Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Antisense oligonucleotides and their nanostructures conjugated with boron clusters; physico-chemical and biological characterization - attempts to estimate the potential of compounds for the use in BNCT therapy.

2020/36/T/ST4/00485

Keywords:

Therapeutic antisense oligonucleotides (ASOs) Boron-neutron capture therapy (BNCT) Epidermal growth factor receptor (EGFR)

Descriptors:

  • ST4_9: Biological chemistry
  • ST4_8: Organic chemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

Damian Mateusz Kaniowski 

Number of co-investigators in the project: 1

Call: ETIUDA 8 - announced on 2019-12-16

Amount awarded: 138 168 PLN

Project start date (Y-m-d): 2020-10-01

Project end date (Y-m-d): 2022-11-23

Project duration:: 26 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Molecular Mechanisms of Specific Cellular DNA Damage Response and Repair Induced by the Mixed Radiation Field During Boron Neutron Capture Therapy
    Authors:
    Maliszewska-Olejniczak K, Kaniowski D, Araszkiewicz M, Tymińska K, Korgul A.
    Academic press:
    Frontiers in Oncology (rok: 2021, tom: 11, strony: 676575), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fonc.2021.676575 - link to the publication
  2. Boron Clusters as Enhancers of RNase H Activity in the Smart Strategy of Gene Silencing by Antisense Oligonucleotides
    Authors:
    Kaniowski, D.; Kulik, K.; Suwara, J.; Ebenryter-Olbińska, K.; Nawrot, B.
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 12190), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms232012190 - link to the publication
  3. EGFR-Targeted Cellular Delivery of Therapeutic Nucleic Acids Mediated by Boron Clusters
    Authors:
    Kaniowski, D.; Suwara, J.; Ebenryter-Olbińska, K.; Jakóbik-Kolon, A.; Nawrot, B.
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 14793), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms232314793 - link to the publication
  4. Composites of Nucleic Acids and Boron Clusters (C2B10H12) as Functional Nanoparticles for Downregulation of EGFR Oncogene in Cancer Cells
    Authors:
    Kaniowski D, Ebenryter-Olbińska K, Kulik K, Suwara J, Cypryk W, Jakóbik-Kolon A, Leśnikowski Z, Nawrot B.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 4863), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094863 - link to the publication

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