Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Investigation of molecular mechanisms of rapid antidepressant action of NLX-101, a biased agonist of the 5-HT1A receptors, in animal models of depression and treatment-resistant depression

2019/35/B/NZ7/00787

Keywords:

5-HT1A receptors biased agonist ketamina chronic mild stress model of depression anhedonia and cognitive deficits prefrontal cortex neuronal plasticity markers AMPA receptors AKT ERK and mTOR pathways 5-HT1A autoradiography Wistar and Wistar-Kyoto rats.

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Mariusz Papp 

Number of co-investigators in the project: 6

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 1 075 590 PLN

Project start date (Y-m-d): 2020-07-29

Project end date (Y-m-d): 2024-07-28

Project duration:: 48 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (9)
  1. The 5-HT1A receptor biased agonists, NLX-204 and NLX-101, display ketamine-like RAAD and anti-TRD activities in rat CMS models
    Authors:
    Papp M, Gruca P, Lason M, Litwa E, Newman-Tancredi A, Depoortère R
    Academic press:
    Psychopharmacology (rok: 2023, tom: 1, strony: 1), Wydawca: Springer
    Status:
    Submitted
  2. Models of Affective Illness: Chronic Mild Stress in the Rat.
    Authors:
    Papp M, Willner P.
    Academic press:
    Current Protocols (rok: 2023, tom: 3, strony: 45670), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/cpz1.712. - link to the publication
  3. The 5-HT1A receptor biased agonists, NLX-204 and NLX-101, display ketamine-like RAAD and anti-TRD activities in rat CMS models
    Authors:
    Papp M, Gruca P, Lason M, Litwa E, Newman-Tancredi A, Depoortère R
    Academic press:
    Psychopharmacology (rok: 2023, tom: 240, strony: 2419-2433), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00213-023-06389-5 - link to the publication
  1. Ketamine and the 5-HT1A receptor biased agonists, NLX-204 and NLX-101, share common cortical efficacious rapid acting antidepressant mechanisms in rat cms depression model.
    Authors:
    Gruca P, Litwa E, Lason M, Newman-Tancredi A, DepoortŁre R, PAPP M.
    Conference:
    Eur. Neuropsychopharmacol. (rok: 2023, tom: 36th ECNP Congress, Barcelona, strony: P.1090), Wydawca: Elsevier
    Data:
    konferencja 7-10 październik, 2023
    Status:
    Published
  2. The 5-HT1A receptor biased agonists, NLX-101 and NLX-204, elicit rapid-acting antidepressant activity in rat similar to ketamine and via GABAergic mechanisms.
    Authors:
    Newman-Tancredi A, Depoortère R, Gruca P, Litwa E, Lason M, PAPP M.
    Conference:
    International Journal of Psychological and Behavioral Sciences, Vol:16, No:10 (rok: 2022, tom: International Conference on Behavioral Neuroscience and Psychopharmacology (ICBNP), Dubrovnik, Chorwacja, strony: 1), Wydawca: Scientific & Academic Publishing
    Data:
    konferencja 6-7.10.2022
    Status:
    Published
  3. Selective cortical 5-HT1A receptor biased agonists, NLX-101 and NLX-204, has rapid-acting antidepressant effects in the rat chronic mild stress model of depression and TRD
    Authors:
    M. Papp, P. Gruca, R. Depoortère and A. Newman-Tancredi.
    Conference:
    Abstract Book (rok: 2021, tom: Neurons in Action, strony: 6), Wydawca: Instytut Biologii Doświadczalnej im. M. Nenckiego PAN
    Data:
    konferencja 29 Listopad - 1 grudzień, 2021
    Status:
    Published
    DOI:
    brak - link to the publication
  4. Similarly to ketamine, selective cortical 5-HT1A receptor biased agonists elicit rapid-acting antidepressant effects in the rat chronic mild stress model
    Authors:
    M. Papp, P. Gruca, E. Litwa, M. Lason, R. Depoortère and A. Newman-Tancredi
    Conference:
    European Neuropsychopharmacology (rok: 2021, tom: 34th ECNP Congress, Lizbona, strony: S443-S444), Wydawca: Elsevier
    Data:
    konferencja 2-5 października, 2021
    Status:
    Published
    DOI:
    10.569 - link to the publication
  5. The 5-HT1A receptor biased agonists, NLX-101 and NLX-204, elicit rapid-acting antidepressant activity in rat similar to ketamine and via GABAergic mechanisms.
    Authors:
    Newman-Tancredi A, Depoortère R, Gruca P, Litwa E, Lason M, PAPP M.
    Conference:
    International Journal of Psychological and Behavioral Sciences, Vol:16, No:10 (rok: 2022, tom: International Conference on Behavioral Neuroscience and Psychopharmacology (ICBNP), Dubrovnik, Chorwacja, strony: 1), Wydawca: Scientific & Academic Publishing
    Data:
    konferencja 6-7.10.2022
    Status:
    Published
  6. Similarly to ketamine, selective cortical 5-HT1A receptor biased agonists elicit rapid-acting antidepressant effects in the rat chronic mild stress model
    Authors:
    M. Papp, P. Gruca, E. Litwa, M. Lason, R. Depoortère and A. Newman-Tancredi
    Conference:
    European Neuropsychopharmacology (rok: 2021, tom: 34th ECNP Congress, Lizbona, strony: S443-S444), Wydawca: Elsevier
    Data:
    konferencja 2-5 października, 2021
    Status:
    Published
    DOI:
    10.569 - link to the publication
  7. Selective cortical 5-HT1A receptor biased agonists, NLX-101 and NLX-204, has rapid-acting antidepressant effects in the rat chronic mild stress model of depression and TRD
    Authors:
    M. Papp, P. Gruca, R. Depoortère and A. Newman-Tancredi.
    Conference:
    Abstract Book (rok: 2021, tom: Neurons in Action, strony: 6), Wydawca: Instytut Biologii Doświadczalnej im. M. Nenckiego PAN
    Data:
    konferencja 29 Listopad - 1 grudzień, 2021
    Status:
    Published
    DOI:
    brak - link to the publication
  8. Selective cortical 5-HT1A receptor biased agonists, NLX-101 and NLX-204, has rapid-acting antidepressant effects in the rat chronic mild stress model of depression and TRD
    Authors:
    M. Papp, P. Gruca, R. Depoortère and A. Newman-Tancredi.
    Conference:
    Abstract Book (rok: 2021, tom: Neurons in Action, strony: 6), Wydawca: Instytut Biologii Doświadczalnej im. M. Nenckiego PAN
    Data:
    konferencja 29 Listopad - 1 grudzień, 2021
    Status:
    Published
    DOI:
    brak - link to the publication
  9. Similarly to ketamine, selective cortical 5-HT1A receptor biased agonists elicit rapid-acting antidepressant effects in the rat chronic mild stress model
    Authors:
    M. Papp, P. Gruca, E. Litwa, M. Lason, R. Depoortère and A. Newman-Tancredi
    Conference:
    European Neuropsychopharmacology (rok: 2021, tom: 34th ECNP Congress, Lizbona, strony: S443-S444), Wydawca: Elsevier
    Data:
    konferencja 2-5 października, 2021
    Status:
    Published
    DOI:
    10.569 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy