Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Theoretical model of SH2-dependent STAT1 dimerization as a novel tool to identify specific compounds of functional inhibition

2012/07/N/NZ2/01359

Keywords:

STAT1 protein SH2 domain specific inhibitor atherosclerosis

Descriptors:

  • NZ2_7: Bioinformatics
  • NZ1_9: Biotechnology
  • ST4_15: Colloid chemistry

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Małgorzata Szeląg 

Number of co-investigators in the project: 3

Call: PRELUDIUM 4 - announced on 2012-09-15

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2013-07-17

Project end date (Y-m-d): 2016-07-16

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komputer wieloprocesorowy z monitorem 27-calowym (6 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Identyfication of STAT1 and STAT3 specific inhibitors using comparative virtual screening and docking validation
    Authors:
    Szeląg M., Czerwoniec A., Wesoły J., Bluyssen H.A.R.
    Academic press:
    PLoS One (rok: 2015, tom: 10(2), strony: e0116688), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0116688 - link to the publication
  2. In silico simulations of STAT1 and STAT3 inhibitors predict SH2 domain cross-binding specificity
    Authors:
    Szeląg M., Sikorski K., Czerwoniec A., Szatkowska K., Wesoły J., Bluyssen H.A.R.
    Academic press:
    European Journal of Pharmacology (rok: 2013, tom: 720, strony: 38-48), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.055 - link to the publication
  3. CAVS – Novel in silico selection strategy of specific STAT inhibitory compounds
    Authors:
    Czerwoniec A., Szelag M., Juszczak K., Wesoly J., Bluyssen H.A.R.
    Academic press:
    Journal of Computational Science (rok: 2015, tom: -, strony: -), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jocs.2015.03.001 - link to the publication
  4. Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease
    Authors:
    Szelag M, Piaszyk-Borychowska A, Plens-Galaska M, Wesoly J, Bluyssen HAR
    Academic press:
    Oncotarget (rok: 2016, tom: 7(30), strony: 48788-48812), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.9195 - link to the publication
  5. A theoretical antioxidant pharmacophore for natural hydroxycinnamic acids
    Authors:
    Szelag M., Urbaniak A., Bluyssen H.A.R.
    Academic press:
    Open Chemistry (rok: 2015, tom: 13, strony: 17-31), Wydawca: De Gruyter
    Status:
    Published
    DOI:
    10.1515/chem-2015-0001 - link to the publication
  6. Advances in peptidic and peptidomimetic-based approaches to inhibit STAT signaling in human diseases
    Authors:
    Szelag M., Wesoly J., Bluyssen H.A.R.
    Academic press:
    Current Protein and Peptide Science (rok: 2016, tom: 17, strony: 135-146), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1389203716666151102103706 - link to the publication
  7. Comparative screening and validation as a novel tool to identify STAT-specific inhibitors
    Authors:
    Szeląg M., Czerwoniec A., Wesoły J., Bluyssen H.A.R.
    Academic press:
    European Journal of Pharmacology (rok: 2014, tom: 740, strony: 417-420), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2014.05.047 - link to the publication

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