Projects funded by the NCN

The influence of environment on biomolecular function, structure and interactions.

Call: SONATA BIS 10 , Panel: ST4

Principal investigator: dr hab. Piotr Mikołaj Setny

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

New 5-HT6 receptor ligands from the group of sulfonamide derivatives of cyclic arylguanidines in the treatment of gliobl...

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: dr Przemysław Patryk Zaręba

Politechnika Krakowska im. Tadeusza Kościuszki, Wydział Inżynierii i Technologii Chemicznej

Increasing the precision of chimeric antigen receptor (CAR)-mediated anticancer immunotherapy by using the chemokine-ind...

Call: OPUS 19 , Panel: NZ6

Principal investigator: dr hab. Radosław Zagożdżon

Warszawski Uniwersytet Medyczny

Molecular mechanism underlying the anti-inflammatory action of CB2 receptor agonists in microglia: participation of the ...

Call: OPUS 19 , Panel: NZ7

Principal investigator: dr Natalia Eleonora Małek-Chudzik

Politechnika Wrocławska

FAST interactions in cell death regulation

Call: PRELUDIUM 19 , Panel: NZ1

Principal investigator: Daria Martyna Dawidziak

Uniwersytet Warszawski, Wydział Chemii

Making use of siderophore transport systems to deliver peptide nucleic acids to bacterial cells

Call: OPUS 19 , Panel: NZ1

Principal investigator: prof. Joanna Dominika Trylska

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

VPS10P domain receptors in phenotypic polarization of astrocytes and microglia in the diseased brain.

Call: OPUS 19 , Panel: NZ3

Principal investigator: dr Anna Róża Malik

Uniwersytet Warszawski

New mechanisms regulating acetylcholine receptors at the neuromuscular junction

Call: OPUS 19 , Panel: NZ3

Principal investigator: dr hab. Tomasz Jacek Prószyński

Sieć Badawcza ŁUKASIEWICZ - PORT Polski Ośrodek Rozwoju Technologii

Determination of the mechanisms responsible for the mobility of non-integrin laminin receptor (LamR) isoforms, including...

Call: PRELUDIUM 19 , Panel: NZ1

Principal investigator: Ewa Mazurkiewicz

Uniwersytet Wrocławski, Wydział Biotechnologii

Investigation into the mechanism of regulation of nicotinic acetylcholine receptors

Call: POLS , Panel: NZ3

Principal investigator: dr Ákos Nemecz

Uniwersytet Mikołaja Kopernika, Wydział Nauk Biologicznych i Weterynaryjnych

Determination of the mechanisms responsible for the impact of non-integrin laminin receptor (LamR) on the development of...

Call: PRELUDIUM 19 , Panel: NZ3

Principal investigator: Ewa Justyna Mrówczyńska

Uniwersytet Wrocławski, Wydział Biotechnologii

Thermodynamics of the interaction of betacoronaviruses with human cel receptor.

Call: OPUS 19 , Panel: NZ6

Principal investigator: dr hab. Danuta Witkowska

Uniwersytet Opolski

Structure-function relationship in fibroblast growth factor signaling

Call: CEUS-UNISONO , Panel: NZ3

Principal investigator: dr hab. Małgorzata Urszula Zakrzewska

Uniwersytet Wrocławski, Wydział Biotechnologii

Recognition of expression and function of new neuropeptide - phoenixin-14 in porcine corpus luteum.

Call: PRELUDIUM 19 , Panel: NZ9

Principal investigator: Ewa Maria Mlyczyńska

Uniwersytet Jagielloński, Wydział Biologii

Towards innovative strategy for treatment of Alzheimer's Disease via dual inhibition of receptor 5-HT6 and kinase CDK5.

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: Sylwia Sudoł-Tałaj

Uniwersytet Jagielloński, Collegium Medicum

Combined administration of muscarinic receptor antagonists and group II/III metabotropic glutamate (mGlu) receptor ligan...

Call: OPUS 19 , Panel: NZ7

Principal investigator: prof. Andrzej Mikołaj Pilc

Instytut Farmakologii PAN

Antisense oligonucleotides and their nanostructures conjugated with boron clusters; physico-chemical and biological char...

