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The reorganization of the spinal neuronal network caused by electrical stimulation of the peripheral nerve in spinal rats

2013/09/B/NZ4/03306

Keywords

Descriptors

  • NZ4_7: Neurofizjologia
  • NZ4_9: Neurobiologia systemowa
  • NZ4_10: Neuroobrazowanie

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Małgorzata Skup

Number of co-investigators in the project: 6

Call

OPUS 5 – announced on 2013-03-15

Amount awarded
985 500 PLN
Project start date
2014-03-12
Project end date
2018-03-11
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Aparat do ilościowego pomiaru ekspresji mRNA w czasie rzeczywistym Real Time PCR System - ekonomiczna wersja aparatu Roche LightCycler® 480, z komputerem i systemem operacyjnym. Cost: 120 000 PLN
  2. Mikrowirówka z chłodzeniem Laboratory Eppendorf 5430R i rotorami wymiennymi na probówki o obj. 1, 5, 15 i 50 ml. Cost: 30 000 PLN
  3. Spektrofotometr BioPhotometer plus firmy Eppendorf. Cost: 20 000 PLN
  4. Stymulator Model 2100 Isolated Pulse Stimulator o parametrach: 220V, 50Hz A-M System. Cost: 9 600 PLN
  5. Wzmacniacz różnicowy Differential AC Amplifier, 220 V, 50 Hz, Model 1700. Cost: 8 400 PLN
  6. komputer do pracy z oprogramowaniem do obróbki i analizy obrazu.
  7. oprogramowanie do analizy obróbki i analizy obrazu i analizy danych elektrofizjologicznych.

Information in the final report

Publication in academic press/journals (4)

  1. Early pre- and postsynaptic decrease in glutamatergic and cholinergic signaling after spinalization is not modified when stimulating proprioceptive input to the ankle extensor alpha-motoneurons: anatomical and neurochemical study

    Authors:
    Kamil Grycz, Anna Glowacka, Benjun Ji, Julita Czarkowska-Bauch, Olga Gajewska-Wozniak, Malgorzata Skup
    Academic press:
    PLOS ONE (year: 2019, volume: 14(9), pages: 46043), Publisher: San Francisco, California and Cambridge, UnitedKingdom.
    Status:
    Published
    DOI:
    10.1371/journal.pone.0222849 – link to the publication

  2. Electrical stimulation of low-threshold proprioceptive fibers in the adult rat increases density of glutamatergic and cholinergic boutons on the ankle extensor α-motoneurons

    Authors:
    Olga Gajewska-Woźniak, Kamil Grycz, Julita Czarkowska-Bauch and Małgorzata Skup
    Academic press:
    PLOS ONE (year: 2016, volume: 11, pages: 46043), Publisher: San Francisco, California, and Cambridge, United Kingdom.
    Status:
    Published
    DOI:
    10.1371/journal.pone.0161614 – link to the publication

  3. Spinalization and locomotor training differentially affect muscarinic acetylcholine receptor type 2 abutting on α-motoneurons innervating the ankle extensor and flexor muscles

    Authors:
    Więckowska Angelika, Gajewska-Woźniak Olga, Głowacka Anna, Ji Benjun, Grycz Kamil, Czarkowska-Bauch Julita and Skup Malgorzata
    Academic press:
    Journal of Neurochemistry (year: 2018, volume: 147, pages: 361-379), Publisher: WILEY-BLACKWELL
    Status:
    Published
    DOI:
    10.1111/jnc.14567 – link to the publication

  4. The impact of training and neurotrophins on functional recovery after complete spinal cord transection: cellular and molecular mechanisms contributing to motor improvement.

