Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Assessment of the state and function of the brain cholinergic system in animal models of Alzheimer-type and frontotemporal dementia-type tauopathy.

2014/15/B/NZ4/05041

Keywords:

cholinergic system tau protein neurodegeneration tauopathies Alzheimer's disease frontotemporal dementia and parkinsonism linked to chromosome 17,aging animal models

Descriptors:

  • NZ4_7: Neurophysiology
  • NZ4_9: Systems neurobiology
  • NZ4_5: Anatomical pathology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Grażyna Niewiadomska 

Number of co-investigators in the project: 4

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 596 400 PLN

Project start date (Y-m-d): 2015-07-21

Project end date (Y-m-d): 2019-07-20

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. adaptera do stereotakcji wraz z maską do anastezji dla myszy.
  2. Homogenizator mechaniczny wraz z akcesoriami (15 000 PLN)
  3. pHmetr (8 000 PLN)

Information in the final report

  • Publication in academic press/journals (10)
  • Articles in post-conference publications (1)
  • Book publications / chapters in book publications (1)
  1. Neuroplasticity and neuroprotective effect of treadmill training in the chronic mouse model of Parkinson's disease
    Authors:
    Ewelina Palasz, Wiktor Niewiadomski, Anna Gasiorowska, Anna Mietelska-Porowska, Grazyna Niewiadomska
    Academic press:
    Neural Plasticity (rok: 2019, tom: 2019:8215017, strony: Article ID 8215017), Wydawca: HINDAWI LTD
    Status:
    Published
    DOI:
    10.1155/2019/8215017 - link to the publication
  2. Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer's Disease and Frontotemporal Lobar Degeneration
    Authors:
    Cranston, Anna L; Wysocka, Adrianna; Steczkowska, Marta; Zadrozny, Marciej; Palasz, Ewelina; Harrington, Charles; Theuring, Franz; Wischik, Ckaude M; Riedel, Gernot; Niewiadomska, Grazyna
    Academic press:
    Brain Communications (rok: 2020, tom: 20202/1:fcaa033, strony: -), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/braincomms/fcaa033 - link to the publication
  3. Pore-former enabled seeding of tau in rats: Alleviation by memantine and lithium chloride.
    Authors:
    Mietelska-Porowska A, Gasiorowska A, Palasz E, Koss DJ, Riedel G, Niewiadomska G.
    Academic press:
    J Neurosci Methods (rok: 2019, tom: 319, strony: 47-59), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.jneumeth.2018.11.009 - link to the publication
  4. Rola czynników troficznych i procesów zapalnych w neuroprotekcji indukowanej wysiłkiem w chorobie Parkinsona
    Authors:
    Pałasz E, Bąk A, Gąsiorowska A, Niewiadomska G.
    Academic press:
    Postepy Hig Med Dosw (Online). 2017 Jan 4;71(1):713-726. (rok: 2017, tom: 71(1), strony: 713-726), Wydawca: POLISH ACAD SCIENCES, INST IMMUNOL & EXP THERAPY, Wrocław
    Status:
    Published
  5. Dangerous Liaisons: Tau Interaction with Muscarinic Receptors
    Authors:
    Adrianna Wysocka, Ewelina Palasz, Marta Steczkowska and Grazyna Niewiadomska
    Academic press:
    Current Alzheimer's Research (rok: 2020, tom: 17, strony: 45304), Wydawca: BENTHAM SCIENCE PUBL LTD
    Status:
    Published
    DOI:
    10.2174/1567205017666200424134311 - link to the publication
  6. Exercise-induced neuroprotection and recovery of motor function in animal models of Parkinson's disease
    Authors:
    Ewelina Palasz, Wiktor Niewiadomski, Anna Gasiorowska, Adrianna Wysocka, Anna Stepniewska and Grazyna Niewiadomska*
    Academic press:
    Frontiers in Neurology (rok: 2019, tom: 2019;10:1143, strony: -), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fneur.2019.01143 - link to the publication
  7. HSP90 and Its Novel Co-Chaperones, SGT1 and CHP-1, in Brain of Patients with Parkinson's Disease and Dementia with Lewy Bodies.
    Authors:
    Bohush A, Niewiadomska G, Weis S, Filipek A.
    Academic press:
    J Parkinsons Dis. (rok: 2019, tom: 9, strony: 97-107), Wydawca: IOS PRESS
    Status:
    Published
    DOI:
    10.3233/JPD-181443. - link to the publication
  8. Role of Mitogen Activated Protein Kinase Signaling in Parkinson's Disease
    Authors:
    Anastasiia Bohush, Grazyna Niewiadomska and Anna Filipek
    Academic press:
    Int. J. Mol. Sci. (rok: 2018, tom: 19, strony: E2973), Wydawca: MDPI (Basel, Switzerland)
    Status:
    Published
    DOI:
    10.3390/ijms19102973 - link to the publication
  9. TracMouse: A computer aided movement analysis script for the mouse inverted horizontal grid test
    Authors:
    W. Niewiadomski1,2, E. Palasz3, M. Skupinska3, M. Zylinski4, M. Steczkowska3, A. Gasiorowska1,3, G. Niewiadomska3 & G. Riedel5
    Academic press:
    Scientific Report (rok: 2016, tom: 6, 39331, strony: 45306), Wydawca: Springer Nature Group
    Status:
    Published
    DOI:
    10.1038/srep39331 - link to the publication
  10. WZMOŻONA AKTYWNOŚĆ FIZYCZNA JAKO TERAPIA WSPOMAGAJĄCA W CHOROBIE PARKINSONA – BADANIA U LUDZI I ZWIERZĄT
    Authors:
    Ewelina Pałasz, Agnieszka Bąk, Grażyna Niewiadomska
    Academic press:
    KOSMOS (rok: 2016, tom: 65, (3), strony: 351-360), Wydawca: Polskie Towarzystwo Przyrodników im. M. Kopernika
    Status:
    Published
  1. Attenuated staining of cholonergic markers in the basal forebrain in murine model of Alzheimer's type tauopathy but not of frontotemporal lobar degeneration tauopathy.
    Authors:
    Adrianna Wysocka, Maciej Zadrożny, Marta Steczkowska, Grażyna Niewiadomska
    Conference:
    XVth International Symposium on Cholinergic Mechanisms, 16-20 October 2016, Marseille, France (rok: 2017, ), Wydawca: J. Neurochemistry 142, S2
    Data:
    konferencja 15-20 października 2016
    Status:
    Published
  1. Interakcja białka tau z receptorem muskarynowym: znaczenie w rozwoju zespołów otępiennych typu tauopatii.
    Authors:
    Maciej Zadrożny, Marta Steczkowska, Adrianna Wysocka
    Book:
    Diagnostyka, profilaktyka, leczenie - najnowsze doniesienia. (rok: 2017, tom: Tom II, strony: 106-125), Wydawca: Wydawnictwo Naukowe TYGIEL
    Status:
    Published