Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Inter- and intracellular signalling in innate immune response: experimental and mathematical analysis

2011/03/B/NZ2/00281

Keywords:

signalling pathways IRF3 NF-kB LPS stimulation single-cell imaging fluorescent probe-tagged proteins microfluidic chips

Descriptors:

  • NZ2_9: Systems biology
  • NZ2_10: Biological systems analysis, modelling and simulation
  • NZ3_7: Signal transduction

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Instytut Podstawowych Problemów Techniki PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Tomasz Lipniacki 

Number of co-investigators in the project: 6

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 562 761 PLN

Project start date (Y-m-d): 2012-08-06

Project end date (Y-m-d): 2016-02-05

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. karta wielofunkcyjna DAQ (12 000 PLN)
  2. pakiet oprogramowania "LabView" (10 000 PLN)
  3. trzy komputery klasy PC do obsługi aparatury pomiarowej, analizy danych pomiarowych oraz symulacji numerycznych (12 565 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  1. Dynamic cross talk model of the epithelial innate immune response to double-stranded RNA stimulation: coordinated dynamics emerging from cell-level noise
    Authors:
    Bertolusso R, Tian B, Zhao Y, Vergara L, Sabree A, Iwanaszko M, Lipniacki T, Brasier AR, Kimmel M
    Academic press:
    PLOS One (rok: 2014, tom: 9, strony: e93396), Wydawca: PUBLIC LIBRARY SCIENCE
    Status:
    Published
    DOI:
    10.1371/journal.pone.0093396 - link to the publication
  2. Clustering reveals limits of parameter identifiability in multi-parameter models of biochemical dynamic
    Authors:
    Nienałtowski K., Włodarczyk M., Lipniacki T., Komorowski M.
    Academic press:
    BMC SYSTEMS BIOLOGY (rok: 2015, tom: 0,420138888888889, strony: 45300), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12918-015-0205-8 - link to the publication
  3. Stability of bacterial toggle switches is enhanced by cell-cycle lengthening by several orders of magnitude
    Authors:
    Jaruszewicz J, Kimmel M, Lipniacki T
    Academic press:
    Physical Review E (rok: 2014, tom: 89, strony: 22710), Wydawca: AMER PHYSICAL SOC
    Status:
    Published
    DOI:
    10.1103/PhysRevE.89.022710 - link to the publication
  4. Computational Analysis of an Autophagy/Translation Switch Based on Mutual Inhibition of M TORC1 and ULK1
    Authors:
    Szymańska P, Martin KR, MacKeigan JP , Hlavacek WS, Lipniacki T
    Academic press:
    PLOS One (rok: 2015, tom: 10, strony: e0116550), Wydawca: PUBLIC LIBRARY SCIENCE
    Status:
    Published
    DOI:
    10.1371/journal.pone.0116550 - link to the publication
  5. Digital signaling decouples activation probability and population heterogeneity
    Authors:
    RA Kellogg, C Tian, T Lipniacki, SR Quake, S Tay
    Academic press:
    eLife (rok: 2015, tom: 4, strony: e08931), Wydawca: eLife Sciences Publications LTD
    Status:
    Published
    DOI:
    10.7554/eLife.08931 - link to the publication
  6. Levels of pro-apoptotic regulator Bad and anti-apoptotic regulator Bcl-xL determine the type of the apoptotic logic gate
    Authors:
    Bogdał MN, Hat B, Kochańczyk M, Lipniacki T
    Academic press:
    BMC Systems Biology (rok: 2013, tom: 7, strony: 67), Wydawca: BIOMED CENTRAL LTD
    Status:
    Published
    DOI:
    10.1186/1752-0509-7-67 - link to the publication
  7. Cell fate in antiviral response is decided in the crosstalk of the IRF, NF-κB and JAK/STAT pathways
    Authors:
    Czerkies M, Korwek Z, Prus W, Kochańczyk M, Jaruszewicz-Błońska J, Tudelska K, Błoński S, Kimmel M, Brasier AR, Lipniacki T
    Academic press:
    Nature Communications , Wydawca: Nature Publishing Group
    Status:
    Submitted
    DOI:
    brak - link to the publication
  8. Effective reaction rates in diffusion-limited phosphorylation-dephosphorylation cycles
    Authors:
    Szymańska P, Kochańczyk M, Miękisz J, Lipniacki T
    Academic press:
    Physical Review E (rok: 2015, tom: 91, strony: 22702), Wydawca: AMER PHYSICAL SOC
    Status:
    Published
    DOI:
    10.1103/PhysRevE.91.022702 - link to the publication
  9. Spontaneous NF-κB Activation by Autocrine TNFα Signaling: A Computational Analysis
    Authors:
    Pękalski J, Zuk PJ, Kochańczyk M, Junkin M, Kellog R, Tay S, Lipniacki T
    Academic press:
    PLOS One (rok: 2013, tom: 8, strony: e78887), Wydawca: PUBLIC LIBRARY SCIENCE
    Status:
    Published
    DOI:
    10.1371/journal.pone.0078887 - link to the publication

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