Projects funded by the NCN
Determination of physicochemical and biochemical propertiess of natural pyridine and piperidine alkaloids and their simple derivatives from the point of view of search for agents against Alzheimer's disese
2012/07/N/NZ7/04275
Keywords:
Alzheimer's disease neurodegeneration pharmacokinetics pharmacodynamics molecular modeling
Descriptors:
- NZ7_14: Pharmacy, pharmacotherapy, pharmacology
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej
woj. pomorskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 3
Call: PRELUDIUM 4 - announced on 2012-09-15
Amount awarded: 149 950 PLN
Project start date (Y-m-d): 2013-09-02
Project end date (Y-m-d): 2017-09-01
Project duration:: 48 months (the same as in the proposal)
Project status: Project settled
Equipment purchased [PL]
- Labirynt promienisty (35 000 PLN)
- Oprogramowanie do śledzenia ruchów zwierząt w labiryncie (9 000 PLN)
Information in the final report
- Publication in academic press/journals (2)
- Preliminary studies on trigonelline as potential anti-Alzheimer disease agent: determination by hydrophilic interaction liquid chromatography and modeling of interactions with beta-amyloidAuthors:Joanna Makowska, Damian Szczesny, Agnieszka Lichucka, Artutr Giełdoń, Lech Chmurzyński, Roman KaliszanAcademic press:Journal of Chromatography B (rok: 2014, tom: 968, strony: 101-104), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.jchromb.2013.12.001. - link to the publication
- Quantitative determination of trigonelline in mice serum by means of hydrophilic interaction liquid chromatography-MS/MS analysis – application to a pharmacokinetic studyAuthors:Damian Szczesny, Ewa Bartosińska, Julia Jacyna, Małgorzata Patejko, Danuta Siluk, Roman KaliszanAcademic press:Biomedical Chromatography (rok: 2017, tom: 32, strony: 45300), Wydawca: John Wiley & Sons LtdStatus:PublishedDOI:10.1002/bmc.4054 - link to the publication