Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Studies of the molecular mechanisms associated with HPV and CMV infections involved in the pathogenesis of ovarian cancer

2019/33/B/NZ7/02872

Keywords:

epithelial ovarian cancer human papilloma virus cytomegalovirus genotype oncogene Toll-like receptor genetic polymorphisms cytokines

Descriptors:

  • NZ6_5: Virology
  • NZ7_1: Epidemiology
  • NZ5_1: Etiology of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Biologii Medycznej Polskiej Akademii Nauk

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Edyta Teresa Paradowska 

Number of co-investigators in the project: 9

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 2 090 684 PLN

Project start date (Y-m-d): 2020-10-01

Project end date (Y-m-d): 2025-06-30

Project duration:: 57 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (24)
  1. The Toll-like Receptor 4 Polymorphism Asp299Gly Is Associated with an Increased Risk of Ovarian Cancer
    Authors:
    Katarzyna D Kania, Daria Haręża, Jacek R Wilczyński, Miłosz Wilczyński, Dariusz Jarych, Andrzej Malinowski, Edyta Paradowska
    Academic press:
    Cells (rok: 2022, tom: 11, strony: 3137), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11193137 - link to the publication
  2. Prediction of Chemoresistance—How Preclinical Data Could Help to Modify Therapeutic Strategy in High-Grade Serous Ovarian Cancer
    Authors:
    Wilczyński J., Paradowska E., Wilczyńska J., Wilczyński M.
    Academic press:
    Current Oncology (rok: 2024, tom: 31, strony: 229–249), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/curroncol31010015 - link to the publication
  3. Cancer Stem Cells in Ovarian Cancer—A Source of Tumor Success and a Challenging Target for Novel Therapies
    Authors:
    Jacek R Wilczyński, Miłosz Wilczyński, Edyta Paradowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 2496), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23052496 - link to the publication
  4. Endometriosis Stem Cells as a Possible Main Target for Carcinogenesis of Endometriosis-Associated Ovarian Cancer (EAOC)
    Authors:
    Jacek R Wilczyński, Maria Szubert, Edyta Paradowska, Miłosz Wilczyński
    Academic press:
    Cancers (rok: 2022, tom: 15, strony: 111), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers15010111 - link to the publication
  5. Prediction of Chemoresistance—How Preclinical Data Could Help to Modify Therapeutic Strategy in High-Grade Serous Ovarian Cancer
    Authors:
    Wilczyński J., Paradowska E., Wilczyńska J., Wilczyński M.
    Academic press:
    Current Oncology (rok: 2024, tom: 31, strony: 229–249), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/curroncol31010015 - link to the publication
  6. Cancer Stem Cells in Ovarian Cancer—A Source of Tumor Success and a Challenging Target for Novel Therapies
    Authors:
    Jacek R Wilczyński, Miłosz Wilczyński, Edyta Paradowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 2496), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23052496 - link to the publication
  7. Personalization of Therapy in High-Grade Serous Tubo-Ovarian Cancer—The Possibility or the Necessity?
    Authors:
    Wilczyński J., Paradowska E., Wilczyński M.
    Academic press:
    Journal of Personalized Medicine (rok: 2024, tom: 14(1), strony: 49), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jpm14010049 - link to the publication
  8. Endometriosis Stem Cells as a Possible Main Target for Carcinogenesis of Endometriosis-Associated Ovarian Cancer (EAOC)
    Authors:
    Jacek R Wilczyński, Maria Szubert, Edyta Paradowska, Miłosz Wilczyński
    Academic press:
    Cancers (rok: 2022, tom: 15, strony: 111), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers15010111 - link to the publication
  9. "DEPHENCE" system-a novel regimen of therapy that is urgently needed in the high-grade serous ovarian cancer-a focus on anti-cancer stem cell and anti-tumor microenvironment targeted therapies
    Authors:
    Wilczyński J.R., Wilczyński M., Paradowska E.
    Academic press:
    Frontiers in Oncology (rok: 2023, tom: 13, strony: 1201497), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fonc.2023.1201497 - link to the publication
  10. Personalization of Therapy in High-Grade Serous Tubo-Ovarian Cancer—The Possibility or the Necessity?
    Authors:
    Wilczyński J., Paradowska E., Wilczyński M.
    Academic press:
    Journal of Personalized Medicine (rok: 2024, tom: 14(1), strony: 49), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jpm14010049 - link to the publication
  11. Cancer Stem Cells in Ovarian Cancer—A Source of Tumor Success and a Challenging Target for Novel Therapies
    Authors:
    Jacek R Wilczyński, Miłosz Wilczyński, Edyta Paradowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 2496), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23052496 - link to the publication
  12. Human Papillomaviruses as Infectious Agents in Gynecological Cancers―Oncogenic Properties of Viral Proteins
    Authors:
    Daria A. Haręża, Jacek R. Wilczyński, Edyta Paradowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 1818), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23031818 - link to the publication
  13. Human Papillomaviruses as Infectious Agents in Gynecological Cancers―Oncogenic Properties of Viral Proteins
    Authors:
    Daria A. Haręża, Jacek R. Wilczyński, Edyta Paradowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 1818), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23031818 - link to the publication
  14. High-Grade Serous Ovarian Cancer-A Risk Factor Puzzle and Screening Fugitive
    Authors:
    Jacek Wilczyński, Edyta Paradowska, Miłosz Wilczyński
    Academic press:
    Biomedicines (rok: 2024, tom: 12, strony: 229), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines12010229 - link to the publication
  15. Differential microRA Expression Analysis in Patients with HPV-Infected Ovarian Neoplasms
    Authors:
    Jarych D., Mikulski D., Wilczyński M., Wilczyński J.R., Kania K.D., Haręża D., Malinowski A., Perdas E., Nowak M., Paradowska E.
    Academic press:
    International Journal of Molecular Sciences (rok: 2024, tom: 25, strony: 762), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms25020762 - link to the publication
  16. Differential microRA Expression Analysis in Patients with HPV-Infected Ovarian Neoplasms
    Authors:
    Jarych D., Mikulski D., Wilczyński M., Wilczyński J.R., Kania K.D., Haręża D., Malinowski A., Perdas E., Nowak M., Paradowska E.
    Academic press:
    International Journal of Molecular Sciences (rok: 2024, tom: 25, strony: 762), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms25020762 - link to the publication
  17. "DEPHENCE" system-a novel regimen of therapy that is urgently needed in the high-grade serous ovarian cancer-a focus on anti-cancer stem cell and anti-tumor microenvironment targeted therapies
    Authors:
    Wilczyński J.R., Wilczyński M., Paradowska E.
    Academic press:
    Frontiers in Oncology (rok: 2023, tom: 13, strony: 1201497), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fonc.2023.1201497 - link to the publication
  18. Cancer Stem Cells in Ovarian Cancer—A Source of Tumor Success and a Challenging Target for Novel Therapies
    Authors:
    Jacek R Wilczyński, Miłosz Wilczyński, Edyta Paradowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 2496), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23052496 - link to the publication
  19. Endometriosis Stem Cells as a Possible Main Target for Carcinogenesis of Endometriosis-Associated Ovarian Cancer (EAOC)
    Authors:
    Jacek R Wilczyński, Maria Szubert, Edyta Paradowska, Miłosz Wilczyński
    Academic press:
    Cancers (rok: 2022, tom: 15, strony: 111), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers15010111 - link to the publication
  20. Human Papillomaviruses as Infectious Agents in Gynecological Cancers―Oncogenic Properties of Viral Proteins
    Authors:
    Daria A. Haręża, Jacek R. Wilczyński, Edyta Paradowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 1818), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23031818 - link to the publication
  21. Human papillomavirus infection of the fallopian tube as a potential risk factor for epithelial ovarian cancer
    Authors:
    Edyta Paradowska, Daria A Haręża, Katarzyna D Kania, Dariusz Jarych, Miłosz Wilczyński, Andrzej Malinowski, Monika Kawecka, Mateusz Nowak, Jacek R Wilczyński
    Academic press:
    Scientific Reports (rok: 2024, tom: 14, strony: 21602), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-024-72814-0 - link to the publication
  22. The Toll-like Receptor 4 Polymorphism Asp299Gly Is Associated with an Increased Risk of Ovarian Cancer
    Authors:
    Katarzyna D Kania, Daria Haręża, Jacek R Wilczyński, Miłosz Wilczyński, Dariusz Jarych, Andrzej Malinowski, Edyta Paradowska
    Academic press:
    Cells (rok: 2022, tom: 11, strony: 3137), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11193137 - link to the publication
  23. Human Papillomaviruses as Infectious Agents in Gynecological Cancers―Oncogenic Properties of Viral Proteins
    Authors:
    Daria A. Haręża, Jacek R. Wilczyński, Edyta Paradowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 1818), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23031818 - link to the publication
  24. The Toll-like Receptor 4 Polymorphism Asp299Gly Is Associated with an Increased Risk of Ovarian Cancer
    Authors:
    Katarzyna D Kania, Daria Haręża, Jacek R Wilczyński, Miłosz Wilczyński, Dariusz Jarych, Andrzej Malinowski, Edyta Paradowska
    Academic press:
    Cells (rok: 2022, tom: 11, strony: 3137), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11193137 - link to the publication

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