Projects funded by the NCN
Investigation of molecular mechanisms of rapid antidepressant action of NLX-101, a biased agonist of the 5-HT1A receptors, in animal models of depression and treatment-resistant depression
2019/35/B/NZ7/00787
Keywords:
5-HT1A receptors biased agonist ketamina chronic mild stress model of depression anhedonia and cognitive deficits prefrontal cortex neuronal plasticity markers AMPA receptors AKT ERK and mTOR pathways 5-HT1A autoradiography Wistar and Wistar-Kyoto rats.
Descriptors:
- NZ7_14: Pharmacy, pharmacotherapy, pharmacology
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk
woj. małopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 6
Call: OPUS 18 - announced on 2019-09-16
Amount awarded: 1 075 590 PLN
Project start date (Y-m-d): 2020-07-29
Project end date (Y-m-d): 2023-07-28
Project duration:: 36 months (the same as in the proposal)
Project status: Project completed
Project description
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