:
    Natalia Guzior, Anna Więckowska, Dawid Panek and Barbara Malawska
    Academic press:
    Current Medicinal Chemistry (rok: 2015, tom: 22, Nr 3, strony: 373-404), Wydawca: BENTHAM SCIENCE
    Status:
    Published
    DOI:
    10.2174/0929867321666141106122628 - link to the publication
  3. Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo,
    Authors:
    Więckowska A., Więckowski K., Bajda M., Brus B., Sałat K., Czerwińska P., Gobec S., Filipek B., Malawska B.
    Academic press:
    Bioorganic Medicinal Chemistry (rok: 2015, tom: 23, strony: 2445-2457), Wydawca: Elsevier
    Status:
    Published
    DOI:
    brak - link to the publication
  4. Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation
    Authors:
    Dawid Panek, Anna Więckowska, Tomasz Wichur, Marek Bajda, Justyna Godyń, Jakub Jończyk, Kamil Mika, Jana Janockova, Ondrej Soukup, Damijan Knez, Jan Korabecny, Stanislav Gobec, Barbara Malawska
    Academic press:
    European Journal on Medicinal Chemistry (rok: 2017, tom: 125, strony: 676-695), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2016.09.078 - link to the publication
  5. Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta
    Authors:
    Michalina Hebda, Marek Bajda, Anna Więckowska, Natalia Szałaj, Anna Pasieka, Dawid Panek, Justyna Godyń, Tomasz Wichur, Damijan Knez, Stanislav Gobec and Barbara Malawska
    Academic press:
    Molecules (rok: 2016, tom: 21, 410, strony: 45314), Wydawca: Molecular Diversity Preservation International (MDPI) Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/molecules21040410 - link to the publication
  6. Therapeutic strategies for Alzheimer's disease in clinical trials
    Authors:
    Godyń J., Jończyk J., Panek D., Malawska B.
    Academic press:
    Pharmacological Reports (rok: 2016, tom: 68, strony: 127–138), Wydawca: Elsevier
    Status:
    Published
    DOI:
    brak - link to the publication
  7. Search for potential cholinesterase inhibitors from Zinc database by virtual screening method
    Authors:
    Bajda M., Panek D., Hebda M., Więckowska A., Guzior N., Malawska B.
    Academic press:
    Acta Poloniae Pharmaceutica - Drug Research (rok: 2015, tom: 72(4), strony: 737-745), Wydawca: Polskie Towarzystwo Farmaceutyczne
    Status:
    Published
    DOI:
    brak - link to the publication
  1. Design, synthesis and biological evaluation of novel hybrid derivatives of isoindoline-1,3-dione targeting cholinesterases and beta-secretase.
    Authors:
    T. Wichur, J. Godyń, D. Panek, A. Więckowska, J. Jończyk, M. Bajda, B. Malawska
    Conference:
    Frontiers in Medicinal Chemistry (rok: 2016, ), Wydawca: www.gdch.de/medchem2016
    Data:
    konferencja 13-16, 03
    Status:
    Published
  2. Design, synthesis and biological evaluation of novel piperazine derivatives with hydroxyethylamine pharmacophoric core as multifunctional ligands targeting cholinesterases and beta-secretase.
    Authors:
    D. Panek, J. Godyń, A. Więckowska, J. Jończyk, M. Bajda, B. Malawska
    Conference:
    Frontiers in Medicinal Chemistry, Bonn (rok: 2016, ), Wydawca: www.gdch.de/medchem2016
    Data:
    konferencja 13-16, 03
    Status:
    Published
  3. Ligandy wielofunkcyjne szansą na odkrycie leku w terapii choroby Alzheimera
    Authors:
    Malawska B., Więckowska A., Bajda M., Szałaj N., Panek D.
    Conference:
    II Sympozjum SZKOŁA CHEMII MEDYCZNEJ (rok: 2015, ), Wydawca: Uniwersytet Medyczny we Wrocławiu
    Data:
    konferencja 17 – 19. 06
    Status:
    Published
  4. Synthesis, molecular modelling and biological evaluation of novel heterodimeric, multifunctional ligands targeting cholinesterases and beta-amyloid
    Authors:
    Malawska B., Hebda M., Więckowska A., Bajda M., Jończyk J., Panek D., Szałaj N., Knez D., Gobec S.,
    Conference:
    18th SCI/RSC Medicinal Chemistry Symposium (rok: 2015, ), Wydawca: Royal Society of Chemistry
    Data:
    konferencja 13-16. 09
    Status:
    Published
  5. DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW MULTI-TARGET-DIRECTED LIGANDS AS POTENTIAL ANTI-ALZHEIMER'S AGENTS
    Authors:
    Panek D., Więckowska A., Jończyk J., Wichur T., Godyń J., Bajda M, Malawska B.
    Conference:
    5th Meeting of the Paul Ehrlich MedChem Euro-PhD Network (rok: 2015, ), Wydawca: Polskie Towarzystwo Chemii Medycznej
    Data:
    konferencja 3 – 5. 07
    Status:
    Published

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