Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Effects of a novel nonaddictive opioid on response to stress

2019/33/N/NZ7/02378

Keywords:

PZM21 biased opioids μ opioid receptor stress genes expression animal models

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ5_7: Human disease treatment

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Łucja Elżbieta Szumiec 

Number of co-investigators in the project: 3

Call: PRELUDIUM 17 - announced on 2019-03-15

Amount awarded: 185 451 PLN

Project start date (Y-m-d): 2020-02-06

Project end date (Y-m-d): 2024-02-05

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (5)
  1. The differential influence of PZM21, a nonrewarding μ-opioid receptor agonist with G protein bias, on behavioural despair and fear response in mice
    Authors:
    Lucja Szumiec, Ryszard Bugno, Lukasz Szumiec, Ryszard Przewlocki
    Academic press:
    Behavioural Brain Research (rok: 2023, tom: 449, strony: 114466), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbr.2023.114466 - link to the publication
  1. The effects of a G protein-biased opioid, PZM21, and morphine on conditioned fear response in mice
    Authors:
    Lucja Kudla, Ryszard Bugno, Andrzej J. Bojarski, Ryszard Przewlocki
    Conference:
    Neuroscience Applied, Volume 1, Supplement 2 (rok: 2022, tom: 35th ECNP Congress, strony: 451), Wydawca: Elsevier
    Data:
    konferencja 15-18 października 2022
    Status:
    Published
    DOI:
    10.1016/j.nsa.2022.101009 - link to the publication
  2. Influence of a G protein-biased mu-opioid receptor agonist, PZM21, on behavioural response to stress and anxiogenic conditions
    Authors:
    Lucja Kudla, Ryszard Bugno, Andrzej Bojarski, Ryszard Przewlocki
    Conference:
    European Neuropsychopharmacology Volume 53, Supplement 1 (rok: 2021, tom: 34th ECNP Congress, strony: S667-S668), Wydawca: Elsevier
    Data:
    konferencja 2-5 października 2021
    Status:
    Published
    DOI:
    10.764 - link to the publication
  3. The effects of a G protein-biased opioid, PZM21, and morphine on conditioned fear response in mice
    Authors:
    Lucja Kudla, Ryszard Bugno, Andrzej J. Bojarski, Ryszard Przewlocki
    Conference:
    Neuroscience Applied, Volume 1, Supplement 2 (rok: 2022, tom: 35th ECNP Congress, strony: 451), Wydawca: Elsevier
    Data:
    konferencja 15-18 października 2022
    Status:
    Published
    DOI:
    10.1016/j.nsa.2022.101009 - link to the publication
  4. Influence of a G protein-biased mu-opioid receptor agonist, PZM21, on behavioural response to stress and anxiogenic conditions
    Authors:
    Lucja Kudla, Ryszard Bugno, Andrzej Bojarski, Ryszard Przewlocki
    Conference:
    European Neuropsychopharmacology Volume 53, Supplement 1 (rok: 2021, tom: 34th ECNP Congress, strony: S667-S668), Wydawca: Elsevier
    Data:
    konferencja 2-5 października 2021
    Status:
    Published
    DOI:
    10.764 - link to the publication
  5. Influence of a G protein-biased mu-opioid receptor agonist, PZM21, on behavioural response to stress and anxiogenic conditions
    Authors:
    Lucja Kudla, Ryszard Bugno, Andrzej Bojarski, Ryszard Przewlocki
    Conference:
    European Neuropsychopharmacology Volume 53, Supplement 1 (rok: 2021, tom: 34th ECNP Congress, strony: S667-S668), Wydawca: Elsevier
    Data:
    konferencja 2-5 października 2021
    Status:
    Published
    DOI:
    10.764 - link to the publication

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