    Authors:
    Małgorzata Skup, Ewelina Ziemlińska, Olga Gajewska-Woźniak, Rafał Płatek, Anna Maciejewska, and Julita Czarkowska-Bauch
    Academic press:
    Acta Neurobiologiae Experimentalis (year: 2014, volume: 74, pages: 121-141), Publisher: Nencki Institute of Experimental Biology, Polish Neuroscience Society
    Status:
    Published

Articles in post-conference publications (15)

  1. Differential changes of expression level of Crtl1/Hapln1 link protein in ankle extensor and flexor α-motoneurons in rats after complete spinal cord transection

    Authors:
    Grycz K., Gajewska-Woźniak O., Ji B., Czarkowska-Bauch J., Skup M.
    Conference:
    FENS Forum of Neuroscience (year: 2018, pages: -), Publisher: Federation of European Neuroscience Societies
    Date:
    conference 7-11 lipca
    Status:
    Published

  2. Low-treshold stimulation of the tibial nerve enriches cholinergic innervation of the ankle extensors motoneurons

    Authors:
    Olga Gajewska-Woźniak, Julita Czarkowska-Bauch, Małgorzata Skup
    Conference:
    9th FENS Forum of Neuroscience (year: 2014, pages: FENS 1511 - http://fens2014.meetingxpert.net), Publisher: FENS
    Date:
    conference July 5th - 9th
    Status:
    Published
    DOI:
    link to the publication

  3. Electrical stimulation can increase the density of glutamatergic and cholinergic terminals on motoneurons

    Authors:
    M.SKUP, O.GAJEWSKA-WOŻNIAK, K.GRYCZ, A.GŁOWACKA, B.JI, A.WIĘCKOWSKA, J.CZARKOWSKA-BAUCH
    Conference:
    International Motoneuron Society Conference (year: 2018, pages: -), Publisher: International Motoneuron Society
    Date:
    conference 11-14 czerwca
    Status:
    Published

  4. Enrichment in glutamatergic and cholinergic boutons of ankle extensor α-motoneurons after low-threshold stimulation of proprioceptive fibers in the adult rat

    Authors:
    Olga Gajewska-Woźniak, Małgorzata Skup, Julita Czarkowska-Bauch
    Conference:
    12 International Congress of the Polish Neuroscience Society (year: 2015, pages: S75), Publisher: Acta Neurobiologiae Experimentalis 75 (3)
    Date:
    conference 6-8 September
    Status:
    Published

  5. The effect of low-threshold stimulation of proprioceptive fibers on glutamatergic and cholinergic innervation of the ankle extensor motoneurons after complete transection of the spinal cord.

    Authors:
    Kamil Grycz ,Anna Głowacka A., Olga Gajewska-Woźniak, Benjun Ji, Julita Czarkowka-Bauch, Małgorzata Skup.
    Conference:
    FENS FORUM (year: 2016, pages: 1), Publisher: Federation of European Neuroscience Societies
    Date:
    conference 2-6 lipca
    Status:
    Published

  6. Low-threshold stimulation of proprioceptive fibers in the adult rat is a feasible tool to increase density of glutamatergic and cholinergic boutons on the ankle extensor motoneurons.

    Authors:
    Małgorzata Skup, Olga Gajewska-Woźniak., Kamil Grycz, Julita Czarkowska-Bauch
    Conference:
    FENS FORUM (year: 2016, pages: 1), Publisher: Federation of European Neuroscience Societies
    Date:
    conference 2-6 lipca
    Status:
    Published

  7. The effect of one week of low-treshold stimulation of prioprioceptive fibers on glutamatergic and cholinergic innervation of the ankle extensor a-motoneurons on early phase after complete transection of the spinal cord

    Authors:
    Kamil Grycz, Anna Głowacka, Olga Gajewska-Woźniak, Julita Czarkowska-Bauch, Małgorzata Skup.
    Conference:
    XIII Międzynarodowe Sympozjum Neurochemiczne Molecular basis of pathology and therapy in neurological disorders. (year: 2016, pages: 315), Publisher: Instytut im. M. Mossakowskiego PAN Warszawa; https://www.termedia.pl/Journal/Folia_Neuropathologica-20/Numer-3-2016
    Date:
    conference 17-18 listopada
    Status:
    Published

  8. Spinal BDNF overexpression leads to opposite effects on glutamatergic AMPAR and NMDAR than on muscarinic acetylcholine receptor M2 transcript level in rats with complete spinal cord transection

