Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Study of casein kinase CK2 inhibition mechanisms

2011/01/B/ST5/00849

Keywords:

Kinase CK2 inhibitors anticancer agents human CK2 overexpression

Descriptors:

  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Politechnika Warszawska, Wydział Chemiczny, Wydział Chemiczny

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maria Bretner 

Number of co-investigators in the project: 8

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 603 400 PLN

Project start date (Y-m-d): 2011-12-01

Project end date (Y-m-d): 2015-11-30

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. inkubator z wytrząsaniem (35 000 PLN)
  2. aparat do elektroforezy z wyposażeniem (12 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  1. Synthesis of novel chiral TBBt derivatives with hydroxyl moiety. Studies on inhibition of human protein kinase CK2 a and cytotoxicity properties."
    Authors:
    Borowiecki P., Wawro A.M., Wińska P., Wielechowska M., Bretner M
    Academic press:
    Eur. J Med. Chem (rok: 2014, tom: 84, strony: 364-374), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2014.07.019 - link to the publication
  2. Synthesis of 4,5,6,7-Tetrabromo-1H-benzimidazole Derivatives
    Authors:
    Łukowska-Chojnacka E., Bretner M
    Academic press:
    JOURNAL OF HETEROCYCLIC CHEMISTRY (rok: 2015, tom: 52, strony: 841-845), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/jhet.2145 - link to the publication
  3. Synthesis of new optically pure tetrabromobenzotriazole derivatives via lipase-catalyzed transesterification
    Authors:
    Adam M. Wawro, Monika Wielechowska, Maria Bretner,
    Academic press:
    Journal of Molecular Catalysis B: Enzymatic (rok: 2013, tom: 87, strony: 44-50), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.013 - link to the publication
  4. Synthesis of polybrominated benzimidazole and benzotriazole derivatives containing tetrazole ring and their antitumor activity
    Authors:
    Edyta Łukowska-Chojnacka, Patrycja Wińska, Monika Wielechowska, Maria Bretner
    Academic press:
    Monatshefte für Chemie - Chemical Monthly (rok: 2016, tom: open access, strony: 8), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00706-016-1785-8 - link to the publication
  5. Thermodynamic parameters for binding of some halogenated inhibitors of human protein kinase CK2
    Authors:
    Winiewska M., Makowska M., Maj P., Wielechowska M., Bretner M., Poznański J., Shugar D.
    Academic press:
    Biochemical and Biophysical Research Communications (rok: 2015, tom: 456, strony: 282-287), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbrc.2014.11.072 - link to the publication
  6. Synthesis of novel polybrominated benzimidazole derivatives—potential CK2 inhibitors with anticancer and proapoptotic activity
    Authors:
    Łukowska-Chojnacka E., Wińska P., Wielechowska M., Poprzeczko M., Bretner M.
    Academic press:
    Bioorganic & Medicinal Chemistry (rok: 2016, ), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.bmc.2015.12.041 - link to the publication

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