Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Stimulation of endogenous neurogenesis as a novel therapeutic strategy in neonatal hypoxic-ischemic brain injury.

2012/05/B/NZ3/00436

Keywords:

stimulation of neurogenesis hypoxia-ischemia HDAC inhibitors GSK-3 inhibitor

Descriptors:

  • NZ3_6: Cell neurobiology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Małgorzata Nałęcz 

Number of co-investigators in the project: 3

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 329 370 PLN

Project start date (Y-m-d): 2013-02-21

Project end date (Y-m-d): 2016-10-20

Project duration:: 44 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Lupa stomatologiczna Zeiss (7 500 PLN)
  2. Pompa perystaltyczna (6 000 PLN)
  3. Aparat anestezjologiczny z parownikiem na izofluran (17 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Sodium butyrate, a histone deacetylase inhibitor, exhibits neuroprotective/neurogenic effects in a rat model of neonatal hypoxia-ischemia
    Authors:
    Ziemka-Nalecz M, Jaworska J, Sypecka J, Polowy R, Filipkowski RK, Zalewska T
    Academic press:
    Molecular Neurobiology (rok: 2017, tom: 54, strony: 5300–5318), Wydawca: Springer Link
    Status:
    Published
    DOI:
    10.1007/s12035-016-0049-2 - link to the publication
  2. Neuroprotective effects of histone deacetylase inhibitors in brain ischemia
    Authors:
    Małgorzata Ziemka-Nałęcz, Teresa Zalewska
    Academic press:
    Acta Neurobiologiae Experimentalis (rok: 2014, tom: 74, strony: 383-395), Wydawca: The Nencki Institute and Polish Neuroscience Society
    Status:
    Published
    DOI:
    brak - link to the publication
  3. The potential neuroprotective role of a histone deacetylase inhibitor, Sodium Butyrate, after neonatal hypoxia-ischemia.
    Authors:
    Joanna Jaworska, Malgorzata Ziemka-Nalecz, Joanna Sypecka, Teresa Zalewska
    Academic press:
    Journal of Neuroinflammation (rok: 2017, tom: 14, strony: 34-51), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12974-017-0807-8 - link to the publication
  4. A simple, xeno-free method for oligodendrocyte generation from human neural stem cells derived from umbilical cord: engagement of gelatinases in cell commitment and differentiation.
    Authors:
    Joanna Sypecka, Małgorzata Ziemka-Nałęcz, Patrycja Dragun-Szymczak, Teresa Zalewska
    Academic press:
    Journal of Tissue Engineering and Regenerative Medicine (rok: 2017, tom: 11, strony: 1442 – 1455), Wydawca: John Wiley & Sons Inc
    Status:
    Published
    DOI:
    10.1002/term.2042 - link to the publication
  5. Histone deacetylases 1 and 2 are required for brain development
    Authors:
    Joanna Jaworska, Malgorzata Ziemka-Nalecz, Teresa Zalewska
    Academic press:
    The International Journal of Developmental Biology (rok: 2015, tom: 59, strony: 171-177), Wydawca: University of the Basque Country Press
    Status:
    Published
    DOI:
    10.1387/ijdb.150071tz - link to the publication
  6. Current and experimental pharmacological approaches in neonatal hypoxic- ischemic encephalopathy
    Authors:
    Teresa Zalewska, Joanna Jaworska, Małgorzata Ziemka-Nałęcz
    Academic press:
    Current Pharmaceutical Design (rok: 2015, tom: 21, strony: 1433-1439), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1381612820999141029162457 - link to the publication
  7. Oxygen-glucose deprivation promotes gliogenesis and microglia activation in organotypic hippocampal slice culture: involvement of metalloproteinases.
    Authors:
    Małgorzata Ziemka-Nałęcz, Luiza Stanaszek, Teresa Zalewska
    Academic press:
    Acta Neurobiologiae Experimentalis (rok: 2013, tom: 73(1), strony: 130-142), Wydawca: The Nencki Institute and Polish Neuroscience Society
    Status:
    Published
    DOI:
    brak - link to the publication

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