    Authors:
    Benjun Ji, Anna Głowacka, Olga Gajewska‑Woźniak, Julita Czarkowska‑Bauch, Małgorzata Skup
    Conference:
    13 International Congress of the Polish Neuroscience Society (year: 2017, pages: XCVI), Publisher: Acta Neurobiologiae Experimentalis Vol. 77 No. S1
    Date:
    conference 28-31 August
    Status:
    Published
    DOI:
    link to the publication

  9. Spinal BDNF overexpression partially protects synaptic machinery of neuromuscular junction from disintegration after complete spinal cord transection in adult rats: neurochemical and morphological changes evaluated by histochemical techniques

    Authors:
    Głowacka A, Gajewska-Woźniak O, Bernadzki KM, Czarkowska-Bauch J, Skup M
    Conference:
    13 International Congress of the Polish Neuroscience Society (year: 2017, pages: LXXVI), Publisher: Acta Neurobiologiae Experimentalis Vol. 77 No. S1
    Date:
    conference 28-31 August
    Status:
    Published
    DOI:
    link to the publication

  10. Early changes in gene expression of spinal perineuronal nets components in rats after complete spinal cord transection

    Authors:
    Kamil Grycz, Olga Gajewska‑Woźniak, Benjun Ji, Julita Czarkowska‑Bauch, Małgorzata Skup
    Conference:
    13 International Congress of the Polish Neuroscience Society (year: 2017, pages: XCVIII), Publisher: Acta Neurobiologiae Experimentalis Vol. 77 No. S1
    Date:
    conference 28-31 August
    Status:
    Published
    DOI:
    link to the publication

  11. Stimulation of low-threshold proprioceptive fibers increases density of glutamatergic and cholinergic boutons on the ankle extensor alpha-motoneurons in the adult rat.

    Authors:
    Olga Gajewska-Woźniak, Julita Czarkowska-Bauch, Kamil Grycz, Małgorzata Skup
    Conference:
    Annual Meeting of the Society for Neuroscience (year: 2016, pages: 1), Publisher: American Society for Neuroscience (SfN)
    Date:
    conference 12-16 listopada
    Status:
    Published

  12. Locomotor training of the spinal rats decreases abundance of GlyR anchoring gephyrin in the ankle extensor and flexor motoneurons mildly reducing perineuronal nets encapsulating them

    Authors:
    Małgorzata Skup, Anna Głowacka, Olga Gajewska-Woźniak, Julita Czarkowska-Bauch
    Conference:
    12 International Congress of the Polish Neuroscience Society (year: 2015, pages: S76), Publisher: Acta Neurobiologiae Experimentalis 75 (3)
    Date:
    conference 6-8 September
    Status:
    Published

  13. Spinalization and locomotor training affect muscarininc acetylcholine receptor type 2 differently in motoneurons innervating antagonistically acting Soleus and Tibialis ant. muscles.

    Authors:
    Angelika Więckowska, Olga Gajewska-Woźniak, Julita Czarkowska-Bauch, Małgorzata Skup
    Conference:
    FENS FORUM (year: 2016, pages: 1), Publisher: Federation of European Neuroscience Societies
    Date:
    conference 2-6 lipca
    Status:
    Published

  14. Reduction in cholinergic and glutamatergic innervation of ankle extensor butnotflexormotoneuronsafterspinalizationcallsforselectivetherapies

    Authors:
    OlgaGajewska-Woźniak and Julita Czarkowska-Bauch
    Conference:
    13 International Congress of the Polish Neuroscience Society (year: 2017, pages: XXIII), Publisher: Acta Neurobiologiae Experimentalis Vol. 77 No. S1
    Date:
    conference 28-31 August
    Status:
    Published
    DOI:
    link to the publication

  15. Spinal cord transection and stimulation of low-threshold proprioceptive fibers in the tibial nerve change expression of AMPA, NMDA and M2 receptors in GL and TA motoneurons

    Authors:
    Benjun Ji, Kamil Grycz, Anna Głowacka, Angelika Więckowska, Olga Gajewska-Woźniak, Julita Czarkowska-Bauch, Małgorzata Skup
    Conference:
    FENS FORUM (year: 2018, pages: -), Publisher: Federation of European Neuroscience Societies
    Date:
    conference 7-11 lipca
    Status:
    Published

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