Determination of physicochemical and biochemical propertiess of natural pyridine and piperidine alkaloids and their simple derivatives from the point of view of search for agents against Alzheimer's disese
2012/07/N/NZ7/04275
Keywords
Descriptors
- NZ7_14: Farmacja, farmakoterapia, farmakologia
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej
Voivodeship: pomorskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 3
Call
PRELUDIUM 4 – announced on 2012-09-15
- Amount awarded
- 149 950 PLN
- Project start date
- 2013-09-02
- Project end date
- 2017-09-01
- Project duration
- 48 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- Labirynt promienisty. Cost: 35 000 PLN
- Oprogramowanie do śledzenia ruchów zwierząt w labiryncie. Cost: 9 000 PLN
Information in the final report
Publication in academic press/journals (2)
-
Quantitative determination of trigonelline in mice serum by means of hydrophilic interaction liquid chromatography-MS/MS analysis – application to a pharmacokinetic study
- Authors:
- Damian Szczesny, Ewa Bartosińska, Julia Jacyna, Małgorzata Patejko, Danuta Siluk, Roman Kaliszan
- Academic press:
- Biomedical Chromatography (year: 2017, volume: 32, pages: 46031), Publisher: John Wiley & Sons Ltd
- Status:
- Published
- DOI:
- 10.1002/bmc.4054 – link to the publication
-
Preliminary studies on trigonelline as potential anti-Alzheimer disease agent: determination by hydrophilic interaction liquid chromatography and modeling of interactions with beta-amyloid
- Authors:
- Joanna Makowska, Damian Szczesny, Agnieszka Lichucka, Artutr Giełdoń, Lech Chmurzyński, Roman Kaliszan
- Academic press:
- Journal of Chromatography B (year: 2014, volume: 968, pages: 101-104), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.jchromb.2013.12.001. – link to the publication