Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Protein tyrosine phosphatases inhibition as a strategy against infectious diseases and bioterrorism

2012/07/N/NZ1/00012

Keywords:

protein tyrosine phosphatases bioterrorism infectious diseases

Descriptors:

  • NZ1_4: Structural biology
  • NZ1_10: Microbiology
  • NZ1_1: Molecular biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Lekarski

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Alicja Kuban-Jankowska 

Number of co-investigators in the project: 3

Call: PRELUDIUM 4 - announced on 2012-09-15

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2013-08-08

Project end date (Y-m-d): 2016-12-07

Project duration:: 40 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. sprzęt komputerowy (6 090 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Book publications / chapters in book publications (1)
  1. Protein tyrosine phosphatases in pathological process
    Authors:
    Alicja Kuban-Jankowska, Magdalena Gorska, Narcyz Knap, Francesco Cappello, Michal Wozniak
    Academic press:
    Frontiers in Bioscience Landmark Edition (rok: 2015, tom: 20, strony: 377-388), Wydawca: Frontiers in Bioscience
    Status:
    Published
    DOI:
    10.2741/4314 - link to the publication
  2. Redox process is crucial for inhibitory properties of aurintricarboxylic acid against activity of YopH: virulence factor of Yersinia pestis
    Authors:
    Alicja Kuban-Jankowska, Kamlesh K Sahu, Pawel Niedzialkowski, Magdalena Gorska, Jack A Tuszynski, Tadeusz Ossowski, Michal Wozniak
    Academic press:
    Oncotarget (rok: 2015, tom: 45464, strony: 18364-18373), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.4625 - link to the publication
  3. Chicoric acid binds to two sites and decreases the activity of the YopH bacterial virulence factor.
    Authors:
    Kuban-Jankowska A, Sahu KK, Gorska M, Tuszynski JA, Wozniak M.
    Academic press:
    Oncotarget (rok: 2016, tom: 7(3), strony: 2229-38), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.6812 - link to the publication
  4. Inactivation of Protein Tyrosine Phosphatases by Peracids Correlates with the Hydrocarbon Chain Length
    Authors:
    Alicja Kuban-Jankowska, Magdalena Gorska, Jack A. Tuszynski, Cassandra D. M. Churchill, Philip Winter, Mariusz Klobukowski, Michal Wozniak
    Academic press:
    Cellular Physiology and Biochemistry (rok: 2015, tom: 36, strony: 1069-108), Wydawca: Karger
    Status:
    Published
    DOI:
    10.1159/000430280 - link to the publication
  5. The physiological concentration of ferrous iron (II) alters the inhibitory effect of hydrogen peroxide on CD45, LAR and PTP1B phosphatases
    Authors:
    Alicja Kuban-Jankowska . Magdalena Gorska . Lukasz Jaremko . Mariusz Jaremko . Jack A. Tuszynski . Michal Wozniak
    Academic press:
    BioMetals (rok: 2015, tom: 28, strony: 975–986), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10534-015-9882-4 - link to the publication
  6. Aurintricarboxylic acid structure modifications lead to reduction of inhibitory properties against virulence factor YopH and higher cytotoxicity.
    Authors:
    Kuban-Jankowska A, Sahu KK, Gorska M, Niedzialkowski P, Tuszynski JA, Ossowski T, Wozniak M.
    Academic press:
    World Journal of Microbiology and Biotechnology (rok: 2016, tom: 32(10), strony: 163), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11274-016-2123-3 - link to the publication
  1. BIAŁKOWE FOSFATAZY TYROZYNOWE I ICH UDZIAŁ W INFEKCJACH BAKTERYJNYCH
    Authors:
    Alicja Kuban-Jankowska
    Book:
    Na pograniczu chemii i biologii (rok: 2014, tom: 32, strony: 225-240), Wydawca: Wydawnictwo Naukowe UAM
    Status:
    Published

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