Call: ETIUDA 8 , Panel: ST4

Principal investigator: Damian Mateusz Kaniowski

Centrum Badań Molekularnych i Makromolekularnych PAN

Dual histamine H3 and sigma-1 receptor ligands as novel pharmacological tools in the treatment of central nervous system...

Call: SONATINA 4 , Panel: NZ7

Principal investigator: Katarzyna Anna Szczepańska

Instytut Farmakologii PAN

Investigation of novel functionally selective opioid receptors agonists

Call: ETIUDA 8 , Panel: NZ7

Principal investigator: Łucja Elżbieta Szumiec

Instytut Farmakologii PAN

Role of the Intersubunit and Interdomain Interactions in the GABAA Receptor Modulation by Protons.

Call: ETIUDA 8 , Panel: NZ1

Principal investigator: Michał Adam Michałowski

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

Chasing the HARE: elucidation of the binding mechanism of the new and unexplored ligandsof the Hyaluronic Acid Receptor ...

Call: SONATINA 4 , Panel: NZ1

Principal investigator: dr Aleksandra Anna Twarda-Cłapa

Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

Impact of aldosterone excess on structural and functional alternations in heart andkidneys–baseline characteristics and ...

Call: OPUS 18 , Panel: NZ5

Principal investigator: dr hab. Mateusz Śpiewak

Instytut Kardiologii im. Prymasa Tysiąclecia Stefana Kardynała Wyszyńskiego

Novel role of peroxisome proliferator-activated receptor α in the regulationof amyloid β peptide metabolism and mitochon...

Call: PRELUDIUM 18 , Panel: NZ4

Principal investigator: dr Sylwia Żulińska

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Investigation of molecular mechanisms of rapid antidepressant action of NLX-101, a biased agonist of the 5-HT1A receptor...

Call: OPUS 18 , Panel: NZ7

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii PAN

Seeking for CB1 and CB2 receptor ligands among drugs, drug metabolites, and phytochemical compounds

Call: PRELUDIUM 18 , Panel: NZ7

Principal investigator: Adam Stasiulewicz

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

In vivo effects, underlying signaling pathways and mechanism of action of ghrelin receptor agonist against pathological ...

Call: SONATA 15 , Panel: NZ7

Principal investigator: dr Piotr Chmielarz

Instytut Farmakologii PAN

Investigation on PD-L1 biology for precise shaping of anticancer adoptive therapies

Call: SONATA 15 , Panel: NZ6

Principal investigator: dr Agnieszka Graczyk-Jarzynka

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Molecular mechanisms of interplay between RORγ/RORγT receptors and cyclin-dependent kinase inhibitor (AT7519). Analysis ...

Call: PRELUDIUM 18 , Panel: NZ7

Principal investigator: Kaja Urszula Karaś

Instytut Biologii Medycznej PAN

Comprehensive study of the role of Rysto, a TIR-NB-LRR class receptor in potato innate immunity

Call: SONATA 15 , Panel: NZ9

Principal investigator: dr Marta Karolina Grech-Baran

Instytut Biochemii i Biofizyki PAN

SARMs as a modulators of metabolic functions and oxidative stress in adipose and heart tissues in rat obesity model- in ...

Call: PRELUDIUM 18 , Panel: NZ7

Principal investigator: dr Natalia Leciejewska

Uniwersytet Przyrodniczy w Poznaniu, Wydział Medycyny Weterynaryjnej i Nauk o Zwierzętach

Kappa opioid receptors integrate neuronal signaling involved in social behavior

Call: OPUS 18 , Panel: NZ7

Principal investigator: dr hab. Jan Manuel Rodriguez Parkitna

Instytut Farmakologii PAN

Pharmacological modulation of histamine H3 and H4 receptors - a new perspective in the treatment of neuropathic pain

Call: SONATA 15 , Panel: NZ7

Principal investigator: dr Katarzyna Popiołek-Barczyk

Instytut Farmakologii PAN

The role of kappa opioid receptors during chronic intestinal inflammation and colitis-associated colorectal cancer – foc...

Call: SONATA 15 , Panel: NZ7

Principal investigator: dr Marta Zielińska

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

The place does matter - 5-HT7R-mediated structural plasticity in the specific hippocampal subregions

Call: SONATA 15 , Panel: NZ4

Principal investigator: dr Monika Bijata

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Peroxisome proliferator-activated receptors beta/delta in the regulation of inflammatory processes in the porcine corpus...

Call: PRELUDIUM 18 , Panel: NZ9

Principal investigator: dr Karol Mierzejewski

Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Biologii i Biotechnologii

Extracellular galectins as controllers of fibroblast growth factor receptor signaling

Call: SONATA BIS 9 , Panel: NZ3

Principal investigator: dr Łukasz Opaliński

Uniwersytet Wrocławski, Wydział Biotechnologii

The role of the oxidative stress in adoptive cell therapy with chimeric antigen receptors

Call: OPUS 17 , Panel: NZ6

Principal investigator: dr Małgorzata Agnieszka Bajor

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Liposomal berberine and anti-CD47 antibody as an effective therapy for the treatment of colorectal cancer

Call: PRELUDIUM 17 , Panel: NZ5

Principal investigator: dr Martyna Maria Mianowska

Uniwersytet Wrocławski, Wydział Biotechnologii

Co-crystallization and co-amorphization of angiotensin II receptor blockers leading to more soluble compounds with a bif...

Call: PRELUDIUM 17 , Panel: ST5

Principal investigator: dr Marika Ewa Turek

Akademia im. Jana Długosza w Częstochowie

Studies of the molecular mechanisms associated with HPV and CMV infections involved in the pathogenesis of ovarian cance...

Call: OPUS 17 , Panel: NZ7

Principal investigator: dr hab. Edyta Teresa Paradowska

Instytut Biologii Medycznej PAN

The assessment of cysteinyl leukotriene receptor antagonist role in inhibition of atherosclerosis, proliferation and its...

Call: OPUS 17 , Panel: NZ5

Principal investigator: dr hab. Paweł Maga

Uniwersytet Jagielloński, Collegium Medicum

Searching for the background underlying the neuroprotective effects of the specific agonist of Y2 receptors - NPY(13-36)...

Call: PRELUDIUM 17 , Panel: NZ4

Principal investigator: Łukasz Przykaza

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Specific interactions of new antitumor unsymmetrical bisacridines, UAs, with DNA and ABC proteins and their potential to...

Call: OPUS 17 , Panel: NZ7

Principal investigator: prof. Zofia Mazerska

Politechnika Gdańska

The EBI2 receptor/oxysterol signalling in multiple sclerosis pathophysiology, therapy and diagnostics.

Call: OPUS 17 , Panel: NZ4

Principal investigator: dr Aleksandra Rutkowska

Gdański Uniwersytet Medyczny, Wydział Lekarski

Neuroprotective properties of 5-HT6 receptor ligands in the group of 2-arylpyrrole derivatives – a new insight into neur...

Call: PRELUDIUM 17 , Panel: NZ7

Principal investigator: Marcin Józef Drop

Uniwersytet Jagielloński, Collegium Medicum

Therapeutic potential of biased 5-HT7 receptor ligands in the treatment of depression

Call: OPUS 17 , Panel: NZ7

Principal investigator: prof. Paweł Maria Zajdel

Uniwersytet Jagielloński, Collegium Medicum

Effects of a novel nonaddictive opioid on response to stress

Call: PRELUDIUM 17 , Panel: NZ7

Principal investigator: dr Łucja Elżbieta Szumiec

Instytut Farmakologii PAN

The role of nitric oxide-dependent pathways in the procognitive effects of muscarinic and metabotropic glutamate recepto...

Call: OPUS 17 , Panel: NZ7

Principal investigator: dr hab. Joanna Monika Wierońska

Instytut Farmakologii PAN

Application of machine learning based artificial intelligence to search for substances that modulate the activity of ROR...

Call: OPUS 17 , Panel: NZ7

Principal investigator: dr hab. Marcin Marek Ratajewski

Instytut Biologii Medycznej PAN

Porównanie właściwości funkcjonalnych podtypów a1-g2 i a1-b2-g2 receptora GABA(A) w kontekście interakcji międzypodjedno...

Call: ETIUDA 7 , Panel: NZ3

Principal investigator: dr Marek Maciej Brodzki

Uniwersytet Wrocławski, Wydział Nauk Biologicznych