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Information on the principal investigator and host institution

Information of the project and the call

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The effect of the novel atypical neuroleptics on the activity and expression of cytochrome P450 isoforms in human liver

2013/11/B/NZ7/01627

Keywords:

human cytochrome P450 inhibition induction novel atypical neuroleptics

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Jacek Wójcikowski 

Number of co-investigators in the project: 3

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 497 890 PLN

Project start date (Y-m-d): 2014-07-22

Project end date (Y-m-d): 2017-12-21

Project duration:: 41 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zestaw do odparowywania próbek w strumieniu azotu (75 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (5)
  1. Asenapine and iloperidone decrease the expression of major cytochrome P450 enzymes CYP1A2 and CYP3A4 in human hepatocytes. A significance for drug-drug interactions during combined therapy.
    Authors:
    Danek PJ, Wójcikowski J, Daniel WA
    Academic press:
    Toxicology and Applied Pharmacology (rok: 2020, tom: 406, strony: 115239), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.taap.2020.115239 - link to the publication
  2. In vitro inhibition of human cytochrome P450 enzymes by the novel atypical antipsychotic drug asenapine: a prediction of possible drug-drug interactions.
    Authors:
    Wójcikowski J, Danek PJ, Basińska-Ziobroń A, Pukło R, Daniel WA.
    Academic press:
    Pharmacological Reports (rok: 2020, tom: 72, strony: 612-621), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-020-00089-z - link to the publication
  3. The atypical neuroleptics iloperidone and lurasidone inhibit human cytochrome P450 enzymes in vitro. Evaluation of potential metabolic interactions.
    Authors:
    Danek PJ, Wójcikowski J, Daniel WA
    Academic press:
    Pharmacological Reports (rok: 2020, tom: 72, strony: b.d.), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-020-00102-5 - link to the publication
  1. In vitro inhibition of human cytochrome P450 isoenzymes by the novel atypical antipsychotic drug iloperidone
    Authors:
    Wójcikowski J., Danek P., Daniel W.A.
    Conference:
    13th World Congress of Biological Psychiatry (rok: 2017, ), Wydawca: WFSBP Congress, Copenhagen, 2017
    Data:
    konferencja 18-22 czerwca
    Status:
    Published
    DOI:
    link to the publication
  2. The effect of the novel atypical antipsychotic drug lurasidone on cytochrome P450 isoenzyme activities in human liver
    Authors:
    Wójcikowski J., Basińska-Ziobroń A., Danek P., Daniel W.A.
    Conference:
    2nd Central European Biomedical Congress - From emerging biochemical strategies to personalized medicine (rok: 2016, ), Wydawca: CEBC, Cracow, 2016
    Data:
    konferencja 15-18 czerwca
    Status:
    Published
  3. Inhibition of human cytochrome P450 isoenzymes by the novel atypical antipsychotic drug asenapine
    Authors:
    Wójcikowski J., Asztabski M., Basińska A., Daniel W.A.
    Conference:
    19th International Conference on Cytochrome P450. Biochemistry, Biophysics and Biotechnology. (rok: 2015, ), Wydawca: ICCP450, Tokyo, 2015
    Data:
    konferencja 12-15 czerwca
    Status:
    Published
  4. Potent inhibition of CYP1A2 and CYP2D6 by the novel antipsychotic drug asenapine in human liver
    Authors:
    Wójcikowski J., Basińska-Ziobroń A., Daniel W.A.
    Conference:
    29th ECNP Congress (rok: 2016, ), Wydawca: Elsevier
    Data:
    konferencja 17-20 września
    Status:
    Published
  5. Potent inhibition of human CYP3A4 by the novel atypical antipsychotic drug iloperidone
    Authors:
    Wójcikowski J., Danek P., Daniel W.A.
    Conference:
    6th Mediterranean Neuroscience Society Conference (rok: 2017, ), Wydawca: Malta Chamber of Scientists
    Data:
    konferencja 12-15 czerwca
    Status:
    Published

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