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Specific interactions of new antitumor unsymmetrical bisacridines, UAs, with DNA and ABC proteins and their potential to modulate the enzymatic activity and transcription of nuclear receptors as the elements of their molecular mechanism of action.

2019/33/B/NZ7/02534

Keywords:

antitumor bisacridines UAs drug-DNA interactions ABC proteins transcriptional effect of drugs antitumor drug metabolism nuclear receptors urine and blood metabolites.

Descriptors:

  • NZ1_2: Biochemistry
  • NZ3_1: Cell biology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Politechnika Gdańska

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Zofia Mazerska 

Number of co-investigators in the project: 10

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 3 011 720 PLN

Project start date (Y-m-d): 2020-04-02

Project end date (Y-m-d): 2023-09-01

Project duration:: 41 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (10)
  • Articles in post-conference publications (16)
  1. Acid-base equilibrium and self association in relation to high antitumor activity of selected unsymmetrical bisacridines established by extensive chemometric analysis
    Authors:
    Michał Kosno, Tomasz Laskowski, Joanna E. Frackowiak, Agnieszka Potęga, Agnieszka Kurdyn, Witold Andrałojć, Julia Borzyszkowska-Bukowska, Katarzyna Szwarc-Karabyka, Zofia Mazerska
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: 3995 + 14), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27133995 - link to the publication
  2. The interactions of monomeric acridines and unsymmetrical bisacridines (UAs) with DNA duplexes: an insight provides by NMR and MD studies.
    Authors:
    Tomasz Laskowski, Michał kosno, Witold Andrałojć, Joanna E. Frackowiak, Julia Borzyszkowska-Bukowska, Paweł Szczeblewski, Nikola Radoń, Maria Świerżewska, Anna Woźny, Ewa Paluszkiewicz, Zofia Mazerska
    Academic press:
    Scientific reports (rok: 2023, tom: 13, strony: 3431), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-023-30587-y - link to the publication
  3. Metabolic profiles of new unsymmetrical bisacridine antitumor agents in electrochemical and enzymatic noncellular systems and in tumor cells.
    Authors:
    Anna Mieszkowska, Anna M. Nowicka, Agata Kowalczyk, Agnieszka Potega, Monika Pawłowska, Michał Kosno, Ewa Augustin and Zofia Mazerska
    Academic press:
    Pharmaceuticals (rok: 2021, tom: 14, strony: 317 (28 stron)), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ph14040317 - link to the publication
  4. Metabolic profiles of new unsymmetrical bisacridine antitumor agents in electrochemical and enzymatic noncellular systems and in tumor cells.
    Authors:
    Anna Mieszkowska, Anna M. Nowicka, Agata Kowalczyk, Agnieszka Potega, Monika Pawłowska, Michał Kosno, Ewa Augustin and Zofia Mazerska
    Academic press:
    Pharmaceuticals (rok: 2021, tom: 14, strony: 317 (28 stron)), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ph14040317 - link to the publication
  5. The interactions of Pu22 G-quadruplex, derived from c-Myc protooncogene promoter sequence, with antitumor acridine derivatives - an NMR/MD combined study
    Authors:
    M.Kosno, W.Andrałojć, R.Stojałowski, J. Borzyszkowska-Bukowska, E.Paluszkiewicz, Z.Mazerska, T.Laskowski
    Academic press:
    Journal of Medicinal Chemistry, submitted ID jm-2023-01987d (rok: 2023, tom: brak, strony: brak), Wydawca: ACS, Manuscript ID jm-2023-01987d
    Status:
    Submitted
  6. The interactions of monomeric acridines and unsymmetrical bisacridines (UAs) with DNA duplexes: an insight provides by NMR and MD studies.
    Authors:
    Tomasz Laskowski, Michał kosno, Witold Andrałojć, Joanna E. Frackowiak, Julia Borzyszkowska-Bukowska, Paweł Szczeblewski, Nikola Radoń, Maria Świerżewska, Anna Woźny, Ewa Paluszkiewicz, Zofia Mazerska
    Academic press:
    Scientific reports (rok: 2023, tom: 13, strony: 3431), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-023-30587-y - link to the publication
  7. Metabolic profiles of new unsymmetrical bisacridine antitumor agents in electrochemical and enzymatic noncellular systems and in tumor cells.
    Authors:
    Anna Mieszkowska, Anna M. Nowicka, Agata Kowalczyk, Agnieszka Potega, Monika Pawłowska, Michał Kosno, Ewa Augustin and Zofia Mazerska
    Academic press:
    Pharmaceuticals (rok: 2021, tom: 14, strony: 317 (28 stron)), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ph14040317 - link to the publication
  8. Acid-base equilibrium and self association in relation to high antitumor activity of selected unsymmetrical bisacridines established by extensive chemometric analysis
    Authors:
    Michał Kosno, Tomasz Laskowski, Joanna E. Frackowiak, Agnieszka Potęga, Agnieszka Kurdyn, Witold Andrałojć, Julia Borzyszkowska-Bukowska, Katarzyna Szwarc-Karabyka, Zofia Mazerska
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: 3995 + 14), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27133995 - link to the publication
  9. c-Myc protein level affected by unsymmetrical bisacridines influences apoptosis and senescence induced in HCT116 colorectal and H460 lung cancer cells.
    Authors:
    Monika Pawłowska, Jolanta Kulesza, Ewa Augustin
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 3061 + 23), Wydawca: Licensee MDPI, Basel, Switzeland
    Status:
    Published
    DOI:
    10.3390/ijms23063061 - link to the publication
  10. c-Myc protein level affected by unsymmetrical bisacridines influences apoptosis and senescence induced in HCT116 colorectal and H460 lung cancer cells.
    Authors:
    Monika Pawłowska, Jolanta Kulesza, Ewa Augustin
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 3061 + 23), Wydawca: Licensee MDPI, Basel, Switzeland
    Status:
    Published
    DOI:
    10.3390/ijms23063061 - link to the publication
  1. 3D spheroid culture system of HCT116 colon and A549 lung cancer cells in the study of the cellular response induced by antitumor unsymmetrical bisacridines in these cells.
    Authors:
    Jolanta Kulesza, Monika Pawłowska, Ewa Augustin
    Conference:
    FEBS Open BIO, Volum.12, Issue SI, Suplement:The Biochemistry Global Summit, Lisbon, July 2022 (rok: 2022, tom: 25th IUBMB Congres, 46th FEBS Congress, !5th PABMB Congress, 9-14 July 2022, Lisbon, Portugal, strony: 88), Wydawca: FEBS
    Data:
    konferencja 9-14th July 2022
    Status:
    Published
    DOI:
    xxxxxxxx - link to the publication
  2. Delivery and release of the anticancer compound C-2045 in LS174T colon cancer cells and identification of its metabolites.
    Authors:
    Joanna E Frackowiak, Michał Kosno, Paweł Kubica, Ewa Paluszkiewicz, Ewa Augustin, Zofia Mazerska
    Conference:
    Inflammation links Cancer & Neurodegeneration, ECDO2022, September 26th-29th, 2022, CDD Press, DZNE Bonn, Germany (rok: 2022, tom: European Cell Death Organisation, ECDO 2022, September 26th-29th 2022, strony: 65), Wydawca: CDD Press, DZNE Bonn, Germany
    Data:
    konferencja September 26th-29th 2022
    Status:
    Published
    DOI:
    xxxxxxxxxxx - link to the publication
  3. Unsymmetrical bisacridines target parallel G-quadruplexes, yet not double-stranded DNA
    Authors:
    Tomasz Laskowski, Michał Kosno, Zofia Mazerska
    Conference:
    X Konwersatorium Chemii Medycznej (rok: 2021, tom: X Konwersatorium Chemii Medycz, strony: 93), Wydawca: Polskie Towarzystwo Chemii Medycznej
    Data:
    konferencja 3-5. 09. 2021
    Status:
    Published
  4. Unique physicochemical properties of the unsymmetrical bisacridines and their importance
    Authors:
    Michał Kosno, Tomasz Laskowski, Joanna Frąckowiak, Zofia Mazerska
    Conference:
    X Konwersatorium Chemii Medycznej (rok: 2021, tom: X Konwersatorium Chemii Medycz, strony: 36), Wydawca: Polskie Towarzystwo Chemii Medycznej
    Data:
    konferencja 3-5. 09. 2021
    Status:
    Published
    DOI:
    brak - link to the publication
  5. Preliminary studies on the interactions between antitumor unsymmetrical bisacridines, UAs, and DNA using monomer acridine derivatives as model compounds.
    Authors:
    Michał Kosno, Tomasz Laskowski, Zofia Mazerska
    Conference:
    FEBS Open BIO, Volum.12, Issue SI, Suplement:The Biochemistry Global Summit, Lisbon, July 2022 (rok: 2022, tom: 25th IUBMB Congres, 46th FEBS Congress, !5th PABMB Congress, 9-14 July 2022, Lisbon, Portugal, strony: 273), Wydawca: FEBS
    Data:
    konferencja 9-14th July 2022
    Status:
    Published
    DOI:
    xxxxxxxxxxx - link to the publication
  6. Unsymmetrical bisacridines target parallel G-quadruplexes, yet not double-stranded DNA
    Authors:
    Tomasz Laskowski, Michał Kosno, Zofia Mazerska
    Conference:
    X Konwersatorium Chemii Medycznej (rok: 2021, tom: X Konwersatorium Chemii Medycz, strony: 93), Wydawca: Polskie Towarzystwo Chemii Medycznej
    Data:
    konferencja 3-5. 09. 2021
    Status:
    Published
  7. 3D spheroid culture system of HCT116 colon and A549 lung cancer cells in the study of the cellular response induced by antitumor unsymmetrical bisacridines in these cells.
    Authors:
    Jolanta Kulesza, Monika Pawłowska, Ewa Augustin
    Conference:
    FEBS Open BIO, Volum.12, Issue SI, Suplement:The Biochemistry Global Summit, Lisbon, July 2022 (rok: 2022, tom: 25th IUBMB Congres, 46th FEBS Congress, !5th PABMB Congress, 9-14 July 2022, Lisbon, Portugal, strony: 88), Wydawca: FEBS
    Data:
    konferencja 9-14th July 2022
    Status:
    Published
    DOI:
    xxxxxxxx - link to the publication
  8. Unsymmetrical bisacridines target parallel G-quadruplexes, yet not double-stranded DNA
    Authors:
    Tomasz Laskowski, Michał Kosno, Zofia Mazerska
    Conference:
    X Konwersatorium Chemii Medycznej (rok: 2021, tom: X Konwersatorium Chemii Medycz, strony: 93), Wydawca: Polskie Towarzystwo Chemii Medycznej
    Data:
    konferencja 3-5. 09. 2021
    Status:
    Published
    DOI:
    brak - link to the publication
  9. Unsymmetrical bisacridine derivatives show anticancer potential by inducing apoptosis in human prostate, colon and pancreatic cancer cells
    Authors:
    Agnieszka Kurdyn, Jolanta Kulesza, Monika Pawłowska, Ewa Paluszkiewicz, Ewa Augustin.
    Conference:
    Inflammation links Cancer & Neurodegeneration, ECDO2022, September 26th-29th, 2022, CDD Press, DZNE Bonn, Germany (rok: 2022, tom: European Cell Death Organisation, ECDO 2022, September 26th-29th 2022, strony: 76), Wydawca: CDD Press, DZNE Bonn, Germany
    Data:
    konferencja September 26th-29th 2022
    Status:
    Published
    DOI:
    xxxxxxxxxxx - link to the publication
  10. Unique physicochemical properties of the unsymmetrical bisacridines and their importance
    Authors:
    Michał Kosno, Tomasz Laskowski, Joanna Frąckowiak, Zofia Mazerska
    Conference:
    X Konwersatorium Chemii Medycznej (rok: 2021, tom: X Konwersatorium Chemii Medycz, strony: 36), Wydawca: Polskie Towarzystwo Chemii Medycznej
    Data:
    konferencja 3-5. 09. 2021
    Status:
    Published
  11. Unsymmetrical bisacridine derivatives show anticancer potential by inducing apoptosis in human prostate, colon and pancreatic cancer cells
    Authors:
    Agnieszka Kurdyn, Jolanta Kulesza, Monika Pawłowska, Ewa Paluszkiewicz, Ewa Augustin.
    Conference:
    Inflammation links Cancer & Neurodegeneration, ECDO2022, September 26th-29th, 2022, CDD Press, DZNE Bonn, Germany (rok: 2022, tom: European Cell Death Organisation, ECDO 2022, September 26th-29th 2022, strony: 76), Wydawca: CDD Press, DZNE Bonn, Germany
    Data:
    konferencja September 26th-29th 2022
    Status:
    Published
    DOI:
    xxxxxxxxxxx - link to the publication
  12. Preliminary studies on the interactions between antitumor unsymmetrical bisacridines, UAs, and DNA using monomer acridine derivatives as model compounds.
    Authors:
    Michał Kosno, Tomasz Laskowski, Zofia Mazerska
    Conference:
    FEBS Open BIO, Volum.12, Issue SI, Suplement:The Biochemistry Global Summit, Lisbon, July 2022 (rok: 2022, tom: 25th IUBMB Congres, 46th FEBS Congress, !5th PABMB Congress, 9-14 July 2022, Lisbon, Portugal, strony: 273), Wydawca: FEBS
    Data:
    konferencja 9-14th July 2022
    Status:
    Published
    DOI:
    xxxxxxxxxxx - link to the publication
  13. Interactions of antitumor unsymmetrical bisacridines with ABC transporters:MDR1, MRP1 and MRP2.
    Authors:
    Monika Pawłowska, Joanna Frąckowiak, Jolanta Kulesza, Ewa Augustin, Zofia Mazerska
    Conference:
    FEBS Open BIO, Volum.12, Issue SI, Suplement:The Biochemistry Global Summit, Lisbon, July 2022, (rok: 2022, tom: 25th IUBMB Congres, 46th FEBS Congress, !5th PABMB Congress, 9-14 July 2022, Lisbon, Portugal, strony: 111), Wydawca: FEBS
    Data:
    konferencja 9-14th July 2022
    Status:
    Published
    DOI:
    xxxxxx - link to the publication
  14. Unique physicochemical properties of the unsymmetrical bisacridines and their importance
    Authors:
    Michał Kosno, Tomasz Laskowski, Joanna Frąckowiak, Zofia Mazerska
    Conference:
    X Konwersatorium Chemii Medycznej (rok: 2021, tom: X Konwersatorium Chemii Medycz, strony: 36), Wydawca: Polskie Towarzystwo Chemii Medycznej
    Data:
    konferencja 3-5. 09. 2021
    Status:
    Published
  15. Delivery and release of the anticancer compound C-2045 in LS174T colon cancer cells and identification of its metabolites.
    Authors:
    Joanna E Frackowiak, Michał Kosno, Paweł Kubica, Ewa Paluszkiewicz, Ewa Augustin, Zofia Mazerska
    Conference:
    Inflammation links Cancer & Neurodegeneration, ECDO2022, September 26th-29th, 2022, CDD Press, DZNE Bonn, Germany (rok: 2022, tom: European Cell Death Organisation, ECDO 2022, September 26th-29th 2022, strony: 65), Wydawca: CDD Press, DZNE Bonn, Germany
    Data:
    konferencja September 26th-29th 2022
    Status:
    Published
    DOI:
    xxxxxxxxxxx - link to the publication
  16. Interactions of antitumor unsymmetrical bisacridines with ABC transporters:MDR1, MRP1 and MRP2.
    Authors:
    Monika Pawłowska, Joanna Frąckowiak, Jolanta Kulesza, Ewa Augustin, Zofia Mazerska
    Conference:
    FEBS Open BIO, Volum.12, Issue SI, Suplement:The Biochemistry Global Summit, Lisbon, July 2022, (rok: 2022, tom: 25th IUBMB Congres, 46th FEBS Congress, !5th PABMB Congress, 9-14 July 2022, Lisbon, Portugal, strony: 111), Wydawca: FEBS
    Data:
    konferencja 9-14th July 2022
    Status:
    Published
    DOI:
    xxxxxx - link to the publication

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