Projects funded by the NCN

Novel hybrid coatings with advanced antimicrobial properties for surface modification in atmospheric water harvesting sy...

Call: OPUS 27 , Panel: ST11

Principal investigator: prof. Anna Elżbieta Kowalewska

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Analysis of pharmacokinetic, pharmacodynamic and molecular determinants of intolerance and resistance to the Janus kinas...

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr hab. Marta Katarzyna Karaźniewicz-Łada

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

The human ear dynamics stimulated by piezoelectric membrane - novel hybrid model

Call: OPUS 27 , Panel: ST8

Principal investigator: prof. Rafał Sławomir Rusinek

Politechnika Lubelska

Autophagy stimulation by genistein to cure Alzheimer disease: mechanisms and effects investigated using genetic (cellula...

Call: OPUS 27 , Panel: NZ2

Principal investigator: prof. Grzegorz Władysław Węgrzyn

Uniwersytet Gdański

Frog skin derived cyclic peptide as a molecular scaffold to create a novel tool for combining visualization and inhibiti...

Call: PRELUDIUM 23 , Panel: ST5

Principal investigator: Aleksandra Dorota Helbik-Maciejewska

Uniwersytet Gdański

Development of novel screening method for identifying xanthine oxidase inhibitors – towards new drug candidates for gout...

Call: PRELUDIUM 23 , Panel: ST4

Principal investigator: Monika Katarzyna Rola

Politechnika Łódzka

Small molecule modulators of the tumor necrosis factor alpha signaling pathway for the inhibition of inflammatory proces...

Call: OPUS 27 , Panel: NZ7

Principal investigator: prof. Tadeusz Holak

Uniwersytet Gdański

Innovative Small Molecule Inhibitors Targeting LAG-3 and MHCII Complex for Tumour Immunotherapy

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr Jacek Plewka

Uniwersytet Jagielloński

Behavioral timescale plasticity in inhibitory synapses: mechanisms and implications

Call: OPUS 27 , Panel: NZ4

Principal investigator: dr Grzegorz Tadeusz Wiera

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

Controlling the covalent activity of a PD-L1 inhibitors with light

Call: PRELUDIUM 23 , Panel: NZ7

Principal investigator: Wiktor Jan Uzar

Uniwersytet Jagielloński

Metastasis process regulation by inhibiting neutrophils NETosis through phytocannabinoids and the endocannabinoid system

Call: PRELUDIUM 23 , Panel: NZ1

Principal investigator: Izabela Marianna Krauze

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

Changes in physiological properties of the elbow flexors muscles after the second bout of eccentric exercise compared to...

Call: PRELUDIUM 1 , Panel: NZ7

Principal investigator: dr Damian Dariusz Janecki

AKADEMIA WYCHOWANIA FIZYCZNEGO WE WROCŁAWIU

Development and characterization of novel multitargeted organometallic tubulin polymerization inhibitors for enhancing t...

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr hab. Damian Nestor Plażuk

Uniwersytet Łódzki

Persistent phosphors based on luminescent spinel nanocrystals exhibiting quantum-cutting effect for bio-imaging

Call: DAINA 3 , Panel: ST5

Principal investigator: prof. Dariusz Grzegorz Hreniak

Instytut Niskich Temperatur i Badań Strukturalnych im. Włodzimierza Trzebiatowskiego Polskiej Akademii Nauk

Early Intervention with mTOR Inhibitors for Neuropsychiatric Symptoms in Tuberous Sclerosis Complex: Unveiling Developme...

Call: DAINA 3 , Panel: NZ4

Principal investigator: prof. Ewelina Anna Knapska

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

Interaction between temporal predictability and action control in ADHD and Parkinson's Disease: behavioural, neurophysio...

Call: SONATINA 8 , Panel: HS6

Principal investigator: dr Inga Justyna Korolczuk

Uniwersytet Medyczny w Lublinie

Selective inhibition of Janus kinases for the treatment of autoimmune hepatitis: Translational PK/PD modelling from mole...

Call: SONATA 19 , Panel: NZ7

Principal investigator: dr Artur Świerczek

Uniwersytet Jagielloński, Collegium Medicum

Inhibitory Functional Networks in Addiction Development within Social Context - a Missing Piece of Puzzle

Call: OPUS 26 , Panel: NZ4

Principal investigator: dr Marzena Stefaniuk

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

Design, synthesis and biological evaluation of Steroid Sulfatase Inhibitors based on organophosphorus compounds.

Call: SONATA 2 , Panel: NZ7

Principal investigator: dr Sebastian Demkowicz

Politechnika Gdańska

Flozins as potential inhibitors of aortic stenosis progression in patients with concomitant type 2 diabetes: impact on v...

Call: OPUS 26 , Panel: NZ5

Principal investigator: dr hab. Joanna Natorska

Uniwersytet Jagielloński

Optogenetic and chemogenetic identification of brain circuits and cellular mechanisms underlying antidepressants resista...

Call: OPUS 26 , Panel: NZ7

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Restoring Beta-cell Integrity through Targeted SPOP Inhibition and PDX-1 Preservation

Call: OPUS 26 (LAP) , Panel: NZ7

Principal investigator: dr Anna Czarna

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Modulation of the N-glycosylation as a tool to improve the CAR-T immunotherapy efficacy

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr Agnieszka Graczyk-Jarzynka

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

Analysis of a mechanism, mediators and sequence of events in the context of an assessment of stimulatory effect of senes...

Call: OPUS 2 , Panel: NZ3

Principal investigator: dr hab. Krzysztof Stefan Książek

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski II

Targeting adenylate kinase 4 (AK4) as a new paradigm in the treatment of non-small cell lung cancer: discovery and evalu...

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr Magdalena Wujak

Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

More knowledge per hectare? Economic and environmental aspects of technological change stimulated by investments in prec...

Call: SONATA 19 , Panel: HS4

Principal investigator: dr Jakub Józef Staniszewski

Uniwersytet Ekonomiczny w Poznaniu

Novel aspects of the mechanisms of vascular toxicity of tyrosine kinase inhibitors: studies on their proinflammatory act...

Call: OPUS 26 , Panel: NZ5

Principal investigator: dr Tomasz Krzysztof Prajsnar

Uniwersytet Jagielloński, Wydział Biologii

Can extracts from Epilobium sp. inhibit proliferation of prostate cell LNCaP by influencing the activity of histone acet...

Call: SONATA 1 , Panel: NZ4

Principal investigator: dr hab. Anna Karolina Kiss

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny

Functional and structural analysis of anticancer drugs as protein biosynthesis inhibitors

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr hab. Witold Szaflarski

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

Design and synthesis of new rifampicin analogs as a source of effective bacterial RNA polymerase inhibitors

Call: OPUS 2 , Panel: ST5

Principal investigator: dr hab. Piotr Przybylski

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

Raman4Cell2Cell: Uncovering the reciprocal interactions of leukocytes and endothelial cells by (stimulated) Raman imagin...

Call: OPUS 26 , Panel: ST4

Principal investigator: dr Aleksandra Maria Borek-Dorosz

Uniwersytet Jagielloński, Wydział Chemii

Design and Development of Serine Hydroxymethyltransferase-2 (SHMT2) Inhibitors Blocking Tumor Growth

Call: SONATA BIS 13 , Panel: NZ7

Principal investigator: dr hab. Miłosz Ruszkowski

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

The inhibition of NMDAR and TRPM4 coupling - a hope for novel therapeutic target for the treatment of the ischemic brain...

Call: SONATA BIS 13 , Panel: NZ7

Principal investigator: dr Bartosz Sebastian Pomierny

Uniwersytet Jagielloński, Collegium Medicum

Physiological significance and clinical implications of global and local inhibition of NRF2 transcriptional activity in ...

Call: SONATA BIS 13 , Panel: NZ4

Principal investigator: dr hab. Aleksandra Barbara Piechota-Polańczyk

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Molecular mechanisms of DNA damage triggered by PIM kinases inhibition and its consequences for activation of innate imm...

Call: OPUS 25 , Panel: NZ5

Principal investigator: prof. Przemysław Juszczyński

Instytut Hematologii i Transfuzjologii

Theoretical prediction, chemical synthesis and biological analysis of a novel class of HSPA5 inhibitors

Call: OPUS 25 , Panel: ST4

Principal investigator: prof. Arkadiusz Chworoś

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Compounds modulating function of telomeric proteins TRF1 and TRF2

Call: OPUS 25 , Panel: NZ7

Principal investigator: prof. Maciej Wojciech Bagiński

Politechnika Gdańska, Wydział Chemiczny

Unraveling protease activation in stimulated CAR-T cells to identify new biomarkers for assessing their clinical efficac...

Call: OPUS 25 , Panel: NZ7

Principal investigator: dr hab. Małgorzata Firczuk

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

Synthesis and biological activity evaluation of new hybrid derivatives of tacrine and melatonin as potential cholinester...

Call: OPUS 2 , Panel: ST5

Principal investigator: dr Anna Zawadzka

Uniwersytet Warszawski, Wydział Chemii

Development of dual immuno-oligo- biosensors for monitoring and controlling of the metastatic colorectal cancer and inve...

Call: OPUS 25 , Panel: ST4

Principal investigator: dr hab. Magdalena Stobiecka

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Biologii

Investigating the mechanisms of CD20 downregulation triggered by tyrosine kinase inhibitors in Philadelphia chromosome-p...

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: Krzysztof Domka

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

Understanding the contribution of immunoproteasome activation to the neuropathic pain development.

Call: OPUS 25 , Panel: NZ7

Principal investigator: dr Natalia Eleonora Małek-Chudzik

Politechnika Wrocławska

Search for novel IKK-β inhibitors in the context of diseases with neuroinflammatory origin – structure-based drug design...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Emilia Aleksandra Sługocka

Uniwersytet Jagielloński, Collegium Medicum

Targeting Energy Metabolism for Precision Cancer Therapy: Novel Inhibitors of LDH-A and PDK1 as Potential Strategies to ...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Marika Anna Frańczak

Gdański Uniwersytet Medyczny, Wydział Lekarski

The design and development of the peptide inhibitors library targeting Zn(II)-binding site of matrix metalloproteinases ...

Call: PRELUDIUM 22 , Panel: ST5

Principal investigator: Paulina Alicja Potok

Uniwersytet Wrocławski, Wydział Chemii

Endothelial bioenergetics as a novel target for vascular protection – unveiling the mitochondrial mechanisms of lipid-lo...

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: dr Alicja Małgorzata Braczko

Gdański Uniwersytet Medyczny, Wydział Lekarski

Computational alchemy and experimental validation: a hybrid approach for designing new antimicrobial peptides

Call: PRELUDIUM 22 , Panel: NZ1

Principal investigator: Piotr Maciej Chyży

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

The effect of Tcf7l2 knockout on excitation/inhibition balance in neuronal circuits of the thalamus

Call: PRELUDIUM 22 , Panel: NZ3

Principal investigator: Katarzyna Aleksandra Hryniewiecka

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Multiparameter analysis of co-inhibitory and co-stimulatory immune checkpoints and their role in the induction of immuno...

Call: PRELUDIUM 22 , Panel: NZ6

Principal investigator: Dorota Suszczyk

Uniwersytet Medyczny w Lublinie

Designing Active Inhibitors of SARS-CoV-2 Methyltransferases

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Alex Jun Matsuda